Fos (Fos proto-oncogene, AP-1 transcription factor subunit) - Rat Genome Database

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Gene: Fos (Fos proto-oncogene, AP-1 transcription factor subunit) Rattus norvegicus
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Symbol: Fos
Name: Fos proto-oncogene, AP-1 transcription factor subunit
RGD ID: 2626
Description: Enables DNA binding activity; DNA-binding transcription factor activity; and promoter-specific chromatin binding activity. Involved in several processes, including cellular response to epidermal growth factor stimulus; learning or memory; and nervous system development. Located in endoplasmic reticulum; nuclear matrix; and nucleoplasm. Used to study alcohol dependence; alcohol use disorder; gastric ulcer; and morphine dependence. Biomarker of several diseases, including alcohol dependence; alcohol use disorder; artery disease (multiple); brain disease (multiple); and drug dependence (multiple). Orthologous to human FOS (Fos proto-oncogene, AP-1 transcription factor subunit); PARTICIPATES IN endothelin signaling pathway; fibroblast growth factor signaling pathway; forkhead class A signaling pathway; INTERACTS WITH (+)-pilocarpine; (+)-taxifolin; (+)-Tetrandrine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: c-fos; c-fos oncogene; cellular oncogene fos; FBJ murine osteosarcoma viral (v-fos) oncogene homolog; FBJ murine osteosarcoma viral oncogene homolog; FBJ osteosarcoma oncogene; proto-oncogene c-FOS; proto-oncogene cFOS; v-fos FBJ murine osteosarcoma viral oncogene homolog
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr86110,852,188 - 110,855,054 (+)NCBIGRCr8
mRatBN7.26105,121,170 - 105,124,036 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl6105,121,170 - 105,124,036 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx6105,290,640 - 105,293,508 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.06105,589,531 - 105,592,399 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.06104,959,176 - 104,962,044 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.06109,300,433 - 109,303,299 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl6109,300,433 - 109,303,299 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.06116,249,742 - 116,252,608 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.46109,559,135 - 109,562,001 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.16109,562,609 - 109,566,002 (+)NCBI
Celera6102,942,464 - 102,945,330 (+)NCBICelera
Cytogenetic Map6q31NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
Aberrant Crypt Foci  (IDA,IEP)
acute myocardial infarction  (IEP)
alcohol dependence  (IDA,IEP)
alcohol use disorder  (IDA,IEP,ISO)
alcohol withdrawal syndrome  (IEP)
Alcohol-Related Disorders  (IEP)
Alcoholic Intoxication  (IEP)
amphetamine abuse  (IEP,ISO)
amyotrophic lateral sclerosis type 1  (ISO)
Animal Disease Models  (ISO)
anxiety disorder  (ISO)
autosomal dominant polycystic kidney disease  (ISO)
Binge Drinking  (IEP)
Brain Hypoxia-Ischemia  (IEP)
Brain Injuries  (ISO)
Breast Neoplasms  (ISO)
cervical squamous cell carcinoma  (ISO)
cocaine abuse  (ISO)
cocaine dependence  (IEP)
Cocaine-Related Disorders  (IEP,ISO)
Colonic Neoplasms  (ISO)
colorectal adenocarcinoma  (ISO)
colorectal adenoma  (ISO)
Colorectal Neoplasms  (ISO)
congenital hypothyroidism  (IEP)
congestive heart failure  (IEP)
degenerative disc disease  (IEP)
depressive disorder  (IEP)
endometriosis  (ISO)
epilepsy  (IEP,ISO)
Experimental Arthritis  (IEP)
Experimental Liver Cirrhosis  (ISO)
extrahepatic cholestasis  (ISO)
Fetal Growth Retardation  (IEP)
Fibrous Dysplasia of Bone  (ISO)
functional diarrhea  (IEP)
gastric ulcer  (IEP,IMP)
glomerulonephritis  (IEP)
Heat Stroke  (ISO)
Hematuria  (IDA,IEP)
hemolytic-uremic syndrome  (ISO)
Hemorrhage  (ISO)
hepatocellular carcinoma  (ISO)
Hyperalgesia  (IEP,ISO)
Hyperkinesis  (ISO)
hypertension  (IEP,ISO)
hypospadias  (IEP)
Inhalant Abuse  (IEP)
intellectual disability  (ISO)
irritable bowel syndrome  (IEP)
juvenile rheumatoid arthritis  (ISO)
Kidney Reperfusion Injury  (ISO)
Lung Neoplasms  (ISO)
middle cerebral artery infarction  (ISO)
migraine  (IEP)
morphine dependence  (IDA,IEP,IMP)
morphine withdrawal syndrome  (IEP)
myocardial infarction  (IEP)
Neoplastic Cell Transformation  (ISO)
nervous system disease  (ISO)
nicotine dependence  (IEP,ISO)
Nociceptive Pain  (IEP)
obesity  (ISO)
ovarian carcinoma  (ISO)
Pick's disease  (ISO)
post-traumatic stress disorder  (ISO)
rectal benign neoplasm  (ISO)
Reperfusion Injury  (IEP,ISO)
sleeping sickness  (IEP)
status epilepticus  (ISO)
temporal lobe epilepsy  (IEP)
Tendon Injuries  (IDA)
Tongue Neoplasms  (IEP)
tongue squamous cell carcinoma  (ISO)
