Ifng (interferon gamma) - Rat Genome Database

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Gene: Ifng (interferon gamma) Rattus norvegicus
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Symbol: Ifng
Name: interferon gamma
RGD ID: 2866
Description: Predicted to enable cytokine activity. Involved in several processes, including microglial cell activation; negative regulation of cell population proliferation; and positive regulation of macromolecule metabolic process. Located in extracellular space and perikaryon. Used to study several diseases, including Chagas disease; allergic conjunctivitis; allergic rhinitis; renal fibrosis; and ureteral obstruction. Biomarker of several diseases, including artery disease (multiple); autoimmune thyroiditis; pulpitis; tongue squamous cell carcinoma; and visual epilepsy. Human ortholog(s) of this gene implicated in several diseases, including ataxia telangiectasia; autoimmune disease (multiple); eczema herpeticum; factor VIII deficiency; and leukemia (multiple). Orthologous to human IFNG (interferon gamma); PARTICIPATES IN interleukin-12 signaling pathway; interleukin-2 signaling pathway; interleukin-23 signaling pathway; INTERACTS WITH (+)-pilocarpine; (2E,4E)-hexa-2,4-dienoic acid; (R,R)-tramadol.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: If2f; IFN-gamma; IFNG2; interferon 2f
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8755,789,180 - 55,793,216 (+)NCBIGRCr8
mRatBN7.2753,903,339 - 53,907,375 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl753,903,337 - 53,907,375 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx755,810,041 - 55,814,077 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0758,013,127 - 58,017,163 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0757,790,977 - 57,795,013 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0761,337,383 - 61,341,419 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl761,337,381 - 61,341,419 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0761,333,604 - 61,337,640 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4757,621,756 - 57,625,792 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1757,642,485 - 57,646,522 (+)NCBI
Celera750,671,237 - 50,675,273 (+)NCBICelera
RH 3.4 Map7479.11RGD
Cytogenetic Map7q22NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
abdominal aortic aneurysm  (IEP)
acquired immunodeficiency syndrome  (ISO)
acute disseminated encephalomyelitis  (ISO)
Acute Lung Injury  (IEP)
acute lymphoblastic leukemia  (ISO)
acute myocardial infarction  (IEP)
acute promyelocytic leukemia  (ISO)
acute retinal necrosis syndrome  (ISO)
adrenoleukodystrophy  (ISO)
adult T-cell leukemia/lymphoma  (ISO)
Alcoholic Intoxication  (ISO)
allergic conjunctivitis  (IDA,ISO)
allergic contact dermatitis  (ISO)
allergic disease  (ISO)
allergic rhinitis  (IDA,ISO)
Animal Disease Models  (ISO)
anterior uveitis  (ISO)
aplastic anemia  (ISO,ISS)
appendicitis  (ISO)
asthma  (ISO)
ataxia telangiectasia  (ISO)
atherosclerosis  (ISO)
atopic dermatitis  (ISO)
autistic disorder  (ISO)
autoimmune disease  (ISO)
autoimmune hepatitis  (ISO)
autoimmune thyroiditis  (IEP)
B-Cell Chronic Lymphocytic Leukemia  (ISO)
bacterial pneumonia  (ISO)
Behcet's disease  (ISO)
brain disease  (ISO)
breast cancer  (ISO)
Breast Neoplasms  (ISO)
Bronchial Hyperreactivity  (IEP)
bronchiolitis obliterans  (ISO)
bronchitis  (ISO)
brucellosis  (ISO)
cardiac arrest  (ISO)
cataract  (ISO)
celiac disease  (ISO)
Chagas disease  (IDA)
Chemical and Drug Induced Liver Injury  (ISO)
Chills  (ISO)
chlamydia  (ISO)
choroiditis  (ISO)
chromoblastomycosis  (ISO)
chronic granulomatous disease  (ISO)
Chronic Hepatitis B  (ISO)
Chronic Pancreatitis  (IEP)
Chronic Thyroiditis  (ISO)
colitis  (ISO)
Colonic Neoplasms  (ISO)
colorectal carcinoma  (ISO)
congestive heart failure  (ISO)
Corneal Perforation  (ISO)
Coronavirus infectious disease  (ISO)
COVID-19  (ISO)
Crohn's disease  (ISO)
cutaneous leishmaniasis  (ISO)
Delayed Hypersensitivity  (ISO)
dermatomyositis  (ISO)
Diabetic Nephropathies  (ISO)
diabetic neuropathy  (ISO)
disease of cellular proliferation  (ISO)
Drug Eruptions  (ISO)
Drug-Related Side Effects and Adverse Reactions  (ISO)
dry eye syndrome  (ISO)
Dyspepsia  (IEP)
eczema herpeticum  (ISO)
endometriosis  (ISO)
endophthalmitis  (IEP)
Endotoxemia  (IEP)
Entamoebiasis  (ISO)
Experimental Arthritis  (IMP,ISO)
Experimental Autoimmune Encephalomyelitis  (ISO)
Experimental Autoimmune Uveoretinitis  (IEP)
Experimental Colitis  (IEP,ISO)
Experimental Diabetes Mellitus  (IEP,ISO)
Experimental Liver Cirrhosis  (ISO)
Experimental Neoplasms  (ISO)
Experimental Radiation Injuries  (ISO)
Experimental Sarcoma  (ISO)
eyelid disease  (ISO)
factor VIII deficiency  (ISO)
Fanconi anemia  (ISO)
Fever  (ISO)
genetic disease  (ISO)
genital herpes  (ISO)
glomerulonephritis  (ISO)
glucosephosphate dehydrogenase deficiency  (ISO)
graft-versus-host disease  (ISO)
Graves ophthalmopathy  (ISO)
Graves' disease  (ISO)
Hantavirus hemorrhagic fever with renal syndrome  (ISO)
Hashimoto Disease  (ISO)
Helicobacter Infections  (ISO)
Hemorrhagic Shock  (IEP)
hepatitis  (ISO)
hepatitis B  (ISO)
hepatitis C  (ISO)
hepatocellular carcinoma  (ISO)
herpes simplex virus keratitis  (ISO)
high grade glioma  (IDA)
human immunodeficiency virus infectious disease  (ISO)
hyper IgE syndrome  (ISO)
hypersensitivity reaction type III disease  (ISO)
Hyponatremia  (ISO)
Hypotension  (ISO)
hypothyroidism  (IEP)
immunodeficiency 69  (ISO)
Inflammation  (ISO)
inflammatory bowel disease  (ISO)
Intestinal Helminthiasis  (ISO)
Kidney Calculi  (ISO)
kidney failure  (ISO)
Kidney Reperfusion Injury  (ISO)
Legionnaires' disease  (ISO)
leishmaniasis  (ISO)
lichen planus  (ISO)
liver cirrhosis  (ISO)
lung disease  (ISO)
Lung Neoplasms  (ISO)
lupus nephritis  (ISO)
lymphoproliferative syndrome  (ISO)
malaria  (ISS)
malignant mesothelioma  (ISO)
Manganese Poisoning  (ISO)
melanoma  (ISO)
Mesothelioma  (ISO)
metabolic dysfunction-associated steatohepatitis  (ISO)
Middle East respiratory syndrome  (ISO)
mixed connective tissue disease  (ISO)
mucocutaneous leishmaniasis  (ISO)
multiple sclerosis  (ISO)
