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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2866
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Ifng
Name: interferon gamma
Acc ID: CHEBI:50102
Term: N-methyl-N-nitrosourea
Definition: A member of the class of N-nitrosoureas that is urea in which one of the nitrogens is substituted by methyl and nitroso groups.
Chemical ID: MESH:D008770
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Ifngmultiple interactionsEXP 6480464CTD2-Acetylaminofluorene inhibits the reaction [[Diethylnitrosamine co-treated with Methylnitrosourea co-treated with Butylhydroxybutylnitrosamine co-treated with diisopropanolnitrosamine co-treated with 1,2-Dimethylhydrazine] results in decreased expression of IFNG protein]; [Diethylnitrosamine co-treated with Methylnitrosourea co-treated with Butylhydroxybutylnitrosamine co-treated with diisopropanolnitrosamine co-treated with 1,2-Dimethylhydrazine] results in decreased expression of IFNG proteinPMID:14736494
Ifngdecreases response to substanceISOIfng (Mus musculus)6480464CTDIFNG protein results in decreased susceptibility to MethylnitrosoureaPMID:15240709 PMID:16080182
Ifngmultiple interactionsISOIfng (Mus musculus)6480464CTDIFNG protein inhibits the reaction [Methylnitrosourea results in decreased expression of IL10 protein]; IFNG protein inhibits the reaction [Methylnitrosourea results in increased expression of CCL2 protein]; IFNG protein inhibits the reaction [Methylnitrosourea results in increased expression of CSF2 protein]; IFNG protein inhibits the reaction [Methylnitrosourea results in increased expression of IL2 protein]; IFNG protein inhibits the reaction [Methylnitrosourea results in increased expression of IL4 protein]; IFNG protein inhibits the reaction [Methylnitrosourea results in increased expression of LEP protein]; IFNG protein inhibits the reaction [Methylnitrosourea results in increased expression of THPO protein]; IFNG protein inhibits the reaction [Methylnitrosourea results in increased expression of TNF protein]; IFNG protein inhibits the reaction [Methylnitrosourea results in increased expression of VEGFA protein]PMID:16822543
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