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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2866
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Ifng
Name: interferon gamma
Acc ID: CHEBI:5674
Term: herbimycin
Definition: A 19-membered macrocyle incorporating a benzoquinone ring and a lactam functionality. It is an ansamycin antibiotic that induces apoptosis and displays antitumour effects.
Chemical ID: MESH:C020754
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Ifngmultiple interactionsEXP 6480464CTDherbimycin inhibits the reaction [[IFNG protein results in increased phosphorylation of and results in increased activity of STAT1 protein] which results in increased expression of NOS2 mRNA]PMID:10825233
Ifngmultiple interactionsISOIFNG (Homo sapiens)6480464CTDherbimycin inhibits the reaction [IFNG protein results in increased expression of ICAM1 mRNA]; herbimycin inhibits the reaction [IFNG protein results in increased expression of ICAM1 protein]PMID:12044887
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