GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Ifng | decreases expression | ISO | IFNG (Homo sapiens) | 6480464 | CTD | Tretinoin results in decreased expression of IFNG mRNA; Tretinoin results in decreased expression of IFNG protein | PMID:15189689 PMID:16292516 PMID:16872382 PMID:17107666 PMID:17118196 | Ifng | decreases secretion | ISO | IFNG (Homo sapiens) | 6480464 | CTD | Tretinoin results in decreased secretion of IFNG protein | PMID:16872382 | Ifng | decreases secretion | ISO | Ifng (Mus musculus) | 6480464 | CTD | Tretinoin results in decreased secretion of IFNG protein | PMID:11970994 | Ifng | multiple interactions | ISO | IFNG (Homo sapiens) | 6480464 | CTD | [IFNG protein co-treated with Tretinoin] affects the expression of HLA-DRA protein; [IFNG protein co-treated with Tretinoin] results in increased expression of FAS mRNA; [IFNG protein co-treated with Tretinoin] results in increased expression of FAS protein; [Tretinoin co-treated with IFNG protein] results in decreased expression of BCL2 protein; [Tretinoin co-treated with IFNG protein] results in decreased expression of CDK2 protein; [Tretinoin co-treated with IFNG protein] results in increased activity of CASP3 protein; [Tretinoin co-treated with IFNG protein] results in increased cleavage of DFFA protein; [Tretinoin co-treated with IFNG protein] results in increased expression of BAX protein; [Tretinoin co-treated with IFNG protein] results in increased expression of CDKN1B protein; [Tretinoin co-treated with IFNG protein] results in increased expression of PTEN protein; Dactinomycin inhibits the reaction [Tretinoin promotes the reaction [IFNG protein results in increased expression of IRF1 protein]]; IFNG protein inhibits the reaction [Tretinoin results in increased expression of MUC4 mRNA]; IFNG protein inhibits the reaction [Tretinoin results in increased expression of MUC4 protein]; IFNG protein inhibits the reaction [Tretinoin results in increased expression of TGFB2 mRNA]; IFNG protein promotes the reaction [Tretinoin results in increased expression of IRF1 protein]; IFNG protein promotes the reaction [Tretinoin results in increased expression of RARA mRNA]; IFNG protein promotes the reaction [Tretinoin results in increased expression of RARG mRNA]; RARA protein affects the reaction [Tretinoin results in decreased secretion of IFNG protein]; Ro 41-5253 inhibits the reaction [IFNG protein promotes the reaction [Tretinoin results in increased expression of MUC4 protein]]; Ro 41-5253 inhibits the reaction [Tretinoin results in decreased secretion of IFNG protein]; Tretinoin inhibits the reaction [IFNG protein results in increased expression of STAT1 protein]; Tretinoin inhibits the reaction [IFNG protein results in increased phosphorylation of STAT1 protein]; Tretinoin promotes the reaction [IFNG protein promotes the reaction [IRF1 protein results in increased expression of CASP1 mRNA]]; Tretinoin promotes the reaction [IFNG protein promotes the reaction [IRF1 protein results in increased expression of TNFSF10 mRNA]]; Tretinoin promotes the reaction [IFNG protein results in increased expression of and results in increased localization of and results in increased activity of IRF1 protein]; Tretinoin promotes the reaction [IFNG protein results in increased expression of CASP1 mRNA]; Tretinoin promotes the reaction [IFNG protein results in increased expression of TNFSF10 mRNA]; Tretinoin promotes the reaction [IFNG protein results in increased phosphorylation of and results in increased activity of STAT1 protein] | PMID:16007204 PMID:16085646 PMID:16136269 PMID:16636311 PMID:16872382 PMID:16947022 PMID:17960384 | | ||||||||||||||||||||||
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