toxic encephalopathy  (ISO)
trigeminal neuralgia  (ISO)
Ventilator-Induced Lung Injury  (IEP)
Wernicke encephalopathy  (IEP)
withdrawal disorder  (ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-catechin  (ISO)
(+)-pilocarpine  (EXP)
(+)-Pimaric acid  (ISO)
(+)-taxifolin  (EXP)
(+)-Tetrandrine  (EXP)
(-)-alpha-phellandrene  (ISO)
(-)-anisomycin  (ISO)
(-)-citrinin  (ISO)
(-)-demecolcine  (ISO)
(-)-ephedrine  (ISO)
(-)-epigallocatechin 3-gallate  (ISO)
(-)-selegiline  (ISO)
(20R)-protopanaxadiol  (ISO)
(20S)-ginsenoside Rh1  (ISO)
(E)-roxithromycin  (ISO)
(R)-lipoic acid  (EXP)
(R)-noradrenaline  (EXP,ISO)
(S)-amphetamine  (EXP,ISO)
(S)-colchicine  (EXP)
(S)-naringenin  (ISO)
(S)-nicotine  (EXP,ISO)
(Z)-ligustilide  (ISO)
1,1,1-trichloro-2,2-bis(4-hydroxyphenyl)ethane  (ISO)
1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane  (EXP,ISO)
1,2,4,5-tetrachlorobenzene  (EXP)
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (ISO)
1,2-naphthoquinone  (ISO)
1,4-dichlorobenzene  (EXP)
1-(3-chlorophenyl)piperazine  (EXP,ISO)
1-(5-isoquinolinesulfonyl)-2-methylpiperazine  (EXP,ISO)
1-chloro-2,4-dinitrobenzene  (ISO)
1-naphthyl isothiocyanate  (EXP,ISO)
1-nitropyrene  (ISO)
15-deoxy-Delta(12,14)-prostaglandin J2  (EXP,ISO)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (EXP,ISO)
17beta-estradiol 3-benzoate  (EXP,ISO)
17beta-hydroxy-5alpha-androstan-3-one  (ISO)
1D-myo-inositol 1,4,5-trisphosphate  (EXP)
2,2',4,4',5,5'-hexachlorobiphenyl  (EXP,ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3-Dioxo-6-nitro-7-sulfamoylbenzo(f)quinoxaline  (EXP)
2,4,6-trinitrobenzenesulfonic acid  (EXP)
2,4,6-trinitrotoluene  (ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
2,4-dinitrotoluene  (ISO)
2,6-dinitrotoluene  (ISO)
2-(3,4-dimethoxyphenyl)-5-\{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino\}-2-(propan-2-yl)pentanenitrile  (ISO)
2-(4-iodo-2,5-dimethoxyphenyl)-1-methylethylamine  (EXP,ISO)
2-acetamidofluorene  (EXP)
2-amino-2-deoxy-D-glucopyranose  (ISO)
2-amino-3-hydroxypyridine  (ISO)
2-aminopurine  (ISO)
2-butoxyethanol  (ISO)
2-hydroxypropanoic acid  (ISO)
2-methyl-6-(phenylethynyl)pyridine  (EXP)
2-nitrotoluene  (EXP)
2-tert-butylhydroquinone  (EXP,ISO)
2-trans,6-trans-farnesyl diphosphate  (ISO)
22-Hydroxycholesterol  (ISO)
3',5'-cyclic AMP  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (ISO)
3,4-methylenedioxymethamphetamine  (EXP,ISO)
3,5-dichloro-N-[[(2S)-1-ethyl-2-pyrrolidinyl]methyl]-2-hydroxy-6-methoxybenzamide  (EXP)
3-\{1-[3-(dimethylamino)propyl]-1H-indol-3-yl\}-4-(1H-indol-3-yl)-1H-pyrrole-2,5-dione  (EXP,ISO)
3-iodobenzyl-5'-N-methylcarboxamidoadenosine  (EXP)
3-Methoxynobiletin  (ISO)
3-phenylprop-2-enal  (ISO)
4,4'-diaminodiphenylmethane  (EXP)
4,4'-sulfonyldiphenol  (ISO)
4,5,6,7-TETRABROMOBENZOTRIAZOLE  (ISO)
4-(N-nitrosomethylamino)-1-(3-pyridyl)butan-1-one  (ISO)
4-[1-hydroxy-2-[4-(phenylmethyl)-1-piperidinyl]propyl]phenol  (EXP,ISO)
4-amino-5-chloro-N-[1-[3-(4-fluorophenoxy)propyl]-3-methoxy-4-piperidinyl]-2-methoxybenzamide  (ISO)
4-DAMP(1+)  (ISO)
4-hydroxynon-2-enal  (EXP,ISO)
4-nitrophenol  (ISO)
4-nonylphenol  (ISO)
4-octylphenol  (ISO)
4-tert-Octylphenol  (EXP)
5,6,7-trimethoxyflavone  (ISO)
5-(2-methylpiperazine-1-sulfonyl)isoquinoline  (EXP,ISO)
5-aza-2'-deoxycytidine  (EXP,ISO)
5-chloro-7-iodoquinolin-8-ol  (ISO)
5-fluorouracil  (ISO)
6-Cyano-7-nitroquinoxaline-2,3-dione  (EXP)
6-propyl-2-thiouracil  (EXP)
7,12-dimethyltetraphene  (ISO)
8-(3-chlorostyryl)caffeine  (EXP)
8-OH-DPAT  (EXP,ISO)
9-Methoxycamptothecin  (ISO)
acebutolol  (ISO)
acephate  (EXP)
acetaldehyde  (EXP,ISO)
acetylsalicylic acid  (EXP,ISO)
acrivastine  (ISO)
acrolein  (EXP,ISO)
acrylamide  (EXP,ISO)
acrylonitrile  (ISO)
actinomycin D  (EXP,ISO)
afimoxifene  (ISO)
aflatoxin B1  (EXP,ISO)
AH23848  (ISO)
alcohol  (EXP,ISO)
aldehydo-D-glucosamine  (ISO)
aldehydo-D-glucose  (EXP,ISO)
alfuzosin  (EXP)
Alisol B  (ISO)
all-trans-retinoic acid  (EXP,ISO)
allopurinol  (ISO)
alpha-hexachlorocyclohexane  (EXP)
alpha-naphthoflavone  (ISO)
alpha-phellandrene  (ISO)
alpha-pinene  (ISO)
aluminium atom  (ISO)
aluminium oxide  (ISO)
aluminium(0)  (ISO)
AM-251  (ISO)
amiloride  (ISO)
amiodarone  (ISO)
ammonium chloride  (EXP)
ammonium hydroxide  (EXP)
amphetamine  (EXP,ISO)
anandamide  (EXP)
andrographolide  (ISO)
aniline  (EXP)
anthra[1,9-cd]pyrazol-6(2H)-one  (EXP,ISO)
antimonite  (ISO)
antimycin A  (ISO)
antirheumatic drug  (ISO)
apigenin  (ISO)
apomorphine  (EXP)
arachidonic acid  (ISO)
arecoline  (ISO)
aristolochic acid A  (ISO)
Aroclor 1254  (EXP,ISO)
arsane  (ISO)
arsenic acid  (EXP)
arsenic atom  (ISO)
arsenite(3-)  (EXP,ISO)
arsenous acid  (EXP,ISO)
asbestos  (ISO)
astressin  (EXP)
ATP  (EXP,ISO)
atrazine  (EXP,ISO)
atropine  (EXP,ISO)
avobenzone  (ISO)
Azaspiracid  (ISO)
azathioprine  (ISO)
azithromycin  (ISO)
baclofen  (EXP,ISO)
BAPTA  (EXP)
bathocuproine disulfonic acid  (ISO)
Bay-K-8644  (EXP,ISO)
bazedoxifene  (ISO)
beclomethasone  (ISO)
benazepril  (EXP)
benzene  (ISO)
benzo[a]pyrene  (EXP,ISO)
benzo[a]pyrene diol epoxide I  (ISO)
Benzo[k]fluoranthene  (ISO)
benzofurans  (ISO)
benzophenone  (ISO)
Benzoyl peroxide  (ISO)
Bergenin  (EXP)
beryllium difluoride  (ISO)
beryllium sulfate  (ISO)
beta-D-glucosamine  (ISO)
beta-lapachone  (ISO)
beta-naphthoflavone  (EXP,ISO)
bezafibrate  (ISO)
bicalutamide  (ISO)
bilobalide  (EXP)
bis(2-chloroethyl) sulfide  (ISO)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisphenol A  (EXP,ISO)
Bisphenol B  (ISO)
bisphenol F  (EXP,ISO)
bleomycin A2  (ISO)
bromochloroacetic acid  (EXP)
bucladesine  (ISO)
bufalin  (ISO)
bupropion  (ISO)
buta-1,3-diene  (ISO)
butan-1-ol  (EXP,ISO)
butanal  (ISO)
butylated hydroxyanisole  (ISO)
butyric acid  (EXP)
C.I. Natural Red 20  (ISO)
C60 fullerene  (EXP)
cadmium atom  (EXP,ISO)
cadmium dichloride  (EXP,ISO)
cadmium sulfate  (ISO)
caffeine  (ISO)
Calcimycin  (EXP,ISO)
calcitriol  (ISO)
Calphostin C  (EXP)
calyculin a  (ISO)
camostat  (ISO)
candesartan  (EXP)
cannabidiol  (EXP,ISO)
cannabidiolic acid  (ISO)
Cannabinol  (ISO)
capsaicin  (EXP,ISO)
capsazepine  (EXP)
captan  (ISO)
carbachol  (EXP,ISO)
carbamazepine  (EXP,ISO)
carbaryl  (ISO)
carbon nanotube  (ISO)
carnosine  (EXP)
carrageenan  (EXP)
cefaloridine  (EXP)
celecoxib  (EXP,ISO)
CGS-21680  (EXP)
chenodeoxycholic acid  (ISO)
chloral hydrate  (EXP)
Chloralose  (EXP)
chlormequat chloride  (EXP)
chloroform  (ISO)
chloropicrin  (ISO)
chloroprene  (ISO)
chlorpromazine  (ISO)
chlorpropamide  (ISO)
chlorpyrifos  (EXP,ISO)
choline  (ISO)
chromium atom  (ISO)
chromium(6+)  (EXP,ISO)
chrysene  (ISO)
chrysin  (ISO)
ciglitazone  (EXP,ISO)
ciguatoxin CTX1B  (ISO)
Cinobufagin  (ISO)
ciprofibrate  (ISO)
cisapride  (ISO)
cisplatin  (EXP,ISO)
clarithromycin  (ISO)
clofibrate  (ISO)
clonidine  (ISO)
clonidine (amino form)  (ISO)
clonidine (imino form)  (ISO)
clotrimazole  (ISO)
clozapine  (EXP,ISO)
cobalt atom  (EXP,ISO)
cobalt dichloride  (EXP,ISO)
cobalt(2+) sulfate  (ISO)
cocaine  (EXP,ISO)
colforsin daropate hydrochloride  (EXP)
copper atom  (EXP,ISO)
copper(0)  (EXP,ISO)
copper(II) chloride  (ISO)
copper(II) sulfate  (ISO)
corilagin  (ISO)
corticosterone  (ISO)
coumestrol  (ISO)
crocidolite asbestos  (EXP,ISO)
CU-O LINKAGE  (ISO)
curcumin  (EXP,ISO)
cyanamide  (EXP)
cycloheximide  (EXP,ISO)
cyclophosphamide  (EXP,ISO)
cyclosporin A  (ISO)
cylindrospermopsin  (ISO)
cypermethrin  (EXP,ISO)
D-cycloserine  (EXP)
D-glucose  (EXP,ISO)
D-mannitol  (EXP)
daidzein  (ISO)
daidzein 7-O-beta-D-glucoside  (ISO)
DDE  (ISO)
DDT  (EXP,ISO)
decabromodiphenyl ether  (EXP)
deguelin  (ISO)
dehydroepiandrosterone  (ISO)
dehydroepiandrosterone sulfate  (ISO)
delta-hexachlorocyclohexane  (EXP)
deoxynivalenol  (ISO)
desipramine  (EXP)
Destruxin B  (ISO)
devazepide  (EXP)
dexamethasone  (EXP,ISO)
dextran sulfate  (ISO)
dextromethorphan  (EXP,ISO)
Diallyl sulfide  (EXP)
diallyl trisulfide  (ISO)
diamminedichloroplatinum  (EXP,ISO)
diarsenic trioxide  (EXP,ISO)
diarylheptanoid  (ISO)
diazepam  (EXP,ISO)
dibenziodolium  (ISO)
Dibutyl phosphate  (ISO)
dibutyl phthalate  (EXP,ISO)
dichlorine  (EXP)
dichloroacetic acid  (ISO)
dichloromethane  (ISO)
diclofenac  (ISO)
dieckol  (ISO)
dieldrin  (ISO)
diethyl maleate  (ISO)
diethylstilbestrol  (EXP,ISO)
diflunisal  (ISO)
diiodine  (EXP)
diisopropyl fluorophosphate  (EXP)
Dimaprit  (ISO)
dimemorfan  (EXP,ISO)
dimethyl sulfoxide  (EXP)
dimethylarsinic acid  (ISO)
dimethylarsinous acid  (ISO)
dimethyldithiocarbamate  (EXP)
dinophysistoxin 1  (ISO)
dioxygen  (EXP,ISO)
diphenylcyclopropenone  (ISO)
dipotassium bis[mu-tartrato(4-)]diantimonate(2-) trihydrate  (ISO)
dipyridamole  (ISO)
diquat  (ISO)
disodium selenite  (EXP,ISO)
disulfiram  (ISO)
dizocilpine maleate  (EXP,ISO)
dobutamine  (EXP)
donepezil hydrochloride  (ISO)
dopamine  (EXP,ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
doxycycline  (ISO)
ebselen  (ISO)
elemental selenium  (EXP)
ellagic acid  (ISO)
endosulfan  (ISO)
Enterolactone  (ISO)
entinostat  (ISO)
epoxiconazole  (ISO)
ergotamine  (EXP)
ergothioneine  (EXP)
Erionite  (EXP)
erythromycin A  (ISO)
estra-1,3,5(10)-triene-3,16beta-diol  (EXP)
estriol  (EXP)
etacrynic acid  (ISO)
ethanol  (EXP,ISO)
ethylene glycol bis(2-aminoethyl)tetraacetic acid  (ISO)
eticlopride(1+)  (EXP)
etoposide  (EXP,ISO)
famotidine  (ISO)
farnesyl diphosphate  (ISO)
fenfluramine  (EXP)
fentanyl  (EXP)
fenthion  (ISO)
ferric oxide  (ISO)
ferroheme b  (ISO)
ferrosoferric oxide  (ISO)
fingolimod hydrochloride  (ISO)
fisetin  (ISO)
Flavokawain A  (ISO)
flecainide  (ISO)
flumequine  (ISO)
fluoranthene  (ISO)
fluoxetine  (EXP,ISO)
flurbiprofen  (EXP,ISO)
folic acid  (ISO)
folpet  (ISO)
formaldehyde  (EXP,ISO)
formononetin  (ISO)
fotemustine  (ISO)
fructose  (EXP)
fulvestrant  (ISO)
furan  (EXP)
furosemide  (EXP,ISO)
gamma-hexachlorocyclohexane  (EXP,ISO)
gamma-tocopherol  (ISO)
gefitinib  (ISO)
Geniposide pentaacetate  (EXP)
genistein  (EXP,ISO)
gentamycin  (EXP)
geraniol  (ISO)
ginsenoside Rb1  (ISO)
ginsenoside Re  (ISO)
ginsenoside Rg1  (ISO)
glucaric acid  (ISO)
glucose  (EXP,ISO)
glufosinate  (ISO)
glutathione  (ISO)
glycidol  (EXP)
glyphosate  (EXP,ISO)
gold atom  (ISO)
gold(0)  (ISO)
haloperidol  (EXP,ISO)
halothane  (EXP)
helioxanthin  (ISO)
heme b  (ISO)
hemin  (ISO)
heparin  (EXP,ISO)
herbimycin  (EXP)
heroin  (EXP)
hexachlorobenzene  (EXP)
Hexamethonium  (EXP)
histamine  (ISO)
hydralazine  (EXP)
hydrogen chloride  (EXP)
hydrogen peroxide  (EXP,ISO)
hydrogen sulfide  (ISO)
hydroquinone  (ISO)
hydroxyurea  (ISO)
hypochlorous acid  (ISO)
ibuprofen  (ISO)
icariin  (ISO)
idazoxan  (ISO)
ifosfamide  (EXP)
imipramine  (EXP)
indapamide  (EXP)
Indeno[1,2,3-cd]pyrene  (ISO)
indole-3-methanol  (EXP)
indometacin  (EXP)
iodoform  (ISO)
ionomycin  (EXP,ISO)
iprodione  (ISO)
irinotecan  (ISO)
iron atom  (EXP)
iron dextran  (EXP)
iron dichloride  (ISO)
iron(0)  (EXP)
iron(III) nitrilotriacetate  (ISO)
isobutanol  (ISO)
isoflurane  (EXP)
isoprenaline  (EXP,ISO)
isorhapontigenin  (EXP)
isotretinoin  (ISO)
istradefylline  (EXP)
josamycin  (ISO)
kaempferol  (ISO)
kainic acid  (EXP,ISO)
kenpaullone  (EXP)
ketamine  (EXP)
ketorolac  (EXP)
KT 5823  (ISO)
L-ascorbic acid  (ISO)
L-methionine  (ISO)
L-selenocysteine  (ISO)
lanthanum atom  (EXP)
lanthanum trichloride  (EXP)
lead diacetate  (EXP,ISO)
lead nitrate  (ISO)
lead(0)  (EXP,ISO)
leflunomide  (ISO)
levamisole  (ISO)
Licochalcone B  (ISO)
lidocaine  (EXP,ISO)
linalool  (EXP)
lipoic acid  (EXP)
lipopolysaccharide  (EXP,ISO)
lithium atom  (EXP,ISO)
lithium chloride  (EXP)
lithium hydride  (EXP,ISO)
losartan  (EXP,ISO)
lovastatin  (EXP,ISO)
luteolin  (EXP,ISO)
luteolin 7-O-beta-D-glucoside  (ISO)
LY294002  (ISO)
lycopene  (ISO)
lysergic acid diethylamide  (EXP)
m-Chlorophenylbiguanide  (EXP)
mancozeb  (ISO)
maneb  (EXP,ISO)
manganese atom  (EXP,ISO)
manganese(0)  (EXP,ISO)
manganese(II) chloride  (EXP,ISO)
masoprocol  (ISO)
mebendazole  (ISO)
mechlorethamine  (ISO)
MeIQx  (ISO)
melatonin  (EXP)
menadione  (ISO)
mercury atom  (EXP)
mercury dichloride  (EXP,ISO)
mercury(0)  (EXP)
metformin  (EXP,ISO)
methamidophos  (EXP)
methamphetamine  (EXP,ISO)
methapyrilene  (EXP)
methotrexate  (EXP,ISO)
methoxychlor  (EXP)
methyl methanesulfonate  (ISO)
methylarsonic acid  (ISO)
methylglyoxal  (ISO)
methylisothiazolinone  (ISO)
methylmercury chloride  (EXP,ISO)
methylphenidate  (EXP,ISO)
metoprolol  (EXP)
metyrapone  (EXP)
miconazole  (EXP)
microcystin-LR  (ISO)
Midecamycin  (ISO)
mifepristone  (EXP)
mitomycin C  (ISO)
ML-7  (EXP)
modafinil  (ISO)
Mofezolac (TN)  (EXP)
mono(2-ethylhexyl) phthalate  (EXP,ISO)
monocrotophos  (EXP)
monosodium L-glutamate  (EXP)
morin  (EXP)
morphine  (EXP,ISO)
Muconic dialdehyde  (ISO)
muscimol  (EXP)
mycophenolic acid  (ISO)
myricetin  (ISO)
N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine  (ISO)
N-[2-(4-bromocinnamylamino)ethyl]isoquinoline-5-sulfonamide  (EXP,ISO)
N-[2-[4-(2-methoxyphenyl)-1-piperazinyl]ethyl]-N-(2-pyridinyl)cyclohexanecarboxamide  (EXP)
N-acetyl-L-cysteine  (EXP,ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (EXP,ISO)
N-ethyl-N-nitrosourea  (ISO)
N-methyl-4-phenylpyridinium  (EXP,ISO)
N-methyl-N-nitrosourea  (EXP)
N-methylformamide  (ISO)
N-nitrosodiethylamine  (EXP,ISO)
N-Nitrosopyrrolidine  (ISO)
N-phenylthiourea  (ISO)
N1'-[2-[[5-[(dimethylamino)methyl]-2-furanyl]methylthio]ethyl]-N1-methyl-2-nitroethene-1,1-diamine  (EXP)
nabumetone  (ISO)
nafadotride  (EXP)
naloxone  (EXP,ISO)
naphthalene  (ISO)
naringin  (ISO)
nefazodone  (ISO)
neurotensin  (ISO)
nicardipine  (EXP)
nickel atom  (EXP,ISO)
nickel dichloride  (EXP)
nickel subsulfide  (EXP,ISO)
nickel sulfate  (ISO)
niclosamide  (ISO)
nicotinamide  (EXP)
nicotine  (EXP,ISO)
nifedipine  (EXP,ISO)
nilotinib  (ISO)
nimodipine  (EXP,ISO)
nimustine  (ISO)
nitrofen  (EXP)
nitrogen dioxide  (EXP)
nitroglycerin  (EXP,ISO)
nitroprusside  (EXP,ISO)
nobiletin  (EXP)
Nodularin  (ISO)
nomifensine  (EXP)
Nonylphenol  (ISO)
obeticholic acid  (ISO)
ochratoxin A  (EXP,ISO)
okadaic acid  (EXP,ISO)
olanzapine  (EXP)
omega-conotoxin GVIA  (EXP)
organoselenium compound  (ISO)
oroxylin A  (ISO)
oxaliplatin  (EXP,ISO)
oxidopamine  (EXP)
Oxotremorine  (EXP)
oxotremorine M  (ISO)
oxycodone  (EXP)
oxytocin  (EXP)
ozone  (EXP,ISO)
p-chloromercuribenzoic acid  (ISO)
p-menthan-3-ol  (EXP)
p-tert-Amylphenol  (EXP)
palytoxin  (ISO)
paracetamol  (EXP,ISO)
paraoxon  (ISO)
paraquat  (EXP,ISO)
parathion-methyl  (EXP)
patulin  (EXP,ISO)
PCB138  (EXP)
PD 0325901  (EXP,ISO)
pentachlorobenzene  (EXP)
pentachlorophenol  (ISO)
pentetrazol  (EXP,ISO)
pentobarbital  (EXP,ISO)
Pentoxifylline  (ISO)
perchlorate  (EXP)
perfluorooctane-1-sulfonic acid  (EXP,ISO)
perfluorooctanoic acid  (EXP,ISO)
perindopril  (EXP)
permethrin  (EXP,ISO)
peroxynitrous acid  (ISO)
phencyclidine  (EXP)
phenethyl isothiocyanate  (ISO)
phenformin  (EXP)
phenobarbital  (EXP,ISO)
Phenoxybenzamine  (EXP)
phenylephrine  (EXP,ISO)
phenytoin  (EXP)
PhIP  (EXP,ISO)
phorbol 12,13-dibutanoate  (EXP)
phorbol 13-acetate 12-myristate  (EXP,ISO)
phorone  (EXP)
phosgene  (ISO)
phylloquinone  (ISO)
physostigmine  (EXP)
picrotoxin  (EXP)
picrotoxinin  (EXP)
pimozide  (EXP)
pioglitazone  (EXP)
piperine  (ISO)
piperonyl butoxide  (ISO)
pipoxolan  (ISO)
pirenzepine  (EXP)
pirinixic acid  (ISO)
platycodin D  (ISO)
poly(ethylene)  (ISO)
potassium atom  (EXP,ISO)
potassium chloride  (EXP)
potassium chromate  (ISO)
potassium cyanide  (EXP)
prazosin  (EXP,ISO)
pregabalin  (EXP)
pregnenolone 16alpha-carbonitrile  (ISO)
progesterone  (EXP,ISO)
promegestone  (ISO)
propan-2-ol  (ISO)
propanal  (ISO)
propofol  (EXP)
propranolol  (EXP)
prostaglandin E2  (ISO)
protein kinase inhibitor  (EXP)
protoporphyrin  (ISO)
pterostilbene  (ISO)
puerarin  (ISO)
putrescine  (EXP)
pyrethrins  (ISO)
pyridine  (EXP)
pyrimethamine  (ISO)
pyrithiamine  (EXP)
pyrrolidine dithiocarbamate  (EXP,ISO)
quartz  (ISO)
quercetin  (EXP,ISO)
quercetin 3-O-beta-D-glucofuranoside  (EXP)
quercetin 3-O-beta-D-glucopyranoside  (EXP)
quinapril hydrochloride  (EXP)
quinolin-8-ol  (ISO)
quinolinic acid  (EXP)
quinomethionate  (ISO)
quinpirole  (EXP)
rac-lactic acid  (ISO)
ranitidine  (EXP)
reactive oxygen species  (ISO)
reboxetine  (EXP)
reserpine  (EXP)
resiniferatoxin  (EXP,ISO)
resveratrol  (EXP,ISO)
rimonabant  (EXP,ISO)
risperidone  (EXP,ISO)
ritonavir  (ISO)
Rizatriptan benzoate  (EXP)
Ro 31-8220  (ISO)
rosmarinic acid  (EXP)
rotenone  (EXP,ISO)
rottlerin  (ISO)
rutin  (ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
S-butyl-DL-homocysteine (S,R)-sulfoximine  (EXP,ISO)
SB 203580  (EXP,ISO)
SB 206553  (EXP)
SB 431542  (ISO)
SCH 23390  (EXP)
SCH772984  (EXP)
sclareol  (ISO)
scopolamine  (EXP,ISO)
selenium atom  (EXP)
selenomethionine  (ISO)
selumetinib  (ISO)
serotonin  (EXP)
serpentine asbestos  (EXP)
sertraline  (EXP,ISO)
Shikonin  (ISO)
silicon dioxide  (EXP,ISO)
silver atom  (ISO)
silver(0)  (ISO)
silver(1+) nitrate  (ISO)
simvastatin  (EXP,ISO)
SKF 38393  (EXP,ISO)
SL-327  (EXP,ISO)
sodium arsenate  (ISO)
sodium arsenite  (EXP,ISO)
sodium azide  (EXP)
sodium chloride  (EXP,ISO)
sodium dichromate  (EXP,ISO)
sodium dodecyl sulfate  (EXP,ISO)
sodium fluoride  (ISO)
sodium perchlorate  (EXP)
Soman  (EXP)
spiramycin II  (ISO)
staurosporine  (EXP)
sterigmatocystin  (EXP)
stilben-4-ol  (ISO)
stilbene-4,4'-diol  (ISO)
streptozocin  (ISO)
styrene  (ISO)
sulfur dioxide  (EXP)
sulindac  (ISO)
sumatriptan  (ISO)
superoxide  (ISO)
tacrine  (EXP)
tacrolimus hydrate  (ISO)
tamoxifen  (EXP,ISO)
tandospirone citrate  (ISO)
Tanshinone I  (ISO)
taurine  (EXP)
taurolithocholic acid  (ISO)
tauroursodeoxycholic acid  (ISO)
tebufenpyrad  (ISO)
telmisartan  (EXP)
terbufos  (ISO)
terbutaline  (EXP)
tert-butyl hydroperoxide  (ISO)
testosterone  (EXP,ISO)
Tetrachlorobisphenol A  (EXP,ISO)
tetrachloroethene  (ISO)
tetrachloromethane  (EXP,ISO)
tetramethylpyrazine  (EXP)
tetrathiomolybdate(2-)  (ISO)
tetrodotoxin  (EXP)
thalidomide  (ISO)
thapsigargin  (ISO)
theophylline  (EXP)
thimerosal  (ISO)
thioacetamide  (EXP)
thiourea  (ISO)
thiram  (ISO)
thymol  (ISO)
thymol sulfate(1-)  (ISO)
thymoquinone  (EXP)
titanium dioxide  (EXP,ISO)
tocopherol  (ISO)
toluene  (ISO)
topotecan  (EXP,ISO)
torcetrapib  (ISO)
toremifene  (ISO)
trans-stilbene-4,4'-diol  (ISO)
transplatin  (EXP,ISO)
tranylcypromine  (EXP)
triacsin C  (ISO)
triazolam  (ISO)
tributylstannane  (EXP)
trichloroethene  (EXP)
trichostatin A  (ISO)
triphenyl phosphate  (ISO)
triptonide  (ISO)
troglitazone  (EXP,ISO)
tropan-3alpha-yl 3-hydroxy-2-phenylpropanoate  (EXP,ISO)
Tropicamide  (EXP)
trovafloxacin  (ISO)
tubocurarine  (ISO)
tungsten  (EXP,ISO)
tunicamycin  (ISO)
tyrphostin AG 1478  (EXP,ISO)
U-73122  (EXP)
uranium atom  (ISO)
urethane  (EXP,ISO)
Ursonic acid  (ISO)
valproic acid  (EXP,ISO)
valsartan  (EXP)
vanadyl sulfate  (ISO)
vancomycin  (ISO)
vanoxerine dihydrochloride  (EXP)
verapamil  (ISO)
veratridine  (EXP,ISO)
vinclozolin  (EXP)
vincristine  (EXP)
vitamin D  (ISO)
vitamin E  (ISO)
WIN 55212-2  (ISO)
wortmannin  (EXP,ISO)
xanomeline  (EXP)
Xanthatin  (ISO)
xanthohumol  (ISO)
xanthones  (ISO)
zearalenone  (ISO)
zidovudine  (ISO)
zinc atom  (EXP,ISO)
zinc dichloride  (ISO)
zinc oxide  (ISO)
zinc protoporphyrin  (ISO)
zinc sulfate  (ISO)
zinc(0)  (EXP,ISO)
zoledronic acid  (EXP,ISO)
zonisamide  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
cellular response to calcium ion  (ISO)
cellular response to epidermal growth factor stimulus  (IEP)
cellular response to hormone stimulus  (IEP)
cellular response to hypoxia  (IEP)
cellular response to parathyroid hormone stimulus  (IEP)
cellular response to phorbol 13-acetate 12-myristate  (IEP)
cellular response to prolactin  (IEP)
cellular response to reactive oxygen species  (ISO)
cellular response to transforming growth factor beta stimulus  (IEP)
cellular response to tumor necrosis factor  (IEP)
cellular response to zinc ion starvation  (IEP)
cerebral cortex development  (IMP)
conditioned taste aversion  (IEP)
female pregnancy  (IEP)
medium-term memory  (IMP)
mononuclear cell differentiation  (IEP)
myoblast proliferation  (IEP)
nervous system development  (ISO)
neural retina development  (IEP)
neuron differentiation  (IMP)
osteoclast differentiation  (ISO)
positive regulation of DNA-templated transcription  (ISO)
positive regulation of miRNA transcription  (IDA,ISO)
positive regulation of osteoclast differentiation  (ISO)
positive regulation of transcription by RNA polymerase II  (ISO)
regulation of DNA-templated transcription  (ISO)
regulation of gene expression  (ISO)
regulation of transcription by RNA polymerase II  (IBA,ISO)
response to activity  (IEP)
response to cAMP  (IEP)
response to corticosterone  (IEP)
response to cytokine  (IEP)
response to ethanol  (IEP)
response to forskolin  (IEP)
response to gravity  (IEP)
response to immobilization stress  (IEP)
response to insulin  (IEP)
response to light stimulus  (IEP)
response to lipopolysaccharide  (IEP)
response to mechanical stimulus  (IEP)
response to muscle stretch  (ISO)
response to progesterone  (IEP)
response to steroid hormone  (IEP)
response to toxic substance  (IEP)
response to xenobiotic stimulus  (IEP,ISO)
skeletal muscle cell differentiation  (ISO)
skeletal muscle cell proliferation  (IEP)
SMAD protein signal transduction  (ISO)
transcription by RNA polymerase II  (IMP,ISO)
transforming growth factor beta receptor signaling pathway  (ISO)

Cellular Component

References

References - curated
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38. Relapse to cocaine-seeking increases activity-regulated gene expression differentially in the striatum and cerebral cortex of rats following short or long periods of abstinence. Hearing MC, etal., Brain Struct Funct. 2008 Sep;213(1-2):215-27. doi: 10.1007/s00429-008-0182-4. Epub 2008 May 17.
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41. Scutellaria baicalensis alleviates cantharidin-induced rat hemorrhagic cystitis through inhibition of cyclooxygenase-2 overexpression. Huan SK, etal., Molecules. 2012 May 25;17(6):6277-89. doi: 10.3390/molecules17066277.
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44. Repetitive stretch induces c-fos and myogenin mRNA within several hours in skeletal muscle removed from rats. Ikeda S, etal., Arch Phys Med Rehabil 2003 Mar;84(3):419-23.
45. Similarity of distributions of spinal c-Fos and plasma extravasation after acute chemical irritation of the bladder and the prostate. Ishigooka M, etal., J Urol 2000 Nov;164(5):1751-6.
46. N-(2-hydroxy phenyl) acetamide produces profound inhibition of c-Fos protein and mRNA expression in the brain of adjuvant-induced arthritic rats. Jawed H, etal., Mol Cell Biochem. 2014 Feb;387(1-2):81-90. doi: 10.1007/s11010-013-1873-6. Epub 2013 Nov 2.
47. Clusterin regulates ß-amyloid toxicity via Dickkopf-1-driven induction of the wnt-PCP-JNK pathway. Killick R, etal., Mol Psychiatry. 2014 Jan;19(1):88-98. doi: 10.1038/mp.2012.163. Epub 2012 Nov 20.
48. Vitamin B-6-supplemented diets compared with a low vitamin B-6 diet suppress azoxymethane-induced colon tumorigenesis in mice by reducing cell proliferation. Komatsu SI, etal., J Nutr. 2001 Aug;131(8):2204-7.
49. Administration of ricin induces a severe inflammatory response via nonredundant stimulation of ERK, JNK, and P38 MAPK and provides a mouse model of hemolytic uremic syndrome. Korcheva V, etal., Am J Pathol. 2005 Jan;166(1):323-39.
50. Acute nicotine enhances spontaneous recovery of contextual fear and changes c-fos early gene expression in infralimbic cortex, hippocampus, and amygdala. Kutlu MG, etal., Learn Mem. 2016 Jul 15;23(8):405-14. doi: 10.1101/lm.042655.116. Print 2016 Aug.
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PMID:21225009   PMID:21285311   PMID:21287731   PMID:21319893   PMID:21340718   PMID:21341886   PMID:21376756   PMID:21404708   PMID:21439021   PMID:21507338   PMID:21524663   PMID:21525724  
PMID:21609285   PMID:21723961   PMID:21736812   PMID:21925583   PMID:22000863   PMID:22094385   PMID:22097274   PMID:22147266   PMID:22178607   PMID:22284419   PMID:22323725   PMID:22387553  
PMID:22432135   PMID:22446013   PMID:22455809   PMID:22456943   PMID:22462413   PMID:22516520   PMID:22521827   PMID:22534624   PMID:22611921   PMID:22613772   PMID:22693577   PMID:22771876  
PMID:22792289   PMID:22846568   PMID:22851043   PMID:22917527   PMID:22960202   PMID:22982514   PMID:23018815   PMID:23158763   PMID:23181383   PMID:23183219   PMID:23195113   PMID:23233946  
PMID:23306170   PMID:23333670   PMID:23395171   PMID:23591003   PMID:23593280   PMID:23624190   PMID:23660497   PMID:23818940   PMID:23870463   PMID:23922220   PMID:23980096   PMID:24023832  
PMID:24049115   PMID:24118230   PMID:24184327   PMID:24292370   PMID:24308227   PMID:24316406   PMID:24321404   PMID:24333564   PMID:24567082   PMID:24598462   PMID:24915133   PMID:24939298  
PMID:24978397   PMID:25031700   PMID:25354492   PMID:25446350   PMID:25474904   PMID:25592718   PMID:25674230   PMID:25710066   PMID:26072392   PMID:26082062   PMID:26087133   PMID:26216073  
PMID:26314630   PMID:26452320   PMID:26475860   PMID:26514923   PMID:26774022   PMID:27028464   PMID:27030665   PMID:27078100   PMID:27164028   PMID:27239846   PMID:27384705   PMID:27865919  
PMID:27923581   PMID:28185007   PMID:28469203   PMID:28472857   PMID:28634074   PMID:28730575   PMID:28764933   PMID:29093345   PMID:29165002   PMID:29214513   PMID:29225069   PMID:29450645  
PMID:29938674   PMID:30244018   PMID:30851318   PMID:31257474   PMID:31364821   PMID:31373119   PMID:31408622   PMID:31968225   PMID:32235506   PMID:32702030   PMID:32785417   PMID:33183026  
PMID:33212101   PMID:33239732   PMID:33940958   PMID:35244314   PMID:36152451   PMID:36216550   PMID:36343695   PMID:36344400   PMID:36690096   PMID:37567256   PMID:37858915   PMID:38228055  
PMID:38338735  


Genomics

Comparative Map Data
Fos
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr86110,852,188 - 110,855,054 (+)NCBIGRCr8
mRatBN7.26105,121,170 - 105,124,036 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl6105,121,170 - 105,124,036 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx6105,290,640 - 105,293,508 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.06105,589,531 - 105,592,399 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.06104,959,176 - 104,962,044 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.06109,300,433 - 109,303,299 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl6109,300,433 - 109,303,299 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.06116,249,742 - 116,252,608 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.46109,559,135 - 109,562,001 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.16109,562,609 - 109,566,002 (+)NCBI
Celera6102,942,464 - 102,945,330 (+)NCBICelera
Cytogenetic Map6q31NCBI
FOS
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381475,278,828 - 75,282,230 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1475,278,826 - 75,283,190 (+)EnsemblGRCh38hg38GRCh38
GRCh371475,745,531 - 75,748,933 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361474,815,284 - 74,818,666 (+)NCBINCBI36Build 36hg18NCBI36
Build 341474,815,283 - 74,818,666NCBI
Celera1455,783,567 - 55,787,023 (+)NCBICelera
Cytogenetic Map14q24.3NCBI
HuRef1455,913,924 - 55,917,380 (+)NCBIHuRef
CHM1_11475,683,266 - 75,686,721 (+)NCBICHM1_1
T2T-CHM13v2.01469,488,228 - 69,491,630 (+)NCBIT2T-CHM13v2.0
Fos
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391285,520,664 - 85,524,048 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1285,520,664 - 85,524,047 (+)EnsemblGRCm39 Ensembl
GRCm381285,473,890 - 85,477,274 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1285,473,890 - 85,477,273 (+)EnsemblGRCm38mm10GRCm38
MGSCv371286,814,851 - 86,818,219 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361286,363,004 - 86,366,372 (+)NCBIMGSCv36mm8
Celera1286,933,225 - 86,936,593 (+)NCBICelera
Cytogenetic Map12D2NCBI
cM Map1239.7NCBI
Fos
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955523305,728 - 310,728 (-)EnsemblChiLan1.0
ChiLan1.0NW_004955523307,181 - 310,728 (-)NCBIChiLan1.0ChiLan1.0
FOS
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21576,362,508 - 76,366,629 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11475,579,607 - 75,583,133 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01455,832,570 - 55,835,984 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11474,676,316 - 74,679,766 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1474,676,316 - 74,679,766 (+)Ensemblpanpan1.1panPan2
FOS
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1848,330,856 - 48,334,273 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl848,331,026 - 48,333,467 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha848,014,730 - 48,018,137 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0848,558,356 - 48,561,763 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl848,558,343 - 48,561,758 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1848,229,017 - 48,232,423 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0848,250,295 - 48,253,702 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0848,649,028 - 48,652,435 (+)NCBIUU_Cfam_GSD_1.0
Fos
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440864027,680,843 - 27,684,228 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364884,384,705 - 4,388,122 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364884,384,710 - 4,388,118 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
FOS
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl798,449,349 - 98,455,554 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1798,449,508 - 98,451,971 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.27104,293,828 - 104,296,291 (+)NCBISscrofa10.2Sscrofa10.2susScr3
FOS
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12452,497,465 - 52,501,161 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2452,497,521 - 52,501,514 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605340,725,132 - 40,728,594 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Fos
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473426,423,079 - 26,427,732 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473426,424,053 - 26,427,431 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Fos
10 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:143
Count of miRNA genes:105
Interacting mature miRNAs:116
Transcripts:ENSRNOT00000010712
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
12801411Schws8Schwannoma susceptibility QTL 8nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)694968928139968928Rat
1331797Bp213Blood pressure QTL 2133.291arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)6104085867128713626Rat
1331799Bp211Blood pressure QTL 2113.66407arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)672202632130919985Rat
1358355Srcrt4Stress Responsive Cort QTL 46.39blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)6100364669140994061Rat
2313399Anxrr28Anxiety related response QTL 28aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)6100671796132340886Rat
1331725Bp212Blood pressure QTL 2123.52475arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)693701310128713626Rat
1331789Rf37Renal function QTL 373.224kidney blood vessel physiology trait (VT:0100012)absolute change in renal vascular resistance (CMO:0001900)672202632115200186Rat
1331722Thshl1Thyroid stimulating hormone level QTL 111.70.0001blood thyroid-stimulating hormone amount (VT:0005119)serum thyroid stimulating hormone level (CMO:0001248)689762877106752806Rat
8552796Vie3Viral induced encephalitis QTL 32.6brain integrity trait (VT:0010579)encephalitis incidence/prevalence measurement (CMO:0002361)696833997140994061Rat
4145119Mcs25Mammary carcinoma susceptibility QTL 250.0001mammary gland integrity trait (VT:0010552)ratio of deaths to total study population during a period of time (CMO:0001023)610894415110548006Rat
1581563Uae33Urinary albumin excretion QTL 33urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)672227641130729205Rat
10054138Gmadr3Adrenal mass QTL 33.680.00045adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)685140138130140138Rat
61414Pia3Pristane induced arthritis QTL 34.5joint integrity trait (VT:0010548)post-insult time to onset of experimental arthritis (CMO:0001450)694968928137848904Rat
724524Uae2Urinary albumin excretion QTL 22.70.0005urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)673463459109394713Rat
737827Hcar11Hepatocarcinoma resistance QTL 114.4liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)682523650110548006Rat
1641904Alcrsp4Alcohol response QTL 4response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)667262953112262953Rat
724513Uae14Urinary albumin excretion QTL 146.5urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)685311061133478515Rat
2303624Vencon5Ventilatory control QTL 54.45respiration trait (VT:0001943)minute ventilation (CMO:0000132)688047916133047916Rat
1576309Emca7Estrogen-induced mammary cancer QTL 74mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)615107216107351382Rat
731173Uae22Urinary albumin excretion QTL 2210.1urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)665531555140994061Rat
10054123Srcrt6Stress Responsive Cort QTL 62.50.0043blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)685140138130140138Rat
724536Uae7Urinary albumin excretion QTL 73.5urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)672202632130729475Rat
70196BpQTLcluster7Blood pressure QTL cluster 76.82arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)672202632117202632Rat
1576302Schws4Schwannoma susceptibility QTL 40.0078nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)683190345106747639Rat
1581550Pur8Proteinuria QTL 8urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)672227641130729205Rat
1300075Glom7Glomerulus QTL 75.60.0000002kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli not directly contacting the kidney surface (CMO:0001002)671201409116201409Rat
738034Anxrr5Anxiety related response QTL 55.9exploratory behavior trait (VT:0010471)percentage of entries into a discrete space in an experimental apparatus (CMO:0000961)684130881129130881Rat
2290393Uae37Urinary albumin excretion QTL 370.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)665531555140994061Rat
12801471Schws9Schwannoma susceptibility QTL 9nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)661747639106747639Rat
1300076Glom8Glomerulus QTL 879e-09kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli directly contacting the kidney surface (CMO:0001001)686894788131894788Rat

Markers in Region
Fos  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.26105,122,222 - 105,122,470 (+)MAPPERmRatBN7.2
Rnor_6.06109,301,486 - 109,301,733NCBIRnor6.0
Rnor_5.06116,251,308 - 116,251,555UniSTSRnor5.0
RGSC_v3.46109,560,188 - 109,560,435UniSTSRGSC3.4
Celera6102,943,517 - 102,943,764UniSTS
Cytogenetic Map6q31UniSTS
WI-19801  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.26105,123,847 - 105,124,149 (+)MAPPERmRatBN7.2
Rnor_6.06109,303,111 - 109,303,412NCBIRnor6.0
Rnor_5.06116,249,629 - 116,249,930UniSTSRnor5.0
RGSC_v3.46109,561,813 - 109,562,114UniSTSRGSC3.4
Celera6102,945,142 - 102,945,443UniSTS
Cytogenetic Map6q31UniSTS
PMC151804P3  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.26105,122,906 - 105,123,431 (+)MAPPERmRatBN7.2
Rnor_6.06109,302,170 - 109,302,694NCBIRnor6.0
Rnor_5.06116,250,347 - 116,250,871UniSTSRnor5.0
RGSC_v3.46109,560,872 - 109,561,396UniSTSRGSC3.4
Celera6102,944,201 - 102,944,725UniSTS
Cytogenetic Map6q31UniSTS
PMC108124P1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.26105,122,435 - 105,123,350 (+)MAPPERmRatBN7.2
Rnor_6.06109,301,699 - 109,302,613NCBIRnor6.0
Rnor_5.06116,250,428 - 116,251,342UniSTSRnor5.0
RGSC_v3.46109,560,401 - 109,561,315UniSTSRGSC3.4
Celera6102,943,730 - 102,944,644UniSTS
Cytogenetic Map6q31UniSTS
PMC321436P2  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.26105,122,914 - 105,123,136 (+)MAPPERmRatBN7.2
Rnor_6.06109,302,178 - 109,302,399NCBIRnor6.0
Rnor_5.06116,250,642 - 116,250,863UniSTSRnor5.0
RGSC_v3.46109,560,880 - 109,561,101UniSTSRGSC3.4
Celera6102,944,209 - 102,944,430UniSTS
Cytogenetic Map6q31UniSTS
PMC99986P2  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.26105,120,896 - 105,121,180 (+)MAPPERmRatBN7.2
Rnor_6.06109,300,160 - 109,300,443NCBIRnor6.0
Rnor_5.06116,252,598 - 116,252,881UniSTSRnor5.0
RGSC_v3.46109,558,862 - 109,559,145UniSTSRGSC3.4
Celera6102,942,191 - 102,942,474UniSTS
Cytogenetic Map6q31UniSTS
BP240034A10G4  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.26105,124,058 - 105,124,364 (+)MAPPERmRatBN7.2
Rnor_6.06109,303,322 - 109,303,627NCBIRnor6.0
Rnor_5.06116,249,414 - 116,249,719UniSTSRnor5.0
RGSC_v3.46109,562,024 - 109,562,329UniSTSRGSC3.4
Celera6102,945,353 - 102,945,658UniSTS
Cytogenetic Map6q31UniSTS
Fos  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.26105,124,316 - 105,124,496 (+)MAPPERmRatBN7.2
Rnor_6.06109,303,580 - 109,303,759NCBIRnor6.0
Rnor_5.06116,249,282 - 116,249,461UniSTSRnor5.0
RGSC_v3.46109,562,282 - 109,562,461UniSTSRGSC3.4
Celera6102,945,611 - 102,945,790UniSTS
Cytogenetic Map6q31UniSTS
Fos  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.26105,124,370 - 105,124,546 (+)MAPPERmRatBN7.2
Rnor_6.06109,303,634 - 109,303,809NCBIRnor6.0
Rnor_5.06116,249,232 - 116,249,407UniSTSRnor5.0
RGSC_v3.46109,562,336 - 109,562,511UniSTSRGSC3.4
Celera6102,945,665 - 102,945,840UniSTS
Cytogenetic Map6q31UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31

Sequence


Ensembl Acc Id: ENSRNOT00000010712   ⟹   ENSRNOP00000010712
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl6105,121,170 - 105,124,036 (+)Ensembl
Rnor_6.0 Ensembl6109,300,433 - 109,303,299 (+)Ensembl
RefSeq Acc Id: NM_022197   ⟹   NP_071533
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr86110,852,188 - 110,855,054 (+)NCBI
mRatBN7.26105,121,170 - 105,124,036 (+)NCBI
Rnor_6.06109,300,433 - 109,303,299 (+)NCBI
Rnor_5.06116,249,742 - 116,252,608 (-)NCBI
RGSC_v3.46109,559,135 - 109,562,001 (+)RGD
Celera6102,942,464 - 102,945,330 (+)RGD
Sequence:
RefSeq Acc Id: NP_071533   ⟸   NM_022197
- UniProtKB: Q4FDN1 (UniProtKB/Swiss-Prot),   P12841 (UniProtKB/Swiss-Prot),   A6JE29 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000010712   ⟸   ENSRNOT00000010712
Protein Domains
bZIP

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P12841-F1-model_v2 AlphaFold P12841 1-380