GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2866
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Ifng
Name: interferon gamma
Acc ID: CHEBI:27881
Term: resveratrol
Definition: A stilbenol that has formula C14H12O3.
CasRN: 501-36-0
Chemical ID: MESH:C059514
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
multiple interactionsISORGD:7374886480464CTDresveratrol inhibits the reaction [[[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of NOS2 mRNA] which results in increased chemical synthesis of Nitric Oxide]

PMID:11020457
multiple interactionsISORGD:7374876480464CTDresveratrol inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased abundance of Nitric Oxide]

PMID:22698256
multiple interactionsISORGD:7374876480464CTDresveratrol inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of IL8 mRNA]

resveratrol inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of IL8 protein]

resveratrol inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of PTGES2 protein]

resveratrol inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of TNF protein]

resveratrol inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of TNF mRNA]

PMID:15779068
multiple interactionsISORGD:7374876480464CTDresveratrol inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of IFNG protein]

PMID:16154495
multiple interactionsISORGD:7374886480464CTDresveratrol affects the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of and results in increased secretion of IFNG protein]

PMID:16716911
decreases expressionISORGD:7374886480464CTDresveratrol results in decreased expression of IFNG protein

PMID:16256029
PMID:17872969
decreases expressionISORGD:7374886480464CTDresveratrol results in decreased expression of IFNG mRNA

PMID:16256029
multiple interactionsEXP 6480464CTDresveratrol inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein co-treated with TNF protein] results in increased abundance of Nitric Oxide]

resveratrol inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein co-treated with TNF protein] results in increased abundance of Reactive Oxygen Species]

resveratrol inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein co-treated with TNF protein] results in increased expression of NOS2 mRNA]

resveratrol inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein co-treated with TNF protein] results in increased expression of NOS2 protein]

resveratrol promotes the reaction [[Lipopolysaccharides co-treated with IFNG protein co-treated with TNF protein] results in increased expression of SOD2 protein]

PMID:16366677
decreases expressionISORGD:7374886480464CTDresveratrol results in decreased expression of IFNG protein

PMID:17872969
PMID:16256029
multiple interactionsISORGD:7374876480464CTDresveratrol inhibits the reaction [[TNF protein co-treated with IFNG protein] results in increased phosphorylation of RELA protein]

resveratrol inhibits the reaction [[TNF protein co-treated with IFNG protein] results in increased phosphorylation of MAPK1 protein]

resveratrol inhibits the reaction [[TNF protein co-treated with IFNG protein] results in increased phosphorylation of MAPK3 protein]

resveratrol inhibits the reaction [[TNF protein co-treated with IFNG protein] results in increased secretion of CXCL10 protein]

resveratrol promotes the reaction [[TNF protein co-treated with IFNG protein] results in increased secretion of IL8 protein]

PMID:21756928
decreases expressionISORGD:7374876480464CTDresveratrol results in decreased expression of IFNG mRNA

PMID:21371465
affects expressionISORGD:7374886480464CTDresveratrol affects the expression of IFNG protein

PMID:20730501
multiple interactionsISORGD:7374876480464CTDresveratrol inhibits the reaction [[TNF protein co-treated with IFNG protein co-treated with lipopolysaccharide, Escherichia coli 0111 B4] results in increased expression of NOS2 protein]

resveratrol inhibits the reaction [[TNF protein co-treated with IFNG protein co-treated with lipopolysaccharide, Escherichia coli 0111 B4] results in increased expression of PTGS2 protein]

PMID:19549798
multiple interactionsISORGD:7374886480464CTDresveratrol inhibits the reaction [Dextran Sulfate results in increased expression of IFNG protein]

PMID:19940103
multiple interactionsISORGD:7374886480464CTDresveratrol inhibits the reaction [Ethanol results in increased activity of IFNG protein]

PMID:21086752
decreases expressionISORGD:7374886480464CTDresveratrol results in decreased expression of IFNG mRNA

PMID:16256029
PMID:21340626
decreases expressionISORGD:7374886480464CTDresveratrol results in decreased expression of IFNG protein

PMID:16256029
PMID:17872969
PMID:21340626
multiple interactionsISORGD:7374886480464CTDresveratrol inhibits the reaction [IFNG protein results in increased abundance of Nitric Oxide]

PMID:20424383
decreases expressionISORGD:7374886480464CTDresveratrol results in decreased expression of IFNG protein

PMID:16256029
PMID:17872969
PMID:21340626
PMID:21807089
PMID:21937650
multiple interactionsISORGD:7374876480464CTD[IFNG protein results in increased expression of and results in increased localization of FAS protein] which results in increased susceptibility to resveratrol

PMID:19561642
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