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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2886
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Il10
Name: interleukin 10
Acc ID: CHEBI:18295
Term: histamine
Definition: A member of the class of imidazoles that is 1H-imidazole substituted at position C-4 by a 2-aminoethyl group.
Chemical ID: MESH:D006632
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Il10multiple interactionsISOIL10 (Homo sapiens)6480464CTD[IL12A protein binds to IL12B protein] inhibits the reaction [Histamine inhibits the reaction [IL18 protein results in decreased expression of IL10 protein]]; Famotidine inhibits the reaction [Histamine inhibits the reaction [IL18 protein results in decreased expression of IL10 protein]]; Histamine inhibits the reaction [IL18 protein results in decreased expression of IL10 protein]; HRH2 protein affects the reaction [Histamine inhibits the reaction [IL18 protein results in decreased expression of IL10 protein]]; Ranitidine inhibits the reaction [Histamine inhibits the reaction [IL18 protein results in decreased expression of IL10 protein]]; Terfenadine inhibits the reaction [Histamine results in increased expression of IL10 protein]PMID:11752121 PMID:12925206
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