Mycobacterium Infections  (IEP)
Mycoplasma pneumoniae pneumonia  (ISO)
myeloid leukemia  (ISO)
Nasal Polyps  (ISO)
Nausea  (ISO)
Necrosis  (ISO)
nephritis  (ISO)
Nerve Degeneration  (ISO)
neural tube defect  (ISO)
obesity  (IEP)
oral submucous fibrosis  (ISO)
otitis media  (ISO)
Otitis Media with Effusion  (ISO)
pancreatic cancer  (ISO)
panuveitis  (IEP)
peritonitis  (ISO)
pleural disease  (ISO)
pneumonia  (ISO)
polymyositis  (ISO)
primary biliary cholangitis  (ISO)
proteinuria  (ISO)
Pulmonary Arterial Hypertension  (IEP)
pulpitis  (IEP)
relapsing polychondritis  (ISO)
renal fibrosis  (IDA)
Reperfusion Injury  (IEP)
respiratory syncytial virus infectious disease  (ISO)
respiratory system disease  (ISO)
rheumatoid arthritis  (ISO)
Salmonella Infections, Animal  (ISO)
sarcoma  (ISO)
selective IgG deficiency disease  (ISO)
sensorineural hearing loss  (ISO)
Sepsis  (IEP,ISO)
septic arthritis  (ISO)
severe acute respiratory syndrome  (ISO)
Sjogren's syndrome  (ISO)
status asthmaticus  (ISO)
Stevens-Johnson syndrome  (ISO)
Streptococcus pneumonia  (ISO)
Stroke  (ISO)
suppurative otitis media  (ISO)
systemic lupus erythematosus  (ISO)
systemic scleroderma  (ISO)
temporal arteritis  (ISO)
tongue squamous cell carcinoma  (IEP)
toxic shock syndrome  (ISO)
Transplant Rejection  (ISO)
trichuriasis  (ISO)
tuberculosis  (ISO)
tuberous sclerosis  (ISO)
tuberous sclerosis 2  (ISO)
tularemia  (ISO)
type 1 diabetes mellitus  (IMP,ISO,ISS)
type 2 diabetes mellitus  (ISO)
ureteral obstruction  (IDA)
urinary bladder cancer  (ISO)
uveitis  (ISO)
vesicoureteral reflux  (ISO)
viral hepatitis  (ISO)
Viral Myocarditis  (ISO)
visceral leishmaniasis  (ISO)
visual epilepsy  (IEP)
vitiligo  (ISO)
Vogt-Koyanagi-Harada disease  (ISO)
Vomiting  (ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-alpha-viniferin  (ISO)
(+)-pilocarpine  (EXP)
(+)-taxifolin  (ISO)
(+)-Tetrandrine  (ISO)
(+)-trans-(S)-allethrin  (ISO)
(-)-Arctigenin  (ISO)
(-)-citrinin  (ISO)
(-)-demecolcine  (ISO)
(-)-epigallocatechin 3-gallate  (ISO)
(-)-matairesinol  (ISO)
(2E,4E)-hexa-2,4-dienoic acid  (EXP)
(4Z,7Z,10Z,13Z,15E,19Z)-17-hydroxydocosahexaenoic acid  (ISO)
(R,R)-tramadol  (EXP)
(R,R,R)-alpha-tocopherol  (EXP,ISO)
(S)-colchicine  (ISO)
(S)-nicotine  (ISO)
1,1-dichloroethene  (ISO)
1,2-dichloroethane  (EXP)
1,2-dimethylhydrazine  (EXP)
1,3,5-trinitrobenzene  (ISO)
1,3-benzothiazole-2-thiol  (ISO)
1,4-benzoquinone  (ISO)
1,4-phenylenediamine  (ISO)
1-chloro-2,4,6-trinitrobenzene  (ISO)
1-chloro-2,4-dinitrobenzene  (EXP,ISO)
1-fluoro-2,4-dinitrobenzene  (ISO)
1-naphthaleneacetic acid  (ISO)
1-naphthyl isothiocyanate  (EXP,ISO)
15-deoxy-Delta(12,14)-prostaglandin J2  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2,3,3,4,4,5,5,6,6,7,7,8,8,9,9-hexadecafluorononanoic acid  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (ISO)
2,4,6-trinitrobenzenesulfonic acid  (EXP,ISO)
2,4-D  (ISO)
2,4-diaminotoluene  (ISO)
2-(4-chloro-2-methylphenoxy)propanoic acid  (ISO)
2-acetamidofluorene  (EXP)
2-amino-2-deoxy-D-galactopyranose  (EXP,ISO)
2-amino-2-deoxy-D-glucopyranose  (ISO)
2-tert-butylhydroquinone  (ISO)
2-trans,6-trans,10-trans-geranylgeranyl diphosphate  (ISO)
22-Hydroxycholesterol  (ISO)
3',5'-cyclic AMP  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (ISO)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3,3'-diindolylmethane  (ISO)
3,3,4,4,5,5,6,6,7,7,8,8,9,9,10,10,10-heptadecafluoro-1-decanol  (ISO)
3,5-diethoxycarbonyl-1,4-dihydrocollidine  (ISO)
3-acetyldeoxynivalenol  (ISO)
3-chlorophenol  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
3-phenylprop-2-enal  (ISO)
4,4'-diisothiocyano-trans-stilbene-2,2'-disulfonic acid  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-(ethoxymethylene)-2-phenyloxazol-5-one  (ISO)
4-hydroxynon-2-enal  (ISO)
4-methylhistamine  (ISO)
4-nitroaniline  (ISO)
4-nitroquinoline N-oxide  (ISO)
4-nonylphenol  (EXP,ISO)
4-phenylbutyric acid  (ISO)
5'-S-methyl-5'-thioadenosine  (ISO)
5-aza-2'-deoxycytidine  (ISO)
5-azacytidine  (ISO)
5-fluorouracil  (ISO)
5-methoxy-2-\{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl\}-1H-benzimidazole  (ISO)
5-Nitro-2-(3-phenylpropylamino)benzoic acid  (ISO)
6-propyl-2-thiouracil  (EXP)
8-OH-DPAT  (ISO)
9-cis-retinoic acid  (ISO)
abacavir  (ISO)
acetylsalicylic acid  (EXP,ISO)
acrolein  (ISO)
acrylamide  (EXP)
acteoside  (ISO)
actinomycin D  (ISO)
adefovir pivoxil  (ISO)
adenine  (ISO)
adenosine  (ISO)
alclometasone dipropionate  (ISO)
alcohol  (ISO)
aldehydo-D-glucosamine  (ISO)
aldehydo-D-glucose  (EXP,ISO)
all-trans-retinoic acid  (ISO)
all-trans-retinol  (EXP,ISO)
allopurinol  (ISO)
alloxanthine  (ISO)
alpha,alpha-trehalose  (ISO)
alpha-galactosylceramide  (ISO)
alpha-hexylcinnamaldehyde  (ISO)
alpha-linolenic acid  (EXP)
alpha-methylhistamine  (ISO)
alpha-Zearalanol  (ISO)
amiloride  (ISO)
aminoguanidine  (EXP,ISO)
amiodarone  (EXP,ISO)
ammonium chloride  (EXP)
ammonium sulfate  (EXP)
Ammothamnine  (EXP)
amphibole asbestos  (EXP,ISO)
amphotericin B  (ISO)
anandamide  (ISO)
anthra[1,9-cd]pyrazol-6(2H)-one  (EXP,ISO)
anthracen-2-amine  (ISO)
anthranilic acid  (ISO)
antigen  (ISO)
antimony(0)  (ISO)
antirheumatic drug  (ISO)
apigenin  (EXP,ISO)
apocynin  (EXP,ISO)
aripiprazole  (ISO)
aristolochic acid A  (ISO)
arjunolic acid  (EXP)
arsane  (EXP,ISO)
arsenic atom  (EXP,ISO)
arsenite(3-)  (ISO)
arsenous acid  (EXP,ISO)
asbestos  (ISO)
asperentin  (ISO)
astaxanthin  (ISO)
ATP  (ISO)
atrazine  (EXP,ISO)
azathioprine  (ISO)
bafilomycin A1  (ISO)
Bardoxolone methyl  (ISO)
belinostat  (ISO)
benzalkonium chloride  (ISO)
benzamide  (EXP)
Benzamil  (ISO)
benzene  (ISO)
benzene-1,2,4-triol  (ISO)
benzethonium chloride  (ISO)
benzo[a]pyrene  (EXP,ISO)
benzocaine  (ISO)
benzylpenicillin  (ISO)
berberine  (EXP)
Bergenin  (EXP)
beryllium sulfate  (ISO)
beta-amyrin  (ISO)
beta-D-glucan  (ISO)
beta-D-glucosamine  (ISO)
betamethasone valerate  (ISO)
betulin  (ISO)
bezafibrate  (EXP)
biliverdin  (ISO)
bis(2-chloroethyl) sulfide  (EXP)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
Bisphenol A diglycidyl ether  (ISO)
bisphenol F  (ISO)
bleomycin A2  (EXP,ISO)
boric acid  (EXP)
boron atom  (EXP)
bortezomib  (ISO)
