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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2866 Species: Rattus norvegicus RGD Object: Gene Symbol: Ifng Name: interferon gamma

Acc ID: CHEBI:6682 Term: mangiferin Definition: A C-glycosyl compound consisting of 1,3,6,7-tetrahydroxyxanthen-9-one having a beta-D-glucosyl residue at the 6-position. CasRN: 4773-96-0 Chemical ID: MESH:C013592

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
multiple interactions	ISO	RGD:737488	6480464	CTD	mangiferin inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased abundance of Nitric Oxide]	PMID:15177305
multiple interactions	ISO	RGD:737488	6480464	CTD	mangiferin inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased abundance of Leukotriene B4]	PMID:15177302
multiple interactions	ISO	RGD:737488	6480464	CTD	mangiferin inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of CCL5 protein] mangiferin inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of CSF2 protein] mangiferin inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of CSF3 protein] mangiferin inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of IL6 protein] mangiferin inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of TNF protein]	PMID:15135318
multiple interactions	ISO	RGD:737488	6480464	CTD	mangiferin inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased abundance of Dinoprostone]	PMID:16716910 PMID:15177302
multiple interactions	ISO	RGD:737488	6480464	CTD	mangiferin inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of NOS2 mRNA] mangiferin inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of TNF mRNA] mangiferin promotes the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of TGFB1 mRNA]	PMID:12694877
multiple interactions	ISO	RGD:737488	6480464	CTD	mangiferin inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased secretion of TNF protein]	PMID:15222974
multiple interactions	EXP		6480464	CTD	mangiferin inhibits the reaction [[lipopolysaccharide, Escherichia coli 0111 B4 co-treated with IFNG protein] results in increased expression of NOS2 mRNA]	PMID:12694877
multiple interactions	ISO	RGD:737488	6480464	CTD	mangiferin inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased abundance of Dinoprostone]	PMID:15177302 PMID:16716910
multiple interactions	EXP		6480464	CTD	mangiferin inhibits the reaction [Galactosamine results in increased expression of IFNG mRNA]	PMID:22310181