RGD Reference Report - Factors associated with inflammatory cytokine patterns in community-acquired pneumonia. - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models   new Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources

Factors associated with inflammatory cytokine patterns in community-acquired pneumonia.

Authors: Martinez, R  Menendez, R  Reyes, S  Polverino, E  Cilloniz, C  Martinez, A  Esquinas, C  Filella, X  Ramirez, P  Torres, A 
Citation: Martinez R, etal., Eur Respir J. 2010 Jul 1.
RGD ID: 4140400
Pubmed: PMID:20595152   (View Abstract at PubMed)
DOI: DOI:10.1183/09031936.00040710   (Journal Full-text)

Raised systemic levels of interleukin-6 and interleukin-10 cytokine have been associated with poorer outcome in community-acquired pneumonia. The aim of our study was to identify potential associated factors with increased levels of interleukin-6, interleukin-10, or both cytokine. We performed a prospective study of 685 patients admitted to hospital with community-acquired pneumonia. Interleukin-6 and interleukin-10 were measured in blood in the first 24 hours. Thirty-day mortality increased from 4.8% to 11.4% (p: 0.003) when both cytokines were higher than the median. Independent associated factors with an excess of interleukin-6 were neurologic disease, confusion, serum sodium <130 mEq.L(-1), pleural effusion, and bacteremia. The associated factors for an excess of interleukin-10 were respiratory rate >/=30 rpm, systolic blood pressure <90 mm Hg and glycemia >/=250 mg.dL(-1). The independent associated factors for an excess of both cytokines were confusion, systolic blood pressure <90 mmHg, pleural effusion, and bacteremia. Protective factors were prior antibiotic treatment and pneumococcal vaccination. Different independent factors are related to an excess of interleukin-6 and interleukin-10. Confusion, hypotension, pleural effusion, and bacteremia are associated with the inflammatory profile with the highest mortality rate, whereas antipneumococcal vaccination and previous antibiotic treatment appear as protective factors.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
pneumonia disease_progressionIEP 4140400; 4140400protein:increased expression:bloodRGD 
pneumonia disease_progressionISOIL10 (Homo sapiens)4140400; 4140400protein:increased expression:bloodRGD 
pneumonia disease_progressionISOIL6 (Homo sapiens)4140400; 4140400protein:increased expression:bloodRGD 

Objects Annotated

Genes (Rattus norvegicus)
Il10  (interleukin 10)
Il6  (interleukin 6)

Genes (Mus musculus)
Il10  (interleukin 10)
Il6  (interleukin 6)

Genes (Homo sapiens)
IL10  (interleukin 10)
IL6  (interleukin 6)


Additional Information