bromodichloromethane  (ISO)
bromosulfophthalein  (ISO)
budesonide  (ISO)
butylated hydroxyanisole  (EXP,ISO)
butyric acid  (ISO)
C60 fullerene  (ISO)
cadmium atom  (EXP,ISO)
cadmium dichloride  (EXP,ISO)
Calcimycin  (ISO)
calciol  (ISO)
calcitriol  (ISO)
calcium atom  (ISO)
Calcium propionate  (EXP)
calcium(0)  (ISO)
cannabidiol  (ISO)
Cannabinol  (EXP)
capsaicin  (EXP,ISO)
capsazepine  (ISO)
carbamate ester  (ISO)
carbamazepine  (EXP,ISO)
carbon monoxide  (ISO)
carbon nanotube  (ISO)
carnosic acid  (ISO)
carnosine  (ISO)
Carnosol  (ISO)
carvedilol  (ISO)
caryophyllene oxide  (ISO)
catalpol  (ISO)
catechol  (ISO)
cefoxitin  (ISO)
celastrol  (ISO)
celecoxib  (ISO)
cerium trichloride  (ISO)
chenodeoxycholic acid  (EXP)
chloroethene  (ISO)
chloroform  (ISO)
chloroquine  (ISO)
chlorpromazine  (ISO)
chlorpyrifos  (ISO)
cholesterol  (EXP)
choline  (ISO)
chromium(6+)  (ISO)
chrysin  (ISO)
ciglitazone  (ISO)
cimetidine  (ISO)
ciprofloxacin  (EXP,ISO)
cis-caffeic acid  (EXP,ISO)
cisplatin  (ISO)
citral  (ISO)
clarithromycin  (EXP,ISO)
clobenpropit  (ISO)
clodronic acid  (ISO)
clofibrate  (ISO)
clonidine  (EXP)
clonidine (amino form)  (EXP)
clonidine (imino form)  (EXP)
clozapine  (ISO)
cobalt atom  (ISO)
cobalt dichloride  (EXP,ISO)
cocaine  (ISO)
coformycin  (ISO)
colforsin daropate hydrochloride  (ISO)
coniferyl aldehyde  (ISO)
copper atom  (EXP,ISO)
copper(0)  (EXP,ISO)
copper(II) chloride  (ISO)
cordycepin  (ISO)
cortisol  (ISO)
coumarins  (ISO)
crocidolite asbestos  (ISO)
crotonaldehyde  (EXP,ISO)
curcumin  (EXP,ISO)
cycloastragenol  (EXP)
cycloheximide  (ISO)
cyclophosphamide  (EXP,ISO)
cyclosporin A  (EXP,ISO)
cyfluthrin  (ISO)
cyhalothrin  (EXP)
cypermethrin  (EXP)
cytisine  (ISO)
cytochalasin D  (ISO)
D-glucose  (EXP,ISO)
D-penicillamine  (EXP)
dacarbazine  (ISO)
dantrolene  (ISO)
dapsone  (ISO)
DDE  (ISO)
decabromodiphenyl ether  (ISO)
Decursin  (ISO)
deguelin  (EXP)
delta-tocotrienol  (ISO)
delta8-THC  (ISO)
deoxycholic acid  (EXP)
deoxynivalenol  (ISO)
dexamethasone  (EXP,ISO)
dextran sulfate  (ISO)
diarsenic trioxide  (EXP,ISO)
diazinon  (ISO)
dibenziodolium  (EXP)
Dibenzo[a,i]pyrene  (ISO)
dibenzothiazol-2-yl disulfide  (ISO)
dibutyl phthalate  (EXP,ISO)
dichlorine  (EXP,ISO)
dichloroacetic acid  (ISO)
dichloromethane  (ISO)
dichlorvos  (EXP)
diclofenac  (EXP,ISO)
diethylamine  (ISO)
diethyldithiocarbamic acid  (ISO)
diethylstilbestrol  (ISO)
digoxin  (ISO)
diiodine  (EXP,ISO)
diisononyl phthalate  (ISO)
Dimaprit  (ISO)
dimethyl fumarate  (ISO)
Dimethyl phthalate  (EXP)
dimethyl sulfoxide  (ISO)
dimethyl-(phenylmethyl)-[2-[2-[4-(2,4,4-trimethylpentan-2-yl)phenoxy]ethoxy]ethyl]ammonium  (ISO)
dioxygen  (EXP,ISO)
diquat  (ISO)
disodium selenite  (EXP,ISO)
diuron  (ISO)
dorsomorphin  (ISO)
doxifluridine  (ISO)
doxorubicin  (EXP,ISO)
dydrogesterone  (ISO)
ebselen  (ISO)
edaravone  (EXP)
elemental boron  (EXP)
elemental selenium  (ISO)
ellagic acid  (EXP)
enflurane  (EXP)
enilconazole  (ISO)
entinostat  (ISO)
epinastine  (ISO)
epoxiconazole  (ISO)
eriodictyol  (ISO)
erlotinib hydrochloride  (ISO)
erythromycin A  (ISO)
estriol  (ISO)
ethambutol  (ISO)
ethanol  (EXP,ISO)
ethyl methanesulfonate  (ISO)
ethylisopropylamiloride  (ISO)
eugenol  (ISO)
famotidine  (ISO)
fenbendazole  (ISO)
fenitrothion  (ISO)
fenofibrate  (EXP)
ferroheme b  (ISO)
fluoranthene  (ISO)
fluorescein 5-isothiocyanate  (ISO)
fluoxetine  (ISO)
flurbiprofen  (ISO)
flutamide  (ISO)
fluticasone  (ISO)
folic acid  (EXP)
formaldehyde  (EXP,ISO)
fragrance  (ISO)
fucoidan  (EXP)
fumigaclavine C  (ISO)
fumonisin B1  (ISO)
furfuryl alcohol  (ISO)
gadodiamide hydrate  (ISO)
gadolinium trichloride  (ISO)
gallic acid  (ISO)
gamma-hexachlorocyclohexane  (ISO)
Ganoderic acid C2  (ISO)
Gastrodin  (ISO)
gemcitabine  (ISO)
gemfibrozil  (ISO)
genistein  (EXP,ISO)
gentamycin  (EXP,ISO)
geranial  (ISO)
geraniol  (ISO)
Ginkgolide A  (ISO)
ginsenoside C-K  (ISO)
ginsenoside Re  (ISO)
ginsenoside Rg1  (EXP)
gliotoxin  (ISO)
glucose  (EXP,ISO)
glutathione  (ISO)
glyburide  (ISO)
glycyrrhizinic acid  (ISO)
glyoxal  (EXP)
glyphosate  (ISO)
graphite  (ISO)
GW 1929  (ISO)
GW 7647  (ISO)
halothane  (EXP,ISO)
harmaline  (ISO)
heme b  (ISO)
hemin  (ISO)
herbicide  (ISO)
herbimycin  (EXP,ISO)
heroin  (ISO)
hesperetin  (ISO)
hexachlorobenzene  (EXP,ISO)
hexamethylene diisocyanate  (ISO)
histamine  (ISO)
hyaluronic acid  (EXP)
hydrogen peroxide  (EXP,ISO)
hydroquinone  (ISO)
hypochlorous acid  (ISO)
Ibudilast  (ISO)
ibuprofen  (ISO)
idelalisib  (ISO)
indirubin  (ISO)
indirubin-3'-monoxime  (ISO)
indole-3-acetic acid  (ISO)
indole-3-methanol  (ISO)
indolin-2-one  (ISO)
indometacin  (EXP,ISO)
iobenguane (131I)  (ISO)
ionomycin  (EXP,ISO)
irbesartan  (ISO)
irinotecan  (EXP)
iron atom  (ISO)
iron(0)  (ISO)
isocyanates  (ISO)
isoeugenol  (ISO)
isoliquiritigenin  (ISO)
isoniazide  (ISO)
isopentenyl diphosphate  (ISO)
isoprenaline  (ISO)
jaspamide  (ISO)
kaempferol  (ISO)
kuwanone G  (ISO)
kynurenine  (ISO)
L-ascorbic acid  (EXP,ISO)
L-methionine  (ISO)
L-tryptophan  (ISO)
lactacystin  (ISO)
lamivudine  (ISO)
lansoprazole  (ISO)
latrunculin B  (ISO)
lead diacetate  (ISO)
lead(0)  (ISO)
lead(II) chloride  (ISO)
leflunomide  (ISO)
leukotriene B4  (ISO)
levamisole  (EXP,ISO)
levofloxacin  (EXP)
Licochalcone A  (ISO)
linoleic acid  (ISO)
linuron  (ISO)
lipid As  (ISO)
lipopolysaccharide  (EXP,ISO)
lisuride  (ISO)
lithium carbonate  (ISO)
lithium chloride  (ISO)
LLY-507  (ISO)
losartan  (EXP)
lovastatin  (ISO)
lupane  (ISO)
luteolin  (EXP,ISO)
LY294002  (ISO)
malathion  (EXP,ISO)
malonaldehyde  (ISO)
mancozeb  (ISO)
maneb  (ISO)
manganese atom  (EXP,ISO)
manganese(0)  (EXP,ISO)
manganese(II) chloride  (EXP,ISO)
mangiferin  (EXP,ISO)
manumycin A  (ISO)
MC1568  (ISO)
mecoprop  (ISO)
medroxyprogesterone acetate  (ISO)
melatonin  (EXP,ISO)
mercury atom  (ISO)
mercury dichloride  (EXP,ISO)
mercury(0)  (ISO)
mesalamine  (ISO)
metam  (ISO)
metformin  (ISO)
methamphetamine  (ISO)
methanol  (ISO)
methapyrilene  (EXP)
methcathinone  (ISO)
methimazole  (ISO)
methotrexate  (ISO)
methoxychlor  (ISO)
methyl beta-cyclodextrin  (ISO)
methyl isocyanate  (ISO)
methylcobalamin  (EXP)
methylisothiazolinone  (ISO)
methylmercury chloride  (EXP)
