RGD Reference Report - Phenotypic and functional changes of cytotoxic CD56pos natural T cells determine outcome of acute hepatitis C virus infection. - Rat Genome Database

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Phenotypic and functional changes of cytotoxic CD56pos natural T cells determine outcome of acute hepatitis C virus infection.

Authors: Golden-Mason, Lucy  Castelblanco, Nicole  O'Farrelly, Cliona  Rosen, Hugo R 
Citation: Golden-Mason L, etal., J Virol. 2007 Sep;81(17):9292-8. doi: 10.1128/JVI.00834-07. Epub 2007 Jun 6.
RGD ID: 40400745
Pubmed: PMID:17553896   (View Abstract at PubMed)
PMCID: PMC1951454   (View Article at PubMed Central)
DOI: DOI:10.1128/JVI.00834-07   (Journal Full-text)

Innate CD56(pos) natural killer (NK) and natural T (NT) cells comprise important hepatic antiviral effector lymphocytes whose activity is fine-tuned through surface NK receptors (NKRs). Dysregulation of NKRs in patients with long-standing hepatitis C virus (HCV) infection has been shown, but little is known regarding NKRs in acute infection. Treatment-naïve patients with acute HCV (n = 22), including 10 with spontaneous recovery, were prospectively studied. CD56(pos) NT levels were reduced early in acute HCV infection and did not fluctuate over time. In resolving HCV infection, NT cells with a more activated phenotype (lower CD158A and higher natural cytotoxicity receptor expression) at baseline predated spontaneous recovery. Moreover, NKG2A expression on CD56(+) NT cells correlated directly with circulating HCV RNA levels. Deficient interleukin-13 (IL-13) production by NT cells and reduced IL-2-activated killing (LAK) at baseline were associated with the ultimate development of persistence. These results indicate a previously unappreciated role for NT cells in acute HCV infection and identify a potential target for pharmacologic manipulation.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
hepatitis C  IEP 40400745protein:increased expression:peripheral blood mononuclear cell and natural killer cell (human)RGD 
hepatitis C disease_progressionIEP 40400745; 40400745; 40400745protein:increased expression:peripheral blood mononuclear cell and natural killer cell (human)RGD 
hepatitis C  IEP 40400745; 40400745protein:decreased expression:peripheral blood mononuclear cell and natural killer cell (human)RGD 
hepatitis C  ISOIFNG (Homo sapiens)40400745; 40400745protein:increased expression:peripheral blood mononuclear cell and natural killer cell (human)RGD 
hepatitis C disease_progressionISOIL13 (Homo sapiens)40400745; 40400745protein:increased expression:peripheral blood mononuclear cell and natural killer cell (human)RGD 
hepatitis C  ISOIL13 (Homo sapiens)40400745; 40400745protein:decreased expression:peripheral blood mononuclear cell and natural killer cell (human)RGD 
hepatitis C  ISOIL2 (Homo sapiens)40400745; 40400745protein:decreased expression:peripheral blood mononuclear cell and natural killer cell (human)RGD 
hepatitis C  IEP 40400745protein:increased expression:peripheral blood mononuclear cell and natural killer cRGD 
hepatitis C disease_progressionIEP 40400745protein:increased expression:peripheral blood mononuclear cell and natural killer cRGD 
hepatitis C disease_progressionISOKLRC1 (Homo sapiens)40400745; 40400745protein:increased expression:peripheral blood mononuclear cell and natural killer cRGD 
hepatitis C disease_progressionISONCR1 (Homo sapiens)40400745; 40400745protein:increased expression:peripheral blood mononuclear cell and natural killer cell (human)RGD 
hepatitis C disease_progressionISONCR3 (Homo sapiens)40400745; 40400745protein:increased expression:peripheral blood mononuclear cell and natural killer cell (human)RGD 

Objects Annotated

Genes (Rattus norvegicus)
Ifng  (interferon gamma)
Il13  (interleukin 13)
Il2  (interleukin 2)
Klrc1  (killer cell lectin like receptor C1)
Ncr1  (natural cytotoxicity triggering receptor 1)
Ncr3  (natural cytotoxicity triggering receptor 3)

Genes (Mus musculus)
Ifng  (interferon gamma)
Il13  (interleukin 13)
Il2  (interleukin 2)
Klrc1  (killer cell lectin-like receptor subfamily C, member 1)
Ncr1  (natural cytotoxicity triggering receptor 1)
Ncr3-ps  (natural cytotoxicity triggering receptor 3, pseudogene)

Genes (Homo sapiens)
IFNG  (interferon gamma)
IL13  (interleukin 13)
IL2  (interleukin 2)
KIR2DS1  (killer cell immunoglobulin like receptor, two Ig domains and short cytoplasmic tail 1)
KLRC1  (killer cell lectin like receptor C1)
NCR1  (natural cytotoxicity triggering receptor 1)
NCR3  (natural cytotoxicity triggering receptor 3)


Additional Information