RGD Reference Report - A differential association of interferon-gamma high-producing allele T and low-producing allele A (+874 A/T) with Hashimoto's thyroiditis and Graves' disease.

General

A differential association of interferon-gamma high-producing allele T and low-producing allele A (+874 A/T) with Hashimoto's thyroiditis and Graves' disease.
Authors:	Rekha, PL Ishaq, M Valluri, V
Citation:	Rekha PL, etal., Scand J Immunol. 2006 Oct;64(4):438-43.
RGD ID:	8157599
Pubmed:	PMID:16970687 (View Abstract at PubMed)
DOI:	DOI:10.1111/j.1365-3083.2006.01834.x (Journal Full-text)
Cytokines play a crucial role in the pathogenesis of autoimmune thyroid disease. The aim of this study was to investigate the relationship of the single base change polymorphic variants identified in the first intron of interferon-gamma (IFN-gamma) (+874 T/A) with susceptibility to thyroid dysfunctions. A total of 340 subjects were included in the study comprising of 190 patients (104 patients with Hashimoto's thyroiditis, 26 with non-Hashimoto's hypothyroidism and 60 Graves' disease) and 150 controls. Genotyping was done by amplification refractory mutation system-polymerase chain reaction using a set of sequence-specific primers. Statistical analysis revealed a significant association between high IFN-gamma-producing genotype TT and Hashimoto's thyroiditis compared to controls (P value < 0.001). On the other hand, the frequency of genotype TT was decreased in patients with Graves' hyperthyroidism with a significant increase in low IFN-gamma-producing genotype AA among this group (P = 0.03). To conclude the results of the study suggest a differential association of high- and low-producing alleles of IFN-gamma gene with Hashimoto's thyroiditis and Graves' disease. The high IFN-gamma-producing allele T was observed to be associated with Hashimoto's thyroiditis in the present study where as in Graves' hyperthyroidism the association was observed to be stronger with the low producing allele A.

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Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
Chronic Thyroiditis	susceptibility	IAGP		8157599	DNA:polymorphism:cds:+874A>T(human)	RGD
Chronic Thyroiditis	susceptibility	ISO	IFNG (Homo sapiens)	8157599; 8157599	DNA:polymorphism:cds:+874A>T(human)	RGD
Graves' disease	susceptibility	IAGP		8157599	DNA:polymorphism:cds:+874A>T(human)	RGD
Graves' disease	susceptibility	ISO	IFNG (Homo sapiens)	8157599; 8157599	DNA:polymorphism:cds:+874A>T(human)	RGD

Objects Annotated

Genes (Rattus norvegicus)

Ifng (interferon gamma)

Genes (Mus musculus)

Ifng (interferon gamma)

Genes (Homo sapiens)

IFNG (interferon gamma)

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A differential association of interferon-gamma high-producing allele T and low-producing allele A (+874 A/T) with Hashimoto's thyroiditis and Graves' disease.