metronidazole  (ISO)
mevalonic acid  (ISO)
mevastatin  (ISO)
microcystin-LR  (EXP,ISO)
mifepristone  (ISO)
minocycline  (ISO)
mithramycin  (ISO)
mitogen  (EXP,ISO)
mocetinostat  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
Monocyte locomotion inhibitory factor  (ISO)
monosodium L-glutamate  (ISO)
morin  (ISO)
morphine  (ISO)
moxifloxacin  (ISO)
muramyl dipeptide  (ISO)
mycophenolic acid  (EXP,ISO)
mycotoxin  (ISO)
N(gamma)-nitro-L-arginine methyl ester  (EXP)
N(omega)-methyl-L-arginine  (ISO)
N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine  (ISO)
N,N-bis(2-hydroxypropyl)nitrosamine  (EXP)
N-[2-[4-(2-methoxyphenyl)-1-piperazinyl]ethyl]-N-(2-pyridinyl)cyclohexanecarboxamide  (ISO)
N-[3-(aminomethyl)benzyl]acetamidine  (ISO)
N-acetyl-beta-D-glucosamine  (ISO)
N-acetyl-D-glucosamine  (ISO)
N-acetyl-L-cysteine  (EXP,ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (EXP,ISO)
N-butyl-N-(4-hydroxybutyl)nitrosamine  (EXP)
N-methyl-4-phenylpyridinium  (ISO)
N-methyl-N-nitrosourea  (EXP,ISO)
N-nitrosodiethylamine  (EXP,ISO)
N-nitrosodimethylamine  (EXP)
N1'-[2-[[5-[(dimethylamino)methyl]-2-furanyl]methylthio]ethyl]-N1-methyl-2-nitroethene-1,1-diamine  (EXP,ISO)
naproxen  (EXP)
naringin  (ISO)
nefazodone  (EXP,ISO)
neocuproine  (ISO)
nevirapine  (EXP,ISO)
nickel atom  (ISO)
nickel dichloride  (ISO)
nickel sulfate  (ISO)
nicotinamide  (ISO)
nicotine  (ISO)
nicotinic acid  (ISO)
nifuroxazide  (ISO)
nimesulide  (EXP,ISO)
nitric oxide  (EXP,ISO)
nitrites  (EXP,ISO)
nitrofurazone  (ISO)
nitrogen dioxide  (ISO)
nitroprusside  (ISO)
nitrososulfamethoxazole  (ISO)
Nivalenol  (ISO)
Nonidet P-40  (ISO)
Nookatone  (EXP)
notoginsenoside R1  (ISO)
NS-398  (EXP,ISO)
ochratoxin A  (ISO)
oleanolic acid  (ISO)
omeprazole  (ISO)
organoselenium compound  (ISO)
oridonin  (EXP,ISO)
oxidopamine  (ISO)
ozone  (EXP,ISO)
paclitaxel  (ISO)
paeoniflorin  (ISO)
palmitoyl ethanolamide  (ISO)
paracetamol  (EXP,ISO)
paraquat  (EXP,ISO)
parathion  (ISO)
patulin  (ISO)
PD 0325901  (ISO)
pendimethalin  (EXP)
pentachlorophenol  (ISO)
pentamidine  (ISO)
perfluorohexanesulfonic acid  (ISO)
perfluorononanoic acid  (EXP,ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (ISO)
permethrin  (EXP,ISO)
phenanthridone  (EXP)
phenethyl caffeate  (ISO)
phenyl benzoate  (ISO)
phenytoin  (ISO)
PhIP  (ISO)
phloretin  (EXP,ISO)
phorbol 13-acetate 12-myristate  (EXP,ISO)
phthalaldehyde  (ISO)
phthalic anhydride  (ISO)
phytoestrogen  (ISO)
pimecrolimus  (ISO)
pioglitazone  (ISO)
piperacillin  (ISO)
piperidine  (ISO)
piperine  (ISO)
piperonyl butoxide  (ISO)
pirinixic acid  (ISO)
platycodin D  (ISO)
plumbagin  (EXP,ISO)
poly(I:C)  (EXP,ISO)
prednisolone  (EXP,ISO)
prednisone  (ISO)
probucol  (ISO)
procymidone  (ISO)
progesterone  (ISO)
propamocarb  (ISO)
propanil  (ISO)
propionic acid  (ISO)
prostaglandin E2  (EXP,ISO)
protein kinase inhibitor  (ISO)
pterostilbene  (ISO)
puerarin  (ISO)
pyrene  (ISO)
pyrrolidine dithiocarbamate  (ISO)
quartz  (ISO)
quercetin  (EXP,ISO)
quercitrin  (EXP)
ranitidine  (EXP,ISO)
Ranitidine bismuth citrate  (ISO)
reactive oxygen species  (EXP,ISO)
resiniferatoxin  (ISO)
resiquimod  (ISO)
resolvin D1  (ISO)
resolvin D2  (ISO)
resveratrol  (EXP,ISO)
Rhein  (ISO)
ribavirin  (ISO)
rifampicin  (ISO)
rifaximin  (ISO)
rimexolone  (ISO)
rimonabant  (EXP)
ritonavir  (ISO)
Ro 41-5253  (ISO)
rotenone  (EXP,ISO)
rottlerin  (ISO)
rutin  (ISO)
ruxolitinib  (ISO)
S-adenosyl-L-methioninate  (ISO)
S-adenosyl-L-methionine  (ISO)
S-nitroso-N-acetyl-D-penicillamine  (ISO)
S-nitrosoglutathione  (ISO)
Salinomycin  (ISO)
Salvianolic acid A  (ISO)
SB 203580  (EXP,ISO)
SB-239063  (ISO)
scopolamine  (EXP)
selenium atom  (ISO)
selenomethionine  (ISO)
serpentine asbestos  (ISO)
sevoflurane  (ISO)
silibinin  (ISO)
silicon dioxide  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
silver(1+) nitrate  (ISO)
silychristin  (ISO)
simazine  (ISO)
simvastatin  (ISO)
Sinomenine  (ISO)
sirolimus  (ISO)
sodium acetate trihydrate  (ISO)
sodium arsenate  (EXP)
sodium arsenite  (EXP,ISO)
sodium aurothiomalate  (ISO)
sodium azide  (ISO)
sodium benzoate  (EXP,ISO)
sodium dichromate  (ISO)
sodium dodecyl sulfate  (ISO)
sodium perchlorate  (EXP)
sodium propionate  (ISO)
Sodium salicylate  (ISO)
sodium stibogluconate  (ISO)
spironolactone  (ISO)
SR 144528  (ISO)
sterigmatocystin  (ISO)
streptozocin  (EXP,ISO)
sulfamethoxazole  (ISO)
sulfapyridine  (ISO)
sulfasalazine  (ISO)
sulforaphane  (EXP,ISO)
sulfoxaflor  (EXP)
sulfur dioxide  (EXP,ISO)
sulindac  (ISO)
sumatriptan  (EXP)
Sunset Yellow FCF  (ISO)
syringin  (ISO)
T-2 toxin  (ISO)
tacrolimus hydrate  (EXP,ISO)
tamibarotene  (EXP,ISO)
tamoxifen  (ISO)
taurine  (EXP)
taurolithocholic acid sulfate  (ISO)
telithromycin  (EXP)
terbutaline  (ISO)
testosterone  (ISO)
tetrachloroethene  (ISO)
tetrachloromethane  (EXP,ISO)
tetracyclines  (ISO)
tetramethylpyrazine  (ISO)
thalidomide  (EXP,ISO)
theophylline  (ISO)
thimerosal  (ISO)
thioacetamide  (EXP)
thiourea  (ISO)
thiram  (ISO)
thymoquinone  (EXP,ISO)
thyroxine  (EXP)
Tiron  (EXP)
titanium atom  (ISO)
titanium dioxide  (ISO)
TMC-120A  (ISO)
tofacitinib  (ISO)
Tolmetin glucuronide  (ISO)
toluene  (ISO)
toluene 2,4-diisocyanate  (ISO)
Trachelogenin  (ISO)
tramadol  (EXP)
trans-caffeic acid  (EXP,ISO)
trans-isoeugenol  (ISO)
trans-piceid  (ISO)
trans-urocanic acid  (ISO)
tributylstannane  (ISO)
Tributyltin oxide  (EXP)
tributyrin  (ISO)
tricaproin  (ISO)
trichloroacetaldehyde  (ISO)
trichloroacetic acid  (ISO)
trichloroethene  (ISO)
trichostatin A  (ISO)
triethanolamine  (ISO)
trimellitic anhydride  (ISO)
trimethyltin  (ISO)
trioxsalen  (ISO)
Triptolide  (ISO)
troglitazone  (ISO)
trovafloxacin  (EXP,ISO)
uranium atom  (EXP,ISO)
urethane  (ISO)
urocanic acid  (ISO)
ursodeoxycholic acid  (EXP,ISO)
ursolic acid  (ISO)
valdecoxib  (EXP)
valproic acid  (EXP)
vanadium atom  (ISO)
vanadium(0)  (ISO)
vancomycin  (ISO)
verbascose  (ISO)
vincristine  (ISO)
vitamin D  (EXP)
vitamin E  (EXP,ISO)
vorinostat  (ISO)
WIN 55212-2  (EXP)
wogonin  (ISO)
wortmannin  (ISO)
Y-27632  (ISO)
zafirlukast  (ISO)
zidovudine  (ISO)
zinc atom  (ISO)
zinc dichloride  (ISO)
zinc oxide  (ISO)
zinc protoporphyrin  (EXP)
zinc sulfate  (ISO)
