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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2866
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Ifng
Name: interferon gamma
Acc ID: CHEBI:47807
Term: sulforaphane
Definition: An isothiocyanate having a 4-(methylsulfinyl)butyl group attached to the nitrogen.
Chemical ID: MESH:C016766
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Ifngmultiple interactionsEXP 6480464CTDsulforaphane inhibits the reaction [[IL1B protein co-treated with IFNG protein] inhibits the reaction [Glucose results in increased secretion of INS1 protein]]; sulforaphane inhibits the reaction [[IL1B protein co-treated with IFNG protein] results in increased abundance of Dinoprostone]; sulforaphane inhibits the reaction [[IL1B protein co-treated with IFNG protein] results in increased abundance of Nitrites]; sulforaphane inhibits the reaction [[IL1B protein co-treated with IFNG protein] results in increased expression of NOS2 mRNA]; sulforaphane inhibits the reaction [[IL1B protein co-treated with IFNG protein] results in increased expression of NOS2 protein]; sulforaphane inhibits the reaction [[IL1B protein co-treated with IFNG protein] results in increased expression of PTGS2 mRNA]; sulforaphane inhibits the reaction [[IL1B protein co-treated with IFNG protein] results in increased expression of PTGS2 protein]PMID:19071154
Ifngdecreases activityISOIfng (Mus musculus)6480464CTDsulforaphane results in decreased activity of IFNG proteinPMID:19071154
Ifngmultiple interactionsISOIfng (Mus musculus)6480464CTDsulforaphane inhibits the reaction [[[ALB protein binds to 4-hydroxy-2-nonenal] which results in increased susceptibility to Trichloroethylene] which results in increased secretion of IFNG protein]; sulforaphane inhibits the reaction [[IL1B protein co-treated with IFNG protein] affects the localization of NFKB1 protein]; sulforaphane inhibits the reaction [[IL1B protein co-treated with IFNG protein] affects the localization of RELA protein]; sulforaphane inhibits the reaction [[IL1B protein co-treated with IFNG protein] results in increased abundance of Dinoprostone]; sulforaphane inhibits the reaction [[IL1B protein co-treated with IFNG protein] results in increased abundance of Hydrogen Peroxide]; sulforaphane inhibits the reaction [[IL1B protein co-treated with IFNG protein] results in increased abundance of Nitrites]; sulforaphane inhibits the reaction [[IL1B protein co-treated with IFNG protein] results in increased expression of NOS2 mRNA]; sulforaphane inhibits the reaction [[IL1B protein co-treated with IFNG protein] results in increased expression of NOS2 protein]; sulforaphane inhibits the reaction [[IL1B protein co-treated with IFNG protein] results in increased expression of PTGS2 mRNA]; sulforaphane inhibits the reaction [[IL1B protein co-treated with IFNG protein] results in increased expression of PTGS2 protein]; sulforaphane inhibits the reaction [[IL1B protein co-treated with IFNG protein] results in increased phosphorylation of NFKBIA protein]; sulforaphane inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of CASP1 protein]; sulforaphane inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of IL1B protein]; sulforaphane inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of IL6 protein]; sulforaphane inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of ITGAM protein]; sulforaphane inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of NLRP3 protein]; sulforaphane inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of PYCARD protein]; sulforaphane inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of TNF protein]; sulforaphane inhibits the reaction [IFNG protein results in increased abundance of Nitrites]; tin protoporphyrin IX inhibits the reaction [sulforaphane inhibits the reaction [IFNG protein results in increased abundance of Nitrites]]PMID:19071154 PMID:23942037 PMID:33007382 PMID:36988325
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