GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Ifng | decreases expression | ISO | Ifng (Mus musculus) | 6480464 | CTD | Zinc results in decreased expression of IFNG protein | PMID:14624943 | Ifng | decreases uptake | ISO | IFNG (Homo sapiens) | 6480464 | CTD | IFNG protein results in decreased uptake of Zinc | PMID:19306086 | Ifng | increases expression | ISO | IFNG (Homo sapiens) | 6480464 | CTD | Zinc results in increased expression of IFNG mRNA; Zinc results in increased expression of IFNG protein | PMID:16472982 PMID:18842795 | Ifng | increases secretion | ISO | IFNG (Homo sapiens) | 6480464 | CTD | Zinc results in increased secretion of IFNG protein | PMID:17150331 | Ifng | multiple interactions | ISO | IFNG (Homo sapiens) | 6480464 | CTD | [IFNG protein results in increased expression of SLC11A2 mRNA] which results in decreased uptake of Zinc; [Zinc co-treated with Lipopolysaccharides] results in increased expression of IFNG mRNA; N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine inhibits the reaction [Zinc results in increased secretion of IFNG protein]; Zinc deficiency affects the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of IFNG mRNA]; Zinc inhibits the reaction [[IFNG protein co-treated with TNF protein co-treated with N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine] results in increased cleavage of CDH1 protein]; Zinc inhibits the reaction [[IFNG protein co-treated with TNF protein co-treated with N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine] results in increased cleavage of CTNNB1 protein] | PMID:12812920 PMID:16434472 PMID:16844947 PMID:17150331 PMID:19306086 | Ifng | multiple interactions | ISO | Ifng (Mus musculus) | 6480464 | CTD | [IL1B protein co-treated with TNF protein co-treated with IFNG protein] affects the localization of Zinc; [zinc chloride results in increased abundance of Zinc] which results in decreased expression of IFNG mRNA; MT1 gene mutant form inhibits the reaction [[IL1B protein co-treated with TNF protein co-treated with IFNG protein] affects the localization of Zinc]; MT2 gene mutant form inhibits the reaction [[IL1B protein co-treated with TNF protein co-treated with IFNG protein] affects the localization of Zinc]; Nitric Oxide affects the reaction [[IL1B protein co-treated with TNF protein co-treated with IFNG protein] affects the localization of Zinc]; NOS2 gene mutant form inhibits the reaction [[IL1B protein co-treated with TNF protein co-treated with IFNG protein] affects the localization of Zinc] | PMID:14617770 PMID:31588059 | | ||||||||||||||||||||||
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