zinc(0)  (ISO)
zingerone  (ISO)
ziram  (ISO)
zoledronic acid  (ISO)
zonisamide  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
adaptive immune response  (IBA,ISO)
antigen processing and presentation  (ISO)
apoptotic process  (ISO)
astrocyte activation  (ISO)
CD8-positive, alpha-beta T cell differentiation involved in immune response  (ISO)
cell surface receptor signaling pathway via JAK-STAT  (ISO)
cellular response to interleukin-18  (ISO)
cellular response to lipopolysaccharide  (ISO)
defense response to bacterium  (ISO)
defense response to Gram-positive bacterium  (ISO)
defense response to protozoan  (ISO)
defense response to virus  (ISO)
endoplasmic reticulum unfolded protein response  (ISO)
extrinsic apoptotic signaling pathway  (ISO)
humoral immune response  (IBA,ISO)
inflammatory cell apoptotic process  (ISO)
macrophage activation involved in immune response  (ISO)
macrophage differentiation  (ISO)
microglial cell activation  (IGI,ISO)
negative regulation of amyloid-beta clearance  (ISO)
negative regulation of cell population proliferation  (IDA)
negative regulation of DNA-templated transcription  (ISO)
negative regulation of epithelial cell differentiation  (IDA)
negative regulation of fibroblast proliferation  (IDA)
negative regulation of gene expression  (ISO)
negative regulation of glomerular mesangial cell proliferation  (IMP)
negative regulation of interleukin-17 production  (ISO)
negative regulation of myelination  (ISO)
negative regulation of osteoclast differentiation  (ISO)
negative regulation of smooth muscle cell proliferation  (ISO)
negative regulation of transcription by RNA polymerase II  (IDA)
neuroinflammatory response  (IDA)
neutrophil apoptotic process  (ISO)
neutrophil chemotaxis  (ISO)
nitric oxide biosynthetic process  (ISO)
positive regulation by host of viral process  (ISO)
positive regulation of amyloid-beta formation  (ISO)
positive regulation of apoptotic process  (IDA)
positive regulation of autophagy  (ISO,ISS)
positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation involved in immune response  (ISO)
positive regulation of cell adhesion  (IDA)
positive regulation of cell population proliferation  (IDA)
positive regulation of cellular respiration  (ISO)
positive regulation of chemokine production  (ISO)
positive regulation of cytokine production  (ISO)
positive regulation of DNA-templated transcription  (ISO)
positive regulation of epithelial cell migration  (ISO)
positive regulation of fructose 1,6-bisphosphate metabolic process  (ISO)
positive regulation of gene expression  (IDA,ISO)
positive regulation of glycolytic process  (ISO)
positive regulation of inflammatory response  (ISO)
positive regulation of interleukin-1 beta production  (ISO)
positive regulation of interleukin-12 production  (ISO)
positive regulation of interleukin-23 production  (ISO)
positive regulation of interleukin-6 production  (ISO)
positive regulation of iron ion import across plasma membrane  (ISO)
positive regulation of isotype switching to IgG isotypes  (ISO)
positive regulation of killing of cells of another organism  (ISO)
positive regulation of macrophage cytokine production  (ISO)
positive regulation of membrane protein ectodomain proteolysis  (ISO)
positive regulation of MHC class II biosynthetic process  (IEP,ISO)
positive regulation of neurogenesis  (ISO)
positive regulation of neuron differentiation  (IDA)
positive regulation of nitric oxide biosynthetic process  (ISO)
positive regulation of nitric-oxide synthase biosynthetic process  (ISO)
positive regulation of osteoclast differentiation  (ISO)
positive regulation of peptidyl-serine phosphorylation of STAT protein  (IDA,ISO)
positive regulation of phagocytosis  (ISO)
positive regulation of protein deacetylation  (ISO)
positive regulation of protein import into nucleus  (ISO)
positive regulation of protein-containing complex assembly  (ISO)
positive regulation of smooth muscle cell apoptotic process  (ISO)
positive regulation of synaptic transmission, cholinergic  (IDA)
positive regulation of T cell proliferation  (ISO)
positive regulation of transcription by RNA polymerase II  (ISO)
positive regulation of tumor necrosis factor (ligand) superfamily member 11 production  (ISO)
positive regulation of tumor necrosis factor production  (ISO)
positive regulation of tyrosine phosphorylation of STAT protein  (IDA,ISO)
positive regulation of vitamin D biosynthetic process  (ISO)
regulation of defense response to virus by host  (ISO)
regulation of DNA-templated transcription  (ISO)
regulation of glial cell proliferation  (IDA)
regulation of hepatocyte proliferation  (IDA)
regulation of immune response  (ISO)
regulation of insulin secretion  (ISO)
regulation of metabolic process  (ISO)
regulation of neuronal action potential  (IDA)
regulation of the force of heart contraction  (IDA)
response to tacrolimus  (IEP)
response to virus  (ISO)
response to xenobiotic stimulus  (IEP)
sensory perception of mechanical stimulus  (IDA)
T cell proliferation  (ISO)
T cell receptor signaling pathway  (ISO)
type II interferon-mediated signaling pathway  (ISO)
type III interferon-mediated signaling pathway  (ISO)

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
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2. Children with recurrent otitis show defective IFN gamma-producing cells in adenoids. Avanzini AM, etal., Pediatr Allergy Immunol. 2008 Sep;19(6):523-6. doi: 10.1111/j.1399-3038.2007.00682.x. Epub 2008 Feb 6.
3. Cytokine, C-Reactive Protein, and Heat Shock Protein mRNA Expression Levels in Patients with Active Behçet's Uveitis. Balkan E, etal., Med Sci Monit. 2018 Mar 13;24:1511-1516. doi: 10.12659/msm.907918.
4. PEGylation improves pharmacokinetic profile, liver uptake and efficacy of Interferon gamma in liver fibrosis. Bansal R, etal., J Control Release. 2011 Sep 25;154(3):233-40. Epub 2011 Jun 12.
5. The genetic association database. Becker KG, etal., Nat Genet. 2004 May;36(5):431-2.
6. Adenovirus-mediated interferon gamma gene therapy for allergic asthma: involvement of interleukin 12 and STAT4 signaling. Behera AK, etal., Hum Gene Ther. 2002 Sep 20;13(14):1697-709.
