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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2866
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Ifng
Name: interferon gamma
Acc ID: CHEBI:7596
Term: nitroprusside
Definition: An iron coordination entity that has formula C5FeN6O.
Chemical ID: MESH:D009599
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Ifngdecreases expressionISOIFNG (Homo sapiens)6480464CTDNitroprusside results in decreased expression of IFNG mRNAPMID:9201699
Ifngmultiple interactionsISOIFNG (Homo sapiens)6480464CTDIFNG protein inhibits the reaction [Nitroprusside results in increased expression of HMOX1 mRNA]; Nitroprusside inhibits the reaction [[IL1B protein co-treated with TNF protein co-treated with IFNG protein] results in increased expression of NOS2 mRNA]; Nitroprusside inhibits the reaction [[IL1B protein co-treated with TNF protein co-treated with IFNG protein] results in increased expression of NOS2 protein]PMID:10349844 PMID:11076874
Ifngmultiple interactionsISOIfng (Mus musculus)6480464CTD[Nitroprusside co-treated with TNF co-treated with IFNG] results in increased expression of CCL2 mRNA; [Nitroprusside co-treated with TNF co-treated with IFNG] results in increased expression of NFKBIA mRNA; [Nitroprusside co-treated with TNF co-treated with IFNG] results in increased expression of TLR2 mRNA; [Nitroprusside co-treated with TNF co-treated with IFNG] results in increased expression of TNF mRNAPMID:15153526
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