RGD Reference Report - Effects of Cissampelos sympodialis Eichl. and its Alkaloid, Warifteine, in an Experimental Model of Respiratory Allergy to Blomia tropicalis. - Rat Genome Database

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Effects of Cissampelos sympodialis Eichl. and its Alkaloid, Warifteine, in an Experimental Model of Respiratory Allergy to Blomia tropicalis.

Authors: Cerqueira-Lima, AT  Alcantara-Neves, NM  De Carvalho, LC  Costa, RS  Maria Barbosa-Filho, J  Piuvezam, M  Momtchilo, R  Barboza, R  De Jesus Oliveira, E  Marinho, A  Figueiredo, CA 
Citation: Cerqueira-Lima AT, etal., Curr Drug Targets. 2010 Jun 28.
RGD ID: 4140460
Pubmed: PMID:20583974   (View Abstract at PubMed)

Asthma is one of the most prevalent chronic diseases worldwide. Medicinal plants are historically used in its treatment. The plant Cissampelos sympodialis, known in Northeastern Brazil as "Jarrinha" or "Milona", is used to treat some inflammatory conditions, including asthma. The objective of this study was to evaluate the potential of Cissampelos sympodialis EICHL. extract (CsE) and its isolated alkaloids, especially warifteine (Wa) on a Blomia tropicalis extract (BtE)-induced experimental model of allergy. The respiratory allergy was induced in AJ mice by the administration of BtE. Mice were orally treated with the 400 mg/kg of CsE or 8 mg/kg of total alkaloids fraction (TAF) or 4 mg/kg of Wa and the following parameters were analyzed: (a) total cell numbers in bronchoalveolar fluid (BAF); (b) differential cell numbers in BAF; (c) eosinophil peroxidase (EPO) activity in BAF; (d) IgE serum levels by passive cutaneous anaphylaxis; (e) IL-5, IL-13, IL-10, and IFN-gamma levels in BAF; (f) histopathological alterations in the lung. The treatment of the animals with CsE, Wa or TAF led to a reduction in the numbers of total cells and eosinophils in BAF. The same reduction was observed in EPO levels in the BAF. The levels of IL-5 and IL-13 were also reduced in animals treated with Cissampelos sympodialis, while IL-10 levels were significantly increased in the BAF of CsE-treated animals. The treatment also decreased the density of inflammatory cells in the lung by histopathological examination demonstrating the potential of this medicinal plant as new agent for asthma treatment.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
respiratory allergy  ISOIl10 (Mus musculus)4140460; 4140460 RGD 
respiratory allergy  IDA 4140460 RGD 

Objects Annotated

Genes (Rattus norvegicus)
Il10  (interleukin 10)

Genes (Mus musculus)
Il10  (interleukin 10)

Genes (Homo sapiens)
IL10  (interleukin 10)


Additional Information