RGD Reference Report - Effects of indomethacin-loaded nanocapsules in experimental models of inflammation in rats. - Rat Genome Database

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Effects of indomethacin-loaded nanocapsules in experimental models of inflammation in rats.

Authors: Bernardi, A  Zilberstein, AC  Jager, E  Campos, MM  Morrone, FB  Calixto, JB  Pohlmann, AR  Guterres, SS  Battastini, AM 
Citation: Bernardi A, etal., Br J Pharmacol. 2009 May 6.
RGD ID: 2311045
Pubmed: PMID:19422380   (View Abstract at PubMed)
PMCID: PMC2785531   (View Article at PubMed Central)
DOI: DOI:10.1111/j.1476-5381.2009.00244.x   (Journal Full-text)

Background and purpose: The effects of systemic treatment with indomethacin-loaded nanocapsules (IndOH-NC) were compared with those of free indomethacin (IndOH) in rat models of acute and chronic oedema. Experimental approach: The following models of inflammation were employed: carrageenan-induced acute oedema (measured between 30 min and 4 h), sub-chronic oedema induced by complete Freund's adjuvant (CFA) (determined between 2 h and 72 h), and CFA-induced arthritis (oedema measured between 14 and 21 days). Key results: IndOH or IndOH-NC produced equal inhibition of carrageenan-elicited oedema. However, IndOH-NC was more effective in both the sub-chronic (33 +/- 4% inhibition) and the arthritis (35 +/- 2% inhibition) model of oedema evoked by CFA, when compared with IndOH (21 +/- 2% and 14 +/- 3% inhibition respectively) (P < 0.01). In the CFA arthritis model, treatment with IndOH-NC markedly inhibited the serum levels of the pro-inflammatory cytokines tumour necrosis factor alpha and IL-6 (by 83 +/- 8% and 84 +/- 11% respectively), while the levels of the anti-inflammatory cytokine IL-10 were significantly increased (196 +/- 55%). The indices of gastrointestinal damage in IndOH-NC-treated animals were significantly less that those after IndOH treatment (58 +/- 16%, 72 +/- 6% and 69 +/- 2%, for duodenum, jejunum and ileum respectively). Conclusions and implications: IndOH-NC produced an increased anti-inflammatory efficacy in long-term models of inflammation, allied to an improved gastrointestinal safety. This formulation might represent a promising alternative for treating chronic inflammatory diseases, with reduced undesirable effects.

Gene Ontology Annotations    Click to see Annotation Detail View

Biological Process
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
response to xenobiotic stimulus  IEP 2311045indomethacinRGD 

Objects Annotated

Genes (Rattus norvegicus)
Il10  (interleukin 10)


Additional Information