GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Ifng | decreases expression | EXP | | 6480464 | CTD | Ozone results in decreased expression of IFNG protein | PMID:30649513 | Ifng | multiple interactions | EXP | | 6480464 | CTD | [Ozone co-treated with Chlorine] affects the expression of IFNG mRNA; IFNG protein inhibits the reaction [Ozone results in increased expression of FN1 protein]; Ozone promotes the reaction [[IFNG protein results in increased expression of NOS2 protein] which results in increased abundance of Nitric Oxide]; Ozone promotes the reaction [IFNG protein results in increased abundance of Nitric Oxide]; Ozone promotes the reaction [IFNG protein results in increased expression of NOS2 mRNA]; Ozone promotes the reaction [IFNG protein results in increased expression of NOS2 protein]; Ozone promotes the reaction [Ovalbumin results in decreased expression of IFNG protein]; Ozone results in decreased expression of and results in decreased secretion of IFNG protein | PMID:18636392 PMID:24064130 PMID:29329427 PMID:7519435 PMID:8086166 | Ifng | decreases expression | ISO | Ifng (Mus musculus) | 6480464 | CTD | Ozone results in decreased expression of IFNG mRNA; Ozone results in decreased expression of IFNG protein | PMID:26342085 PMID:26673133 PMID:27380433 PMID:30090343 | Ifng | increases expression | ISO | IFNG (Homo sapiens) | 6480464 | CTD | Ozone results in increased expression of IFNG mRNA | PMID:23665308 | Ifng | increases expression | ISO | Ifng (Mus musculus) | 6480464 | CTD | Ozone results in increased expression of IFNG mRNA | PMID:27240593 | Ifng | multiple interactions | ISO | IFNG (Homo sapiens) | 6480464 | CTD | [Air Pollutants results in increased abundance of Ozone] which affects the methylation of IFNG gene; [Air Pollutants results in increased abundance of Ozone] which results in increased expression of IFNG mRNA; [Air Pollutants results in increased abundance of Ozone] which results in increased methylation of IFNG promoter; [Aripiprazole co-treated with Ozone] results in decreased expression of IFNG mRNA; [Vehicle Emissions co-treated with Ozone] results in decreased expression of IFNG protein | PMID:24385016 PMID:27058360 PMID:28046113 PMID:31476115 PMID:33603036 | Ifng | multiple interactions | ISO | Ifng (Mus musculus) | 6480464 | CTD | [Vehicle Emissions results in increased abundance of Ozone] which results in increased expression of IFNG mRNA; alpha-Tocopherol inhibits the reaction [Ozone promotes the reaction [Ovalbumin results in increased expression of IFNG protein]]; NFKB1 gene mutant form inhibits the reaction [Ozone promotes the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased activity of NOS2 protein]]; Ozone inhibits the reaction [[[Industrial Waste results in increased abundance of Water Pollutants] which co-treated with naphthenic acid] inhibits the reaction [[Lipopolysaccharides co-treated with IFNG] results in increased expression of NOS1 mRNA]]; Ozone inhibits the reaction [[[Industrial Waste results in increased abundance of Water Pollutants] which co-treated with naphthenic acid] results in decreased expression of IFNG mRNA]; Ozone inhibits the reaction [[Water Pollutants co-treated with naphthenic acid co-treated with Lipopolysaccharides co-treated with IFNG] results in decreased expression of IL1 mRNA]; Ozone inhibits the reaction [[Water Pollutants co-treated with naphthenic acid co-treated with Lipopolysaccharides co-treated with IFNG] results in increased expression of IL12 mRNA]; Ozone inhibits the reaction [[Water Pollutants co-treated with naphthenic acid co-treated with Lipopolysaccharides co-treated with IFNG] results in increased expression of TNF mRNA]; Ozone promotes the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased activity of NOS2 protein]; Ozone promotes the reaction [Ovalbumin results in increased expression of IFNG protein]; SB 239063 inhibits the reaction [Ozone promotes the reaction [Ovalbumin results in increased expression of IFNG protein]] | PMID:15064226 PMID:21355040 PMID:21940034 PMID:29284473 | | ||||||||||||||||||||||
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