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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2886
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Il10
Name: interleukin 10
Acc ID: CHEBI:53556
Term: toluene 2,4-diisocyanate
Definition: A toluene meta-diisocyanate in which the isocyanato groups are at positions 2 and 4 relative to the methyl group on the benzene ring.
Chemical ID: MESH:D014051
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Il10decreases secretionISOIl10 (Mus musculus)6480464CTDToluene 2,4-Diisocyanate results in decreased secretion of IL10 proteinPMID:33711354
Il10increases expressionISOIl10 (Mus musculus)6480464CTDToluene 2,4-Diisocyanate results in increased expression of IL10 mRNA; Toluene 2,4-Diisocyanate results in increased expression of IL10 proteinPMID:11243917 PMID:12884401 PMID:16940033 PMID:19422874 PMID:19428947
Il10multiple interactionsISOIl10 (Mus musculus)6480464CTD5-(5-(4-fluoro-2-hydroxyphenyl)furan-2-ylmethylene)thiazolidine-2,4-dione inhibits the reaction [Toluene 2,4-Diisocyanate results in decreased secretion of IL10 protein]; 5-quinoxalin-6-ylmethylenethiazolidine-2,4-dione inhibits the reaction [Toluene 2,4-Diisocyanate results in decreased secretion of IL10 protein]; IC 87114 inhibits the reaction [Toluene 2,4-Diisocyanate results in decreased secretion of IL10 protein]; N-(1-(7-fluoro-2-(pyridin-2-yl)quinolin-3-yl)ethyl)-9H-purin-6-amine inhibits the reaction [Toluene 2,4-Diisocyanate results in decreased secretion of IL10 protein]PMID:33711354
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