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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2866
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Ifng
Name: interferon gamma
Acc ID: CHEBI:40618
Term: aminoguanidine
Definition: A one-carbon compound whose unique structure renders it capable of acting as a derivative of hydrazine, guanidine or formamide.
Chemical ID: MESH:C004479
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Ifngmultiple interactionsEXP 6480464CTDpimagedine inhibits the reaction [[IFNG protein co-treated with Lipopolysaccharides] results in increased abundance of Nitric Oxide]PMID:12911628
Ifngmultiple interactionsISOIFNG (Homo sapiens)6480464CTDpimagedine inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of APP mRNA]; pimagedine inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of APP protein]; pimagedine inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of BACE1 mRNA]; pimagedine inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of PSEN1 mRNA]; pimagedine inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of PSEN2 mRNA]; pimagedine inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased secretion of Nitric Oxide]PMID:28242320
Ifngmultiple interactionsISOIfng (Mus musculus)6480464CTDpimagedine inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased activity of NOS2 protein]; pimagedine inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased metabolism of Nitric Oxide]; pimagedine inhibits the reaction [[TNF protein co-treated with IFNG protein] results in increased chemical synthesis of Nitric Oxide]; pimagedine inhibits the reaction [Lipopolysaccharides promotes the reaction [IFNG protein results in increased abundance of Nitric Oxide]]PMID:11498278 PMID:12612912 PMID:12892526 PMID:7689037
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