RGD Reference Report - Children with recurrent otitis show defective IFN gamma-producing cells in adenoids. - Rat Genome Database

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Children with recurrent otitis show defective IFN gamma-producing cells in adenoids.

Authors: Avanzini, AM  Castellazzi, AM  Marconi, M  Valsecchi, C  Marseglia, A  Ciprandi, G  De Silvestri, A  Marseglia, GL 
Citation: Avanzini AM, etal., Pediatr Allergy Immunol. 2008 Sep;19(6):523-6. doi: 10.1111/j.1399-3038.2007.00682.x. Epub 2008 Feb 6.
RGD ID: 7987910
Pubmed: PMID:18266836   (View Abstract at PubMed)
DOI: DOI:10.1111/j.1399-3038.2007.00682.x   (Journal Full-text)

Infectious diseases are frequently observed in children and their recurrence represents a demanding challenge for the paediatrician. It has been hypothesized that a defective immune response may occur in these patients. The aim of the present study was to evaluate whether children presenting with recurrent otitis have a defective interferon (IFN)gamma production by the lymphocytes of peripheral blood and of adenoid tissue, in comparison with children without recurrent otitis. Our study group was represented by 58 children undergoing adenoidectomy for adenoidal hypertrophy. They were subdivided into two groups according to the recurrence of otitis (>or=3 per year) or not (<3 per year). Intracellular cytokine profile of lymphocyte subsets in adenoids and peripheral blood was evaluated by flow cytometry analysis. Children with recurrent otitis showed a significantly lower percentage of CD8+-producing IFN gamma cells in adenoids than children with <3 otitis per year (p = 0.003). The reduced capability of the adenoid cells to produce INF-gamma may induce a high susceptibility to the recurrence of otitis in children.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
otitis media  IEP 7987910associated with adenoidal hypertrophy and protein:decreased expression:T cell:RGD 
otitis media  ISOIFNG (Homo sapiens)7987910; 7987910associated with adenoidal hypertrophy and protein:decreased expression:T cell:RGD 

Objects Annotated

Genes (Rattus norvegicus)
Ifng  (interferon gamma)

Genes (Mus musculus)
Ifng  (interferon gamma)

Genes (Homo sapiens)
IFNG  (interferon gamma)


Additional Information