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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2866 Species: Rattus norvegicus RGD Object: Gene Symbol: Ifng Name: interferon gamma

Acc ID: CHEBI:16602 Term: trichloroethene Definition: A chloroethene that has formula C2HCl3. CasRN: 79-01-6 Chemical ID: MESH:D014241

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
multiple interactions	ISO	RGD:737488	6480464	CTD	[Trichloroethylene co-treated with 4-hydroxy-2-nonenal analog] results in increased expression of IFNG protein [Trichloroethylene co-treated with Malondialdehyde analog] results in increased expression of IFNG protein	PMID:18267128
multiple interactions	ISO	RGD:737488	6480464	CTD	[Trichloroethylene co-treated with Mercuric Chloride] results in increased expression of IFNG protein	PMID:21084432
decreases expression	ISO	RGD:737488	6480464	CTD	Trichloroethylene results in decreased expression of IFNG protein	PMID:18958647
increases expression	ISO	RGD:737488	6480464	CTD	Trichloroethylene results in increased expression of IFNG protein	PMID:19332086 PMID:18958721
increases expression	ISO	RGD:737488	6480464	CTD	Trichloroethylene results in increased expression of IFNG protein	PMID:18958721 PMID:19332086
decreases expression	ISO	RGD:737488	6480464	CTD	Trichloroethylene results in decreased expression of IFNG mRNA	PMID:22407948
decreases secretion	ISO	RGD:737488	6480464	CTD	Trichloroethylene results in decreased secretion of IFNG protein	PMID:22407948