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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2866
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Ifng
Name: interferon gamma
Acc ID: CHEBI:4917
Term: eugenol
Definition: A phenylpropanoid formally derived from guaiacol with an allyl chain substituted para to the hydroxy group. It is a major component of clove essential oil, and exhibits antibacterial, analgesic and antioxidant properties. It has been widely used in dentistry to treat toothache and pulpitis.
Chemical ID: MESH:D005054
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Ifngincreases secretionISOIfng (Mus musculus)6480464CTDEugenol results in increased secretion of IFNG proteinPMID:22245253
Ifngmultiple interactionsISOIfng (Mus musculus)6480464CTD[Methoxychlor co-treated with Eugenol] results in increased expression of IFNG protein; [Parathion co-treated with Eugenol] results in increased expression of IFNG proteinPMID:20920556
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