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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2866
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Ifng
Name: interferon gamma
Acc ID: CHEBI:34674
Term: dextran sulfate
Definition: A polymer composed of repeating (1->6)-alpha-linked anhydroglucose sulfate units.
Chemical ID: MESH:D016264
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Ifngincreases expressionISOIfng (Mus musculus)6480464CTDDextran Sulfate results in increased expression of IFNG mRNA; Dextran Sulfate results in increased expression of IFNG proteinPMID:12105854 PMID:19940103 PMID:20637373 PMID:21359540 PMID:24038091 PMID:24384223 PMID:24548422 PMID:25231984 PMID:25472953 PMID:25837923 PMID:26973525 PMID:29672155 PMID:31737179 PMID:32272095
Ifngincreases secretionISOIfng (Mus musculus)6480464CTDDextran Sulfate results in increased secretion of IFNG proteinPMID:21858153
Ifngmultiple interactionsISOIfng (Mus musculus)6480464CTD2-(1'H-indole-3'-carbonyl)thiazole-4-carboxylic acid methyl ester inhibits the reaction [Dextran Sulfate results in increased expression of IFNG protein]; 7,14-dihydroxydocosa-4,8,10,12,16,19-hexaenoic acid inhibits the reaction [Dextran Sulfate results in increased expression of IFNG protein]; [Azoxymethane co-treated with Dextran Sulfate] results in decreased expression of IFNG protein; [Azoxymethane co-treated with Dextran Sulfate] results in increased expression of IFNG protein; [Dextran Sulfate affects the susceptibility to CD14 protein] which affects the expression of IFNG mRNA; [IL17A protein affects the susceptibility to Dextran Sulfate] which affects the expression of IFNG protein; [TNFRSF8 protein affects the susceptibility to Dextran Sulfate] which affects the secretion of IFNG protein; [TNFSF8 protein affects the susceptibility to Dextran Sulfate] which affects the secretion of IFNG protein; ADAM17 protein affects the reaction [Dextran Sulfate results in increased expression of IFNG protein]; celastrol inhibits the reaction [Dextran Sulfate results in increased expression of IFNG protein]; Coumarins inhibits the reaction [Dextran Sulfate results in increased expression of IFNG protein]; Erianin inhibits the reaction [Dextran Sulfate results in increased expression of IFNG protein]; geraniol inhibits the reaction [Dextran Sulfate results in increased expression of IFNG protein]; isoliquiritigenin inhibits the reaction [[Azoxymethane co-treated with Dextran Sulfate] results in decreased expression of IFNG protein]; Lipopolysaccharides affects the reaction [Dextran Sulfate results in increased expression of IFNG mRNA]; MIF protein affects the reaction [Dextran Sulfate results in increased expression of IFNG mRNA]; notoginsenoside R1 inhibits the reaction [Dextran Sulfate results in increased expression of IFNG mRNA]; PNU-282987 inhibits the reaction [Dextran Sulfate results in increased expression of IFNG protein]; Qingdai compound inhibits the reaction [Dextran Sulfate results in increased expression of IFNG mRNA]; Qingdai compound inhibits the reaction [Dextran Sulfate results in increased expression of IFNG protein]; Resveratrol inhibits the reaction [Dextran Sulfate results in increased expression of IFNG protein]; Sulfasalazine inhibits the reaction [Dextran Sulfate results in increased expression of IFNG protein]; Tetrachlorodibenzodioxin inhibits the reaction [Dextran Sulfate results in increased secretion of IFNG protein]PMID:12105854 PMID:19940103 PMID:21068411 PMID:21359540 PMID:21858153 PMID:24038091 PMID:24384223 PMID:24548422 PMID:25026504 PMID:25231984 PMID:25472953 PMID:25837923 PMID:26973525 PMID:28411859 PMID:29672155 PMID:31737179 PMID:32272095 PMID:34273909
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