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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2886 Species: Rattus norvegicus RGD Object: Gene Symbol: Il10 Name: interleukin 10

Acc ID: CHEBI:4495 Term: diazoxide Definition: A benzothiadiazine that is the S,S-dioxide of 2H-1,2,4-benzothiadiazine which is substituted at position 3 by a methyl group and at position 7 by chlorine. A peripheral vasodilator, it increases the concentration of glucose in the plasma and inhibits the secretion of insulin by the beta- cells of the pancreas. It is used orally in the management of intractable hypoglycaemia and intravenously in the management of hypertensive emergencies. CasRN: 7683-59-2 Chemical ID: MESH:D003981

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
decreases secretion	ISO	RGD:735591	6480464	CTD	Diazoxide results in decreased secretion of IL10 protein	PMID:16612254
multiple interactions	ISO	RGD:10785	6480464	CTD	Isoproterenol promotes the reaction [Lipopolysaccharides results in increased expression of IL10 protein]	PMID:9038718