GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2866
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Ifng
Name: interferon gamma
Acc ID: CHEBI:37537
Term: phorbol 13-acetate 12-myristate
Definition: A phorbol ester that has formula C36H56O8.
CasRN: 16561-29-8
Chemical ID: MESH:D013755
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
multiple interactionsISORGD:7374876480464CTDAspirin inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased secretion of IFNG protein]

PMID:15379866
multiple interactionsISORGD:7374876480464CTD[Calcimycin co-treated with Tetradecanoylphorbol Acetate] results in increased expression of IFNG protein

PMID:14994387
multiple interactionsISORGD:7374876480464CTDCyclosporine inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Calcimycin] results in increased expression of IFNG protein]

Tacrolimus inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Calcimycin] results in increased expression of IFNG protein]

PMID:1371491
multiple interactionsISORGD:7374876480464CTD[Lipopolysaccharides co-treated with Tetradecanoylphorbol Acetate] results in increased expression of IFNG protein

Sulfasalazine inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Lipopolysaccharides] results in increased expression of IFNG protein]

Spironolactone inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Lipopolysaccharides] results in increased expression of IFNG protein]

PMID:17051331
multiple interactionsISORGD:7374876480464CTDresveratrol inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of IFNG protein]

PMID:16154495
multiple interactionsISORGD:7374876480464CTDmonocyte locomotion inhibitory factor inhibits the reaction [Tetradecanoylphorbol Acetate results in increased secretion of IFNG protein]

PMID:16374615
multiple interactionsISORGD:7374876480464CTD[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of IFNG protein

PMID:17572062
PMID:15358692
PMID:16154495
multiple interactionsISORGD:7374876480464CTDTetradecanoylphorbol Acetate inhibits the reaction [IFNG protein promotes the reaction [decitabine results in increased expression of PLA2G2A protein]]

PMID:18953428
increases secretionISORGD:7374876480464CTDTetradecanoylphorbol Acetate results in increased secretion of IFNG protein

PMID:16374615
multiple interactionsISORGD:7374886480464CTD[Benzocaine co-treated with Ionomycin co-treated with Tetradecanoylphorbol Acetate] results in decreased expression of IFNG protein

[Cyclosporine co-treated with Ionomycin co-treated with Tetradecanoylphorbol Acetate] results in decreased expression of IFNG protein

[Pentamidine co-treated with Ionomycin co-treated with Tetradecanoylphorbol Acetate] results in decreased expression of IFNG protein

[Mercuric Chloride co-treated with Ionomycin co-treated with Tetradecanoylphorbol Acetate] results in decreased expression of IFNG protein

[tetrachloroplatinate co-treated with Ionomycin co-treated with Tetradecanoylphorbol Acetate] results in decreased expression of IFNG protein

[Thalidomide co-treated with Ionomycin co-treated with Tetradecanoylphorbol Acetate] results in decreased expression of IFNG protein

PMID:15588918
multiple interactionsISORGD:7374886480464CTDDimaprit inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of IFNG protein]

Famotidine inhibits the reaction [Dimaprit inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of IFNG protein]]

Histamine inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of IFNG mRNA]

Histamine inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of IFNG protein]

HRH2 protein affects the reaction [Histamine inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of IFNG protein]]

PMID:19277450
multiple interactionsISORGD:7374886480464CTDEstradiol affects the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of and results in increased secretion of IFNG protein]

resveratrol affects the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of and results in increased secretion of IFNG protein]

PMID:16716911
multiple interactionsEXP 6480464CTDbenzamide inhibits the reaction [[Ionomycin co-treated with Tetradecanoylphorbol Acetate] results in increased expression of IFNG mRNA]

phenanthridone inhibits the reaction [[Ionomycin co-treated with Tetradecanoylphorbol Acetate] results in increased expression of IFNG mRNA]

PMID:12411406
multiple interactionsISORGD:7374876480464CTD[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of IFNG protein

PMID:16154495
PMID:17572062
PMID:15358692
multiple interactionsISORGD:7374886480464CTDTetradecanoylphorbol Acetate promotes the reaction [[TNF protein co-treated with IFNG protein co-treated with IL1B protein] results in increased abundance of Dinoprostone]

PMID:14623498
multiple interactionsISORGD:7374886480464CTDAm 80 inhibits the reaction [[Ionomycin co-treated with Tetradecanoylphorbol Acetate] results in increased expression of IFNG protein]

tamibarotene inhibits the reaction [[Ionomycin co-treated with Tetradecanoylphorbol Acetate] results in increased expression of IFNG protein]

PMID:22077062
multiple interactionsISORGD:7374876480464CTD[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of IFNG protein

PMID:15358692
PMID:17572062
PMID:16154495
multiple interactionsISORGD:7374876480464CTD[Ionomycin co-treated with Tetradecanoylphorbol Acetate] results in increased activity of IFNG promoter

nickel chloride inhibits the reaction [[Ionomycin co-treated with Tetradecanoylphorbol Acetate] results in increased activity of IFNG promoter]

PMID:21569788
multiple interactionsISORGD:7374876480464CTD[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of IFNG protein

PMID:15358692
PMID:16154495
PMID:17572062
multiple interactionsISORGD:7374876480464CTD[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of IFNG mRNA

Zinc deficiency affects the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of IFNG mRNA]

PMID:12812920
multiple interactionsISORGD:7374876480464CTD[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of IFNG protein

PMID:12812920
PMID:15358692
PMID:16154495
PMID:17572062
increases expressionISORGD:7374876480464CTDTetradecanoylphorbol Acetate results in increased expression of IFNG mRNA

PMID:18541274
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