7. Cytokine gene expression in autoimmune thyroiditis in BioBreeding/Worcester rats. Bluher M, etal., Thyroid. 1999 Oct;9(10):1049-55.
8. The presence of IFNG 3/3 genotype in the recipient associates with increased risk for Epstein-Barr virus reactivation after allogeneic haematopoietic stem cell transplantation. Bogunia-Kubik K, etal., Br J Haematol. 2006 Feb;132(3):326-32.
9. Biphasic effect of interferon-gamma in murine collagen-induced arthritis. Boissier MC, etal., Eur J Immunol. 1995 May;25(5):1184-90.
10. Cholinergic response of isolated rat atria to recombinant rat interferon-gamma. Borda E, etal., J Neuroimmunol. 1991 Apr;32(1):53-9.
11. Altered transcription of inflammation-related genes in dental pulp of coeliac children. Bossù M, etal., Int J Paediatr Dent. 2016 Sep;26(5):351-6. doi: 10.1111/ipd.12207. Epub 2015 Oct 6.
12. Differential regulation of rodent hepatocyte and oval cell proliferation by interferon gamma. Brooling JT, etal., Hepatology. 2005 Apr;41(4):906-15.
13. Serum and urinary cytokine levels of SLE patients. Brugos B, etal., Pharmazie. 2012 May;67(5):411-3.
14. Intrarenal IFN-gamma mRNA expression differentiates clinical and subclinical glomerulitis in renal transplant recipients. Buob D, etal., Transplantation. 2011 Jul 27;92(2):170-5.
15. [Effects of leptin on airway inflammation and the expression of Th1/Th2 cytokines in asthmatic rats] Cao J, etal., Zhonghua Jie He He Hu Xi Za Zhi. 2009 Mar;32(3):171-6.
16. A dual role for interferon-gamma in the pathogenesis of Sjogren's syndrome-like autoimmune exocrinopathy in the nonobese diabetic mouse. Cha S, etal., Scand J Immunol. 2004 Dec;60(6):552-65.
17. [Single nucleotide polymorphism of interferon-gamma gene +874 T/A in patients with aplastic anemia]. Chang H, etal., Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2008 Apr;16(2):325-7.
18. Sini-san improves duodenal tight junction integrity in a rat model of functional dyspepsia. Chang X, etal., BMC Complement Altern Med. 2017 Aug 30;17(1):432. doi: 10.1186/s12906-017-1938-2.
19. Interferon-gamma (IFN-gamma) production in vivo in experimental autoimmune uveoretinitis. Charteris DG and Lightman SL, Immunology. 1992 Mar;75(3):463-7.
20. Cellular immune responses to severe acute respiratory syndrome coronavirus (SARS-CoV) infection in senescent BALB/c mice: CD4+ T cells are important in control of SARS-CoV infection. Chen J, etal., J Virol. 2010 Feb;84(3):1289-301. Epub 2009 Nov 11.
21. The interferon gamma gene polymorphism +874 A/T is associated with severe acute respiratory syndrome. Chong WP, etal., BMC Infect Dis. 2006 May 4;6:82. doi: 10.1186/1471-2334-6-82.
22. Glycine treatment decreases proinflammatory cytokines and increases interferon-gamma in patients with type 2 diabetes. Cruz M, etal., J Endocrinol Invest. 2008 Aug;31(8):694-9.
23. New associations: INFG and TGFB1 genes and the inhibitor development in severe haemophilia A. de Alencar JB, etal., Haemophilia. 2015 Jul;21(4):e312-6. doi: 10.1111/hae.12685. Epub 2015 Apr 30.
24. Dry eye-induced conjunctival epithelial squamous metaplasia is modulated by interferon-gamma. De Paiva CS, etal., Invest Ophthalmol Vis Sci. 2007 Jun;48(6):2553-60.
25. Interferon gamma expression in human nasal polyps. Dellacono FR, etal., Laryngoscope. 1997 May;107(5):626-30.
26. Protected Trypanosoma cruzi infection in rats born to mothers receiving interferon-gamma during gestation is associated with a decreased intramacrophage parasite growth and preferential synthesis of specific IgG2b antibodies. Didoli GL, etal., Int J Immunopharmacol. 2000 Jan;22(1):45-55.
27. Cloning and expression of the chromosomal immune interferon gene of the rat. Dijkema R, etal., EMBO J 1985 Mar;4(3):761-7.
28. Regulatory T cell activity is partly inhibited in a mouse model of chronic Pseudomonas aeruginosa lung infection. Ding FM, etal., Exp Lung Res. 2015 Feb;41(1):44-55. doi: 10.3109/01902148.2014.964351. Epub 2014 Nov 14.
29. Transformation of Fonsecaea pedrosoi into sclerotic cells links to the refractoriness of experimental chromoblastomycosis in BALB/c mice via a mechanism involving a chitin-induced impairment of IFN-γ production. Dong B, etal., PLoS Negl Trop Dis. 2018 Feb 26;12(2):e0006237. doi: 10.1371/journal.pntd.0006237. eCollection 2018 Feb.
30. Cell division cycle protein 42 regulates the inflammatory response in mice bearing inflammatory bowel disease. Dong LM, etal., Artif Cells Nanomed Biotechnol. 2019 Dec;47(1):1833-1838. doi: 10.1080/21691401.2019.1596936.
31. A dual role for the immune response in a mouse model of inflammation-associated lung cancer. Dougan M, etal., J Clin Invest. 2011 Jun 1;121(6):2436-46. doi: 10.1172/JCI44796. Epub 2011 May 2.
32. Interleukin-6 Serum Levels Are Elevated in Individuals with Degenerative Cervical Myelopathy and Are Correlated with Symptom Severity. Du S, etal., Med Sci Monit. 2018 Oct 17;24:7405-7413. doi: 10.12659/MSM.912868.
33. C-terminal truncation of IFN-γ inhibits proinflammatory macrophage responses and is deficient in autoimmune disease. Dufour A, etal., Nat Commun. 2018 Jun 20;9(1):2416. doi: 10.1038/s41467-018-04717-4.
34. Homozygosis for (12) CA repeats in the first intron of the human IFN-gamma gene is significantly associated with the risk of aplastic anaemia in Caucasian population. Dufour C, etal., Br J Haematol. 2004 Sep;126(5):682-5.
35. Involvement of interferon-gamma genetic variants and intercellular adhesion molecule-1 in onset and progression of generalized vitiligo. Dwivedi M, etal., J Interferon Cytokine Res. 2013 Nov;33(11):646-59. doi: 10.1089/jir.2012.0171. Epub 2013 Jun 18.
36. Expression of interferon-gamma in the lens exacerbates anterior uveitis and induces retinal degenerative changes in transgenic Lewis rats. Egwuagu CE, etal., Clin Immunol. 1999 May;91(2):196-205.
37. Cytokine profiles in aqueous humor of patients with different clinical entities of endogenous uveitis. El-Asrar AM, etal., Clin Immunol. 2011 May;139(2):177-84. doi: 10.1016/j.clim.2011.01.014. Epub 2011 Jan 31.
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181. Expression of tumor necrosis factor-alpha, interleukin-6, and interferon-gamma in spontaneous chronic pancreatitis in the WBN/Kob rat. Xie MJ, etal., Pancreas. 2001 May;22(4):400-8.
182. Exploration of the Correlations Between Interferon-gamma in Patient Serum and HEPACAM in Bladder Transitional Cell Carcinoma, and the Interferon-gamma Mechanism Inhibiting BIU-87 Proliferation. Xu B, etal., J Urol. 2012 Aug 17.
183. Adenovirus-mediated interferon-gamma transfer inhibits growth of transplanted HTLV-1 Tax tumors in mice. Xu X, etal., Hum Gene Ther. 1996 Mar 1;7(4):471-7.
184. Intrathecal interferon-gamma facilitates the spinal nociceptive flexor reflex in the rat. Xu XJ, etal., Neurosci Lett. 1994 Dec 5;182(2):263-6.
185. Elevated IL-23R Expression and Foxp3+Rorgt+ Cells in Intestinal Mucosa During Acute and Chronic Colitis. Yang J and Xu L, Med Sci Monit. 2016 Aug 8;22:2785-92. doi: 10.12659/msm.896827.
