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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2866
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Ifng
Name: interferon gamma
Acc ID: CHEBI:34718
Term: 1-chloro-2,4-dinitrobenzene
Definition: A C-nitro compound that is chlorobenzene carrying a nitro substituent at each of the 2- and 4-positions.
Chemical ID: MESH:D004137
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Ifngincreases expressionEXP 6480464CTDDinitrochlorobenzene results in increased expression of IFNG mRNA; Dinitrochlorobenzene results in increased expression of IFNG proteinPMID:25449201
Ifngdecreases expressionISOIfng (Mus musculus)6480464CTDDinitrochlorobenzene results in decreased expression of IFNG mRNAPMID:28219650
Ifngincreases expressionISOIfng (Mus musculus)6480464CTDDinitrochlorobenzene results in increased expression of IFNG mRNA; Dinitrochlorobenzene results in increased expression of IFNG proteinPMID:10637130 PMID:11708898 PMID:12884401 PMID:15588918 PMID:18242016 PMID:18652873 PMID:19042193 PMID:19422874 PMID:21404309 PMID:23133493 PMID:23200891 PMID:23454147 PMID:29233007 PMID:30017638
Ifngincreases secretionISOIfng (Mus musculus)6480464CTDDinitrochlorobenzene results in increased secretion of IFNG proteinPMID:15588915 PMID:22245253
Ifngmultiple interactionsISOIfng (Mus musculus)6480464CTD4,4',4''-(4-propyl-((1)H)-pyrazole-1,3,5-triyl) tris-phenol inhibits the reaction [Dinitrochlorobenzene results in increased expression of IFNG protein]; [Antigens, Dermatophagoides co-treated with Dinitrochlorobenzene] results in increased expression of IFNG mRNA; [Dacarbazine co-treated with Dinitrochlorobenzene] results in increased expression of IFNG mRNA; Biological Products inhibits the reaction [Dinitrochlorobenzene results in increased expression of IFNG mRNA]; oleanolic acid 3-acetate inhibits the reaction [[Antigens, Dermatophagoides co-treated with Dinitrochlorobenzene] results in increased expression of IFNG mRNA]; Plant Extracts inhibits the reaction [Dinitrochlorobenzene results in increased expression of IFNG mRNA]; Plant Extracts inhibits the reaction [Dinitrochlorobenzene results in increased expression of IFNG protein]; Prednisolone inhibits the reaction [Dinitrochlorobenzene results in increased expression of IFNG mRNA]; Prednisolone inhibits the reaction [Dinitrochlorobenzene results in increased expression of IFNG protein]PMID:12202904 PMID:23133493 PMID:23200891 PMID:23454147 PMID:23499868 PMID:30017638
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