RGD Reference Report - [Single nucleotide polymorphism of interferon-gamma gene +874 T/A in patients with aplastic anemia]. - Rat Genome Database

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[Single nucleotide polymorphism of interferon-gamma gene +874 T/A in patients with aplastic anemia].

Authors: Chang, H  Zhang, JY  Meng, WT 
Citation: Chang H, etal., Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2008 Apr;16(2):325-7.
RGD ID: 10755710
Pubmed: PMID:18426658   (View Abstract at PubMed)

The aim of this study was to investigate whether the single nucleotide polymorphism (SNP) of interferon-gamma (IFN-gamma) +874 T/A correlates with aplastic anemia. Amplification refractory mutation system-polymerase chain reaction was used to amplify the polymorphism gene segment of IFN-gamma +874 A/T from 54 aplastic anemia patients and 51 healthy adults. The results showed that the frequency of IFN-gamma +874 TT genotype and T allele was significantly higher in patients with aplastic anemia than that in the healthy adults (42.6% vs 17.6%, chi2=13.780, p=0.01; 65.7% vs 39.2%; chi2=14.811, p<0.001). In conclusion, IFN-gamma +874 A/T gene polymorphism is correlated with the susceptibility of aplastic anemia, but not significantly correlated with the the severity of aplastic anemia.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
aplastic anemia susceptibilityIAGP 10755710DNA:polymorphism: : 874A>T(human)RGD 
aplastic anemia susceptibilityISOIFNG (Homo sapiens)10755710; 10755710DNA:polymorphism: : 874A>T(human)RGD 

Objects Annotated

Genes (Rattus norvegicus)
Ifng  (interferon gamma)

Genes (Mus musculus)
Ifng  (interferon gamma)

Genes (Homo sapiens)
IFNG  (interferon gamma)


Additional Information