186. Persistent memory CD4+ and CD8+ T-cell responses in recovered severe acute respiratory syndrome (SARS) patients to SARS coronavirus M antigen. Yang L, etal., J Gen Virol. 2007 Oct;88(Pt 10):2740-8. doi: 10.1099/vir.0.82839-0.
187. Long-lived effector/central memory T-cell responses to severe acute respiratory syndrome coronavirus (SARS-CoV) S antigen in recovered SARS patients. Yang LT, etal., Clin Immunol. 2006 Aug;120(2):171-8. doi: 10.1016/j.clim.2006.05.002. Epub 2006 Jun 16.
188. Interferon gamma immunoreactivity in iris nerve fibres during endotoxin induced uveitis in the rat. Yang P, etal., Br J Ophthalmol. 1998 Jun;82(6):695-9.
189. Interferon-gamma improves renal interstitial fibrosis and decreases intrarenal vascular resistance of hydronephrosis in an animal model. Yao Y, etal., Urology. 2011 Mar;77(3):761.e8-13. Epub 2011 Jan 8.
190. [Clinical features of chronic granulomatous disease]. Ying WJ, etal., Zhonghua Er Ke Za Zhi. 2012 May;50(5):380-5.
191. Increased peripheral blood interferon gamma-producing T cells in acute disseminated encephalomyelitis. Yoshitomi T, etal., J Neuroimmunol. 2000 Nov 1;111(1-2):224-8.
192. Neural Stem/Progenitor Cells Differentiate In Vitro to Neurons by the Combined Action of Dibutyryl cAMP and Interferon-gamma. Zahir T, etal., Stem Cells Dev. 2009 Apr 8.
193. Effect of selenium on pancreatic proinflammatory cytokines in streptozotocin-induced diabetic mice. Zeng J, etal., J Nutr Biochem. 2009 Jul;20(7):530-6. Epub 2008 Sep 11.
194. Silencing of microRNA-494 inhibits the neurotoxic Th1 shift via regulating HDAC2-STAT4 cascade in ischaemic stroke. Zhao H, etal., Br J Pharmacol. 2020 Jan;177(1):128-144. doi: 10.1111/bph.14852. Epub 2019 Nov 8.
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197. Determinants of the immune response in visceral leishmaniasis: evidence for predominance of endogenous interleukin 4 over interferon-gamma production. Zwingenberger K, etal., Clin Immunol Immunopathol. 1990 Nov;57(2):242-9.
Additional References at PubMed
PMID:1845803   PMID:2493384   PMID:2502420   PMID:3093809   PMID:7544003   PMID:7605994   PMID:7715705   PMID:7828849   PMID:8383325   PMID:8557999   PMID:9282826   PMID:9348310  
PMID:10072077   PMID:11027433   PMID:11057672   PMID:11168643   PMID:11457893   PMID:11487543   PMID:11698262   PMID:11728336   PMID:11770039   PMID:11894098   PMID:11911824   PMID:11954833  
PMID:12050152   PMID:12581489   PMID:12668667   PMID:12882831   PMID:12925700   PMID:12968017   PMID:14568984   PMID:14605445   PMID:14978081   PMID:15012733   PMID:15087456   PMID:15115662  
PMID:15220916   PMID:15240714   PMID:15240719   PMID:15356141   PMID:15604419   PMID:15694390   PMID:15721283   PMID:15843532   PMID:15911877   PMID:15944262   PMID:15946996   PMID:16002150  
PMID:16095488   PMID:16177108   PMID:16220542   PMID:16275384   PMID:16280321   PMID:16289836   PMID:16464236   PMID:16521127   PMID:16769892   PMID:16942485   PMID:17082577   PMID:17255335  
PMID:17277142   PMID:17278885   PMID:17442941   PMID:17658279   PMID:17969033   PMID:17981803   PMID:18025219   PMID:18292182   PMID:18343154   PMID:18373975   PMID:18375019   PMID:18501882  
PMID:18547159   PMID:18791161   PMID:18818381   PMID:18826099   PMID:18997793   PMID:19050265   PMID:19139201   PMID:19176616   PMID:19257980   PMID:19423618   PMID:19426591   PMID:19606498  
PMID:19666510   PMID:19710466   PMID:19781632   PMID:19808651   PMID:19838199   PMID:19922500   PMID:20003332   PMID:20027291   PMID:20041150   PMID:20064371   PMID:20209097   PMID:20214528  
PMID:20368278   PMID:20378828   PMID:20399120   PMID:20559421   PMID:20706986   PMID:20889566   PMID:20956546   PMID:21123181   PMID:21217760   PMID:21385594   PMID:21444916   PMID:21460847  
PMID:21606376   PMID:21613615   PMID:21641126   PMID:21709260   PMID:22301113   PMID:22302831   PMID:22338606   PMID:22504299   PMID:23629966   PMID:23817958   PMID:24188094   PMID:24338258  
PMID:24571083   PMID:24784232   PMID:25268627   PMID:26227742   PMID:26347139   PMID:26610752   PMID:26987263   PMID:27104804   PMID:27579780   PMID:28025796   PMID:28092075   PMID:28487237  
PMID:28714001   PMID:29061364   PMID:29469038   PMID:30511618   PMID:30634164   PMID:30756238   PMID:31341902   PMID:32448218   PMID:37260264  


Genomics

Comparative Map Data
Ifng
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8755,789,180 - 55,793,216 (+)NCBIGRCr8
mRatBN7.2753,903,339 - 53,907,375 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl753,903,337 - 53,907,375 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx755,810,041 - 55,814,077 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0758,013,127 - 58,017,163 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0757,790,977 - 57,795,013 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0761,337,383 - 61,341,419 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl761,337,381 - 61,341,419 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0761,333,604 - 61,337,640 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4757,621,756 - 57,625,792 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1757,642,485 - 57,646,522 (+)NCBI
Celera750,671,237 - 50,675,273 (+)NCBICelera
RH 3.4 Map7479.11RGD
Cytogenetic Map7q22NCBI
IFNG
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381268,154,768 - 68,159,740 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1268,154,768 - 68,159,740 (-)EnsemblGRCh38hg38GRCh38
GRCh371268,548,548 - 68,553,520 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361266,834,817 - 66,839,788 (-)NCBINCBI36Build 36hg18NCBI36
Build 341266,834,816 - 66,839,788NCBI
Celera1268,212,600 - 68,217,569 (-)NCBICelera
Cytogenetic Map12q15NCBI
HuRef1265,599,188 - 65,604,157 (-)NCBIHuRef
CHM1_11268,516,525 - 68,521,498 (-)NCBICHM1_1
T2T-CHM13v2.01268,134,280 - 68,139,252 (-)NCBIT2T-CHM13v2.0
Ifng
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3910118,276,951 - 118,281,799 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl10118,276,951 - 118,281,797 (+)EnsemblGRCm39 Ensembl
GRCm3810118,441,046 - 118,445,894 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl10118,441,046 - 118,445,892 (+)EnsemblGRCm38mm10GRCm38
MGSCv3710117,878,103 - 117,882,948 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3610117,844,040 - 117,848,885 (+)NCBIMGSCv36mm8
Celera10120,821,579 - 120,826,426 (+)NCBICelera
Cytogenetic Map10D2NCBI
cM Map1066.75NCBI
Ifng
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495545814,643,313 - 14,648,045 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495545814,643,333 - 14,648,020 (-)NCBIChiLan1.0ChiLan1.0
IFNG
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21076,170,643 - 76,175,506 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11276,167,040 - 76,171,890 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01265,663,764 - 65,668,732 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11268,448,861 - 68,453,829 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1268,448,861 - 68,453,829 (-)Ensemblpanpan1.1panPan2
IFNG
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11010,406,866 - 10,411,698 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1010,406,867 - 10,411,698 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1010,340,127 - 10,344,948 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01010,530,420 - 10,535,258 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1010,530,421 - 10,535,258 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11010,399,244 - 10,404,067 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01010,645,481 - 10,650,291 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01010,768,058 - 10,772,882 (-)NCBIUU_Cfam_GSD_1.0
Ifng
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494547,965,684 - 47,971,000 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365456,139,116 - 6,148,452 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365456,139,130 - 6,144,543 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
IFNG
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl532,477,906 - 32,482,670 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1532,477,906 - 32,482,670 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2535,374,421 - 35,379,185 (+)NCBISscrofa10.2Sscrofa10.2susScr3
Pig Cytomap5p1.2-q1.1NCBI
IFNG
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11163,785,493 - 63,791,071 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1163,786,041 - 63,790,473 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666037181,915,432 - 181,941,492 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ifng
