RGD Reference Report - Cytokine polymorphisms predict the frequency of otitis media as a complication of rhinovirus and RSV infections in children. - Rat Genome Database

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Cytokine polymorphisms predict the frequency of otitis media as a complication of rhinovirus and RSV infections in children.

Authors: Alper, CM  Winther, B  Hendley, JO  Doyle, WJ 
Citation: Alper CM, etal., Eur Arch Otorhinolaryngol. 2009 Feb;266(2):199-205. doi: 10.1007/s00405-008-0729-2. Epub 2008 Jun 17.
RGD ID: 7365038
Pubmed: PMID:18560870   (View Abstract at PubMed)
PMCID: PMC7087847   (View Article at PubMed Central)
DOI: DOI:10.1007/s00405-008-0729-2   (Journal Full-text)

Previous studies suggested that the otitis media (OM) complication rate of viral upper respiratory infection (vURI) is conditioned by genes affecting cytokine production. Two hundred and thirty children (114 male; 187 White, 25 Black; aged 1-9.3 years, average=3.6+/-1.6 years) were prospectively followed over the typical cold season for cold-like illness and OM. Nasopharyngeal secretion samples collected during cold-like illness and OM were assayed for upper respiratory viruses and buccal samples were assayed for TNFalpha (-308), IL-10(-1082, -819, -592), IL-6 (-174) and IFN-gamma (+874) polymorphisms. Logistic regression was used to identify genotypes that predict OM coincident with RSV and rhinovirus (RV) infection. Of the 157 children with RV detection (79 male; 132 White, 13 Black, 12 Other; aged 3.6+/-1.5 years), simple logistic regression identified age (B= -0.34, Z= -2.8, P<0.01, OR=0.71), IL-6 (B= -0.76, Z= -3.3, P<0.01, OR=0.47) and IL-10 (B=0.49, Z=2.0, P=0.05, OR=1.6) as significant predictors of OM coincidence. A more complex logistic regression model for RV detection that included selected OM risk factors identified these factors as well as the TNFalpha genotype, OM history, breastfeeding history and daily environment as significant predictors of OM coincidence. Of the 43 children with RSV detection (21 male; 35 White, 5 Black, 3 Other, aged 3.9+/-1.7 years), logistic regression identified IL-10 (B=1.05, Z=2.0, P=0.05, OR=2.9) as a significant predictor of OM coincidence. New OM episodes coincident with evidence of RSV and RV infection were significantly more frequent in children with high production IL-10 phenotypes. The low production IL-6 and high production TNFalpha phenotypes also contributed to OM risk during RV detection. Cytokine polymorphisms may be one of an expectedly large number of genetic factors contributing to the known heritability of OM.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
otitis media  IAGP 7365038associated with respiratory syncytial virus infectious disease more ...RGD 
otitis media  ISOIL10 (Homo sapiens)7365038; 7365038associated with respiratory syncytial virus infectious disease more ...RGD 

Phenotype Annotations    Click to see Annotation Detail View

Manual Human Phenotype Annotations - RGD

TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
Abnormal middle ear morphology  IAGP 7365038associated with respiratory syncytial virus infectious disease more ...RGD 
Otitis media  IAGP 7365038associated with respiratory syncytial virus infectious disease more ...RGD 
Objects Annotated

Genes (Rattus norvegicus)
Il10  (interleukin 10)

Genes (Mus musculus)
Il10  (interleukin 10)

Genes (Homo sapiens)
IL10  (interleukin 10)


Additional Information