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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2866
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Ifng
Name: interferon gamma
Acc ID: CHEBI:75142
Term: N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal
Definition: A tripeptide that is L-leucyl-L-leucyl-L-leucine in which the C-terminal carboxy group has been reduced to the corresponding aldehyde and the N-terminal amino group is protected as its benzyloxycarbonyl derivative.
Chemical ID: MESH:C072553
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Ifngmultiple interactionsEXP 6480464CTDbenzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [[IL1B protein co-treated with TNF protein co-treated with IFNG protein] results in increased expression of NOS2 mRNA]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [[TNF protein co-treated with IL1B protein co-treated with IFNG protein] results in increased expression of NOS2 mRNA]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Diclofenac promotes the reaction [[IL1B protein co-treated with TNF protein co-treated with IFNG protein] results in increased expression of NOS2 mRNA]]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Diclofenac promotes the reaction [[TNF protein co-treated with IL1B protein co-treated with IFNG protein] results in increased expression of NOS2 mRNA]]PMID:19393675 PMID:23395999
Ifngmultiple interactionsISOIfng (Mus musculus)6480464CTDbenzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [IFNG protein results in increased activity of CASP1 protein]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [IFNG protein results in increased activity of CASP6 protein]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [IFNG protein results in increased activity of CASP8 protein]; Quercetin inhibits the reaction [benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [IFNG protein results in increased activity of CASP1 protein]]; Quercetin inhibits the reaction [benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [IFNG protein results in increased activity of CASP6 protein]]; Quercetin inhibits the reaction [benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [IFNG protein results in increased activity of CASP8 protein]]PMID:15914627
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