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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2866
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Ifng
Name: interferon gamma
Acc ID: CHEBI:5615
Term: halothane
Definition: A haloalkane comprising ethane having three flouro substituents at the 1-position as well as bromo- and chloro substituents at the 2-position.
Chemical ID: MESH:D006221
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Ifngincreases expressionEXP 6480464CTDHalothane results in increased expression of IFNG mRNAPMID:10422944
Ifngincreases expressionISOIfng (Mus musculus)6480464CTDHalothane results in increased expression of IFNG proteinPMID:21245496
Ifngincreases response to substanceISOIfng (Mus musculus)6480464CTDIFNG protein results in increased susceptibility to HalothanePMID:21245496
Ifngmultiple interactionsISOIfng (Mus musculus)6480464CTDPRF1 protein affects the reaction [Halothane results in increased expression of IFNG protein]; TLR4 protein affects the reaction [Halothane results in increased expression of IFNG protein]PMID:21245496
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