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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2886
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Il10
Name: interleukin 10
Acc ID: CHEBI:35456
Term: cadmium dichloride
Definition: A cadmium coordination entity in which cadmium(2+) and Cl(-) ions are present in the ratio 2:1. Although considered to be ionic, it has considerable covalent character to its bonding.
Chemical ID: MESH:D019256
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Il10increases expressionEXP 6480464CTDCadmium Chloride results in increased expression of IL10 proteinPMID:24954678
Il10multiple interactionsEXP 6480464CTD[Cadmium Chloride results in increased abundance of Cadmium] which results in decreased expression of IL10 protein; Silymarin inhibits the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in decreased expression of IL10 protein]; Sodium Selenite inhibits the reaction [Cadmium Chloride results in increased expression of IL10 protein]PMID:24954678 PMID:36718047
Il10decreases expressionISOIl10 (Mus musculus)6480464CTDCadmium Chloride results in decreased expression of IL10 proteinPMID:23038000
Il10increases expressionISOIL10 (Homo sapiens)6480464CTDCadmium Chloride results in increased expression of IL10 proteinPMID:26138014
Il10multiple interactionsISOIl10 (Mus musculus)6480464CTD[Cadmium Chloride results in increased abundance of Cadmium] which results in decreased expression of IL10 mRNA; [Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of IL10 mRNA; butane-2,3-dione thiosemicarbazone oxime inhibits the reaction [Cadmium Chloride results in decreased expression of IL10 protein]PMID:23038000 PMID:32917723 PMID:33359024
Il10multiple interactionsISOIL10 (Homo sapiens)6480464CTD[Cadmium Chloride results in increased abundance of Cadmium] which results in decreased expression of IL10 mRNA; Acetylcysteine inhibits the reaction [Cadmium Chloride results in increased expression of IL10 protein]; MitoTEMPO inhibits the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in decreased expression of IL10 mRNA]; PPARG protein inhibits the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in decreased expression of IL10 mRNA]PMID:26138014 PMID:32917723 PMID:35301059
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