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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2886
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Il10
Name: interleukin 10
Acc ID: CHEBI:25434
Term: bis(2-chloroethyl) sulfide
Definition: An ethyl sulfide that is diethyl sulfide in which a hydrogen from each of the terminal methyl groups is replaced by a chlorine. It is a powerful vesicant regulated under the Chemical Weapons Convention.
Chemical ID: MESH:D009151
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Il10decreases expressionISOIl10 (Mus musculus)6480464CTDMustard Gas results in decreased expression of IL10 mRNAPMID:19778212
Il10multiple interactionsISOIL10 (Homo sapiens)6480464CTDIL10 protein affects the reaction [Mustard Gas affects the expression of CD40LG mRNA]; IL10 protein affects the reaction [Mustard Gas affects the expression of ERBB4 mRNA]; IL10 protein affects the reaction [Mustard Gas affects the expression of FAS mRNA]; IL10 protein affects the reaction [Mustard Gas affects the expression of FASLG mRNA]; IL10 protein affects the reaction [Mustard Gas affects the expression of FGF8 mRNA]; IL10 protein affects the reaction [Mustard Gas affects the expression of FGF9 mRNA]; IL10 protein affects the reaction [Mustard Gas affects the expression of IL3 mRNA]; IL10 protein affects the reaction [Mustard Gas affects the expression of KDR mRNA]; IL10 protein affects the reaction [Mustard Gas affects the expression of NOTCH2 mRNA]; IL10 protein affects the reaction [Mustard Gas affects the expression of NTF3 mRNA]; IL10 protein affects the reaction [Mustard Gas affects the expression of PDCD10 mRNA]; IL10 protein affects the reaction [Mustard Gas affects the expression of PDGFA mRNA]; IL10 protein affects the reaction [Mustard Gas affects the expression of PDGFRB mRNA]; IL10 protein affects the reaction [Mustard Gas affects the expression of TNFB mRNA]; IL10 protein affects the reaction [Mustard Gas affects the expression of TNFRSF10A mRNA]; IL10 protein affects the reaction [Mustard Gas affects the expression of VEGFB mRNA]; IL10 protein affects the reaction [Mustard Gas affects the expression of VEGFC mRNA]; IL10 protein inhibits the reaction [Mustard Gas results in increased expression of CXCL8 protein]; IL10 protein inhibits the reaction [Mustard Gas results in increased expression of IL6 protein]PMID:16173061
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