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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2866
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Ifng
Name: interferon gamma
Acc ID: CHEBI:33216
Term: bisphenol A
Definition: A bisphenol that is 4,4'-methanediyldiphenol in which the methylene hydrogens are replaced by two methyl groups.
Chemical ID: MESH:C006780
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Ifngdecreases expressionEXP 6480464CTDbisphenol A results in decreased expression of IFNG mRNAPMID:18569609 PMID:19267065 PMID:25181051
Ifngmultiple interactionsEXP 6480464CTD[Phytochemicals co-treated with bisphenol A] results in decreased expression of IFNGPMID:20136622
Ifngincreases expressionISOIFNG (Homo sapiens)6480464CTDbisphenol A results in increased expression of IFNG mRNAPMID:19415476
Ifngincreases expressionISOIfng (Mus musculus)6480464CTDbisphenol A results in increased expression of IFNG mRNA; bisphenol A results in increased expression of IFNG proteinPMID:12510852 PMID:26942597 PMID:27145005 PMID:31551929 PMID:32012983
Ifngincreases secretionISOIFNG (Homo sapiens)6480464CTDbisphenol A results in increased secretion of IFNG proteinPMID:24349194
Ifngincreases secretionISOIfng (Mus musculus)6480464CTDbisphenol A results in increased secretion of IFNG proteinPMID:12711627
Ifngmultiple interactionsISOIFNG (Homo sapiens)6480464CTDbisphenol A results in decreased expression of and results in decreased secretion of IFNG protein; Drugs, Chinese Herbal inhibits the reaction [bisphenol A results in increased expression of IFNG mRNA]PMID:19415476 PMID:29192164
Ifngmultiple interactionsISOIfng (Mus musculus)6480464CTD[bisphenol A affects the susceptibility to [Lipopolysaccharides co-treated with IFNG protein]] which results in decreased expression of CD36 mRNA; [bisphenol A affects the susceptibility to [Lipopolysaccharides co-treated with IFNG protein]] which results in decreased expression of IL1B mRNA; [bisphenol A affects the susceptibility to [Lipopolysaccharides co-treated with IFNG protein]] which results in decreased expression of MARCO mRNA; [bisphenol A affects the susceptibility to [Lipopolysaccharides co-treated with IFNG protein]] which results in decreased expression of MMP9 mRNA; [bisphenol A affects the susceptibility to [Lipopolysaccharides co-treated with IFNG protein]] which results in decreased expression of NOS2 mRNA; [bisphenol A affects the susceptibility to [Lipopolysaccharides co-treated with IFNG protein]] which results in increased expression of IL6 mRNA; [bisphenol A affects the susceptibility to [Lipopolysaccharides co-treated with IFNG protein]] which results in increased expression of TNF mRNA; [bisphenol A affects the susceptibility to Ovalbumin] which affects the expression of IFNG protein; [bisphenol A co-treated with INS1 protein co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone] affects the expression of IFNG mRNA; bisphenol A affects the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of TNF mRNA]; bisphenol A inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of CD163 mRNA]; bisphenol A inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of CD36 mRNA]; bisphenol A inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of IL1B mRNA]; bisphenol A inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of MARCO mRNA]; bisphenol A inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of MMP9 mRNA]; bisphenol A inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of NOS2 mRNA]; bisphenol A promotes the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of and results in increased secretion of CCL2 protein]; bisphenol A promotes the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of and results in increased secretion of IL6 protein]; bisphenol A promotes the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of and results in increased secretion of TNF protein]; bisphenol A promotes the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of CCL2 mRNA]; bisphenol A promotes the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of IL6 mRNA]; bisphenol A promotes the reaction [Dietary Fats results in increased expression of IFNG mRNA]; bisphenol A promotes the reaction [Ovalbumin results in increased expression of and results in increased secretion of IFNG protein]; Decitabine inhibits the reaction [[bisphenol A affects the susceptibility to [Lipopolysaccharides co-treated with IFNG protein]] which results in decreased expression of CD36 mRNA]; Decitabine inhibits the reaction [[bisphenol A affects the susceptibility to [Lipopolysaccharides co-treated with IFNG protein]] which results in decreased expression of IL1B mRNA]; Decitabine inhibits the reaction [[bisphenol A affects the susceptibility to [Lipopolysaccharides co-treated with IFNG protein]] which results in decreased expression of MARCO mRNA]; Decitabine inhibits the reaction [[bisphenol A affects the susceptibility to [Lipopolysaccharides co-treated with IFNG protein]] which results in decreased expression of MMP9 mRNA]; Decitabine inhibits the reaction [[bisphenol A affects the susceptibility to [Lipopolysaccharides co-treated with IFNG protein]] which results in decreased expression of NOS2 mRNA]; Decitabine inhibits the reaction [[bisphenol A affects the susceptibility to [Lipopolysaccharides co-treated with IFNG protein]] which results in increased expression of IL6 mRNA]; Decitabine inhibits the reaction [[bisphenol A affects the susceptibility to [Lipopolysaccharides co-treated with IFNG protein]] which results in increased expression of TNF mRNA]; trichostatin A affects the reaction [bisphenol A affects the susceptibility to [Lipopolysaccharides co-treated with IFNG protein]]; trichostatin A inhibits the reaction [[bisphenol A affects the susceptibility to [Lipopolysaccharides co-treated with IFNG protein]] which results in decreased expression of CD36 mRNA]; trichostatin A inhibits the reaction [[bisphenol A affects the susceptibility to [Lipopolysaccharides co-treated with IFNG protein]] which results in decreased expression of MARCO mRNA]; trichostatin A inhibits the reaction [[bisphenol A affects the susceptibility to [Lipopolysaccharides co-treated with IFNG protein]] which results in increased expression of IL6 mRNA]; trichostatin A inhibits the reaction [[bisphenol A affects the susceptibility to [Lipopolysaccharides co-treated with IFNG protein]] which results in increased expression of TNF mRNA]; trichostatin A promotes the reaction [[bisphenol A affects the susceptibility to [Lipopolysaccharides co-treated with IFNG protein]] which results in decreased expression of NOS2 mRNA]PMID:29718165 PMID:29737898 PMID:33203037 PMID:33265944
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