Gene:	Fos ( Rattus norvegicus ) FBJ osteosarcoma oncogene
Description:	an immediate early gene encoding a nuclear protein involved in signal transduction
Synonyms:	v-fos FBJ murine osteosarcoma viral oncogene homolog; cellular oncogene fos; c-fos oncogene; c-fos; FBJ murine osteosarcoma viral oncogene homolog; FBJ murine osteosarcoma viral (v-fos) oncogene homolog;
ArrayIDs:	X06769cds_g_at; 5709826; 6346538; 1375043_at; rc_AI072183_at; X06769cds_at; rc_AI176185_at; GE16552; X03347cds_g_at; 5644370; GE22096; 5865157; A_42_P552092; X03347cds_at; 5917432; GE18981; 5941994; A_44_P495480; 5738378;  (details...)
Gene Type:	protein-coding
Additional Data
Homologs
Homo sapiens: FOS     See the Human gene in context in:     UCSC     NCBI MapViewer
Mus musculus: Fos     See the Mouse gene in context in:     UCSC     NCBI MapViewer
Comparative Map Data Species Symbol Map Name Chr. Position Rattus norvegicus Fos Rat Celera Assembly 6 102942483 - 102945875     RGSC genome assembly v3.4 6 109559154 - 109562546     Cytogenetic 6 q31     genome assembly 3.1 6 109562609 - 109566002 Mus musculus Fos Mouse genome assembly build 36.1 12 86814851 - 86818219     Cytogenetic 12 12 D2 Homo sapiens FOS human genome assembly 14 74815283 - 74818666     Human genome assembly build 36.2 14 74815284 - 74818666     Cytogenetic 14 q24.3   View comparative maps:      NCBI MapViewer
Genome
View:
Browsers:	Select a browser to viewGene (GBrowse)Gene and SNPs (GBrowse)UCSCVCMAPEnsemblNCBIECRVISTAVISTA+UCSC
Annotation
Molecular Function	Note Reference may play a role in androgen regulated apoptosis 70259 Gene Ontology transcription factor activity,  R-SMAD binding,  DNA binding ...  (details...)
Biological Process	Note Reference increases the intracellular calcium ion levels which helps in the degradation of phosphatidyl inositol and activation of protein kinase C 70259 increases transcription associated with cell death in prostate regression 70259 Gene Ontology response to toxin,  response to gravity,  response to cytokine stimulus ...  (details...)
Cellular Component	Gene Ontology transcription factor complex,  nucleus,  nucleolus ...  (details...)
Disease	Ontology Osteopetrosis,  Heart Failure, Congestive,  Tongue Neoplasms ...  (details...)
Phenotype	Ontology osteoporosis,  postnatal growth retardation,  impaired hematopoiesis ...  (details...)
Regulation	Note Reference expression is induced in response to airpuff startle in hypothalamus, thalamus, midbrain, pons and medulla 1358971
Physical interaction	Note Reference forms heterodimeric complexes with proteins of the Jun family which then bind to the AP-1 gene promoter site to regulate gene expression 1302797
External Links
Databases	DATABASE ID SOURCE SMART: BRLZ IPI PROSITE: BZIP_BASIC IPI PROSITE: BZIP IPI UNIPARC: UPI000012AB6E IPI KEGG Report: rno:314322 ENTREZGENE HomoloGene Group ID: 3844 ENTREZGENE Germonline: 2626 Germonline: 735054 Pfam: bZIP_1 IPI KEGG Pathway: 04010 ENTREZGENE KEGG Pathway: 04620 ENTREZGENE KEGG Pathway: 04660 ENTREZGENE KEGG Pathway: 05200 ENTREZGENE KEGG Pathway: 05210 ENTREZGENE KEGG Pathway: 04662 ENTREZGENE InterPro: bZIP_1. IPI InterPro: TF_bZIP. IPI InterPro: Leuzip_Fos. IPI IPI: IPI00567106 IPI Ensembl Protein: ENSRNOP00000010712 IPI Entrez Gene: Fos ENTREZGENE UniProt: Q5U873_RAT IPI UniProt: Q63752_RAT IPI UniProt: FOS_RAT IPI UniProt: Q5G6W2_RAT IPI UniProt: Q5G6W3_RAT IPI UniProt: Q5U7E3_RAT IPI UniProt: Q5U874_RAT IPI UniProt: Q9EQC2_RAT IPI UniProt: Q5U875_RAT IPI Ensembl Genes: ENSRNOG00000008015 IPI RatMap: 33950 ENTREZGENE PRINTS: LEUZIPPRFOS. IPI
Sequences	Nucleotide: AY780202 Get FASTA Search GEO Profiles Nucleotide: DQ089699 Get FASTA Search GEO Profiles Nucleotide: CH473982 Get FASTA Search GEO Profiles Nucleotide: AY828999 Get FASTA Search GEO Profiles Nucleotide: AY828998 Get FASTA Search GEO Profiles Nucleotide: AY786174 Get FASTA Search GEO Profiles Nucleotide: AY780203 Get FASTA Search GEO Profiles Nucleotide: M34001 Get FASTA Search GEO Profiles Nucleotide: AY780201 Get FASTA Search GEO Profiles Nucleotide: AF277645 Get FASTA Search GEO Profiles Nucleotide: AF126534 Get FASTA Search GEO Profiles Nucleotide: NM_022197 Get FASTA Search GEO Profiles Nucleotide: X06769 Get FASTA Search GEO Profiles Nucleotide: U02631 Get FASTA Search GEO Profiles (View all 14 Nucleotide Accessions) Protein: AAA42348 Get FASTA Protein: CAA29937 Get FASTA Protein: P12841 Get FASTA Protein: Q5G6W2 Get FASTA Protein: Q5G6W3 Get FASTA Protein: AAZ13764 Get FASTA Protein: Q5U873 Get FASTA Protein: Q5U874 Get FASTA Protein: Q5U875 Get FASTA Protein: Q63752 Get FASTA Protein: Q9EQC2 Get FASTA Protein: NP_071533 Get FASTA Protein: AAG47951 Get FASTA Protein: AAV33852 Get FASTA Protein: AAV33853 Get FASTA Protein: AAV33854 Get FASTA Protein: AAV41063 Get FASTA Protein: AAW65541 Get FASTA Protein: AAW65542 Get FASTA Protein: EDL81573 Get FASTA Protein: EDL81574 Get FASTA Protein: EDL81575 Get FASTA Protein: Q5U7E3 Get FASTA (View all 23 Protein Accessions)
Clusters	UniGene: 103750
References
Curated References	46 references in RGD related to Fos
Other References	193 other references at PubMed related to Fos
Database Information
RGD ID	2626
History	Date Current Symbol Current Name Previous Symbol Previous name Status Description Reference 15-FEB-08: Fos FBJ osteosarcoma oncogene Fos FBJ murine osteosarcoma viral oncogene homolog APPROVED Nomenclature updated to reflect human and mouse nomenclature 1299863 28-FEB-05: Fos FBJ murine osteosarcoma viral oncogene homolog c-fos c-fos oncogene APPROVED Data Merged 737654 20-JAN-05: Fos FBJ murine osteosarcoma viral oncogene homolog v-fos FBJ murine osteosarcoma viral oncogene homolog APPROVED Name updated 1299863 10-JUN-02: Fos v-fos FBJ murine osteosarcoma viral oncogene homolog PROVISIONAL Name updated 70585