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624802163,261 - 166,534 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624802163,261 - 166,534 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Ifng
11 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:53
Count of miRNA genes:43
Interacting mature miRNAs:48
Transcripts:ENSRNOT00000009919
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
634336Anxrr17Anxiety related response QTL 173.66locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)7924703115097879Rat
2298547Neuinf5Neuroinflammation QTL 53.7nervous system integrity trait (VT:0010566)spinal cord Cd74 protein level (CMO:0002131)7946224658265113Rat
1643004Pain2Pain QTL 21mechanical nociception trait (VT:0002734)self mutilation severity score (CMO:0002145)7946224698011544Rat
1578652Bmd15Bone mineral density QTL 155.2femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)7986646760460686Rat
738033Anxrr6Anxiety related response QTL 64.1exploratory behavior trait (VT:0010471)percentage of entries into a discrete space in an experimental apparatus (CMO:0000961)71557388960573889Rat
2317059Aia15Adjuvant induced arthritis QTL 152.46joint integrity trait (VT:0010548)right rear ankle joint diameter (CMO:0002150)71700459862004598Rat
10755451Coatc11Coat color QTL 110coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)71794435762944357Rat
1300132Bp182Blood pressure QTL 1823.49arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)71965431784928080Rat
7411569Bw137Body weight QTL 1370.001body mass (VT:0001259)body weight gain (CMO:0000420)72192119566921195Rat
1641885Alcrsp9Alcohol response QTL 9alcohol metabolism trait (VT:0015089)blood ethanol level (CMO:0000535)72409960669099606Rat
1549840Bss5Bone structure and strength QTL 59.8femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)72475184169751841Rat
70190Mcs6Mammary carcinoma susceptibility QTL 62.29mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)72673740163902784Rat
10402855Bp379Blood pressure QTL 3790.21arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)72940968374409683Rat
1300127Srn1Serum renin concentration QTL 13.87blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)72940968384928080Rat
10755453Coatc12Coat color QTL 120coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)73111283276112832Rat
7411605Foco14Food consumption QTL 1424.10.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)73429328279293282Rat
631534Lnnr1Liver neoplastic nodule remodeling QTL 13.850.001liver integrity trait (VT:0010547)liver remodeling tumorous lesion number to liver total tumorous lesion number ratio (CMO:0001705)73429328279293282Rat
631513Scl7Serum cholesterol level QTL 74.1blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)73796056982960569Rat
2303629Vencon3Ventilatory control QTL 37.25respiration trait (VT:0001943)respiration rate (CMO:0000289)74110969256793354Rat
61357Bp38Blood pressure QTL 381.60.052arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)741333674119109060Rat
634326Hc3Hypercalciuria QTL 32.1urine calcium amount (VT:0002985)urine calcium excretion rate (CMO:0000763)74278731487787314Rat
10053722Scort27Serum corticosterone level QTL 272.410.0083blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)74322875088228750Rat
1358361Sradr5Stress Responsive Adrenal Weight QTL 55.55adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)743747012108555253Rat
1300179Kidm5Kidney mass QTL 53.51kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)743747012135012528Rat
1300149Cm6Cardiac mass QTL 64.09heart mass (VT:0007028)heart left ventricle weight to body weight ratio (CMO:0000530)743747099102228765Rat
631504Cm27Cardiac mass QTL 273.45heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)744421311118198041Rat
61428Scl3Serum cholesterol level QTL 33.2blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)74486753389867533Rat
738030Anxrr8Anxiety related response QTL 84.1exploratory behavior trait (VT:0010471)number of entries into a discrete space in an experimental apparatus (CMO:0000960)74659007091590070Rat
10059605Kidm47Kidney mass QTL 472.910.05kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)74725178365728867Rat
2293696Bmd32Bone mineral density QTL 325.10.0001femur strength trait (VT:0010010)femoral neck polar moment of inertia (CMO:0001670)74765143992651439Rat
2293707Bss32Bone structure and strength QTL 327.640.0001femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)74765143992651439Rat
2300178Bmd54Bone mineral density QTL 545.30.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)74765143992651439Rat
2293644Bmd29Bone mineral density QTL 295.40.0001femur size trait (VT:1000369)femoral neck cross-sectional area (CMO:0001697)74765143992651439Rat
2293667Bss42Bone structure and strength QTL 427.250.0001lumbar vertebra size trait (VT:0010518)lumbar vertebra cross-sectional area (CMO:0001689)74765143992651439Rat
2293678Bss24Bone structure and strength QTL 246.710.0001femur morphology trait (VT:0000559)femur cross-sectional area (CMO:0001661)74765143992651439Rat
2293685Bmd21Bone mineral density QTL 214.20.0003femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)74765143992651439Rat
1300151Bp181Blood pressure QTL 1813.36arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)753612714103945643Rat

Markers in Region
RH94844  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2753,904,858 - 53,905,040 (+)MAPPERmRatBN7.2
Rnor_6.0761,338,903 - 61,339,084NCBIRnor6.0
Rnor_5.0761,335,124 - 61,335,305UniSTSRnor5.0
RGSC_v3.4757,623,276 - 57,623,457UniSTSRGSC3.4
Celera750,672,757 - 50,672,938UniSTS
RH 3.4 Map7479.11UniSTS
Cytogenetic Map7q22UniSTS
RH94845  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2753,904,868 - 53,905,058 (+)MAPPERmRatBN7.2
Rnor_6.0761,338,913 - 61,339,102NCBIRnor6.0
Rnor_5.0761,335,134 - 61,335,323UniSTSRnor5.0
RGSC_v3.4757,623,286 - 57,623,475UniSTSRGSC3.4
Celera750,672,767 - 50,672,956UniSTS
Cytogenetic Map7q22UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium
Low 2 3 8 18 13 4
Below cutoff 12 11 7 1 7 1 1 2 4 10 3 1

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000009919   ⟹   ENSRNOP00000009917
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl753,903,337 - 53,907,375 (+)Ensembl
Rnor_6.0 Ensembl761,337,381 - 61,341,419 (+)Ensembl
RefSeq Acc Id: NM_138880   ⟹   NP_620235
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8755,789,180 - 55,793,216 (+)NCBI
mRatBN7.2753,903,339 - 53,907,375 (+)NCBI
Rnor_6.0761,337,383 - 61,341,419 (+)NCBI
Rnor_5.0761,333,604 - 61,337,640 (+)NCBI
RGSC_v3.4757,621,756 - 57,625,792 (+)RGD
Celera750,671,237 - 50,675,273 (+)RGD
Sequence:
Reference Protein Sequences
RefSeq Acc Id: NP_620235   ⟸   NM_138880
- Peptide Label: precursor
- UniProtKB: P01581 (UniProtKB/Swiss-Prot),   A0A7R8C3J6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000009917   ⟸   ENSRNOT00000009919

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P01581-F1-model_v2 AlphaFold P01581 1-156 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2866 AgrOrtholog
BioCyc Gene G2FUF-33942 BioCyc
Ensembl Genes ENSRNOG00000007468 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
  ENSRNOG00055012332 UniProtKB/Swiss-Prot
  ENSRNOG00060008537 UniProtKB/Swiss-Prot
  ENSRNOG00065013127 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000009919 ENTREZGENE
  ENSRNOT00000009919.3 UniProtKB/Swiss-Prot
  ENSRNOT00055020995 UniProtKB/Swiss-Prot
  ENSRNOT00060014240 UniProtKB/Swiss-Prot
  ENSRNOT00065021518 UniProtKB/Swiss-Prot
Gene3D-CATH 1.20.1250.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro 4_helix_cytokine-like_core UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Interferon_gamma UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:25712 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene 25712 ENTREZGENE
PANTHER INTERFERON GAMMA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR11419 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam IFN-gamma UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB IFNG RGD
PhenoGen Ifng PhenoGen
PIRSF IFN-gamma UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE PROKAR_LIPOPROTEIN UniProtKB/TrEMBL
RatGTEx ENSRNOG00000007468 RatGTEx
  ENSRNOG00055012332 RatGTEx
  ENSRNOG00060008537 RatGTEx
  ENSRNOG00065013127 RatGTEx
Superfamily-SCOP SSF47266 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A7R8C3J6 ENTREZGENE, UniProtKB/TrEMBL
  IFNG_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2002-06-10 Ifng  Interferon gamma      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_process inhibits bleomycin (BM)-induced pulmonary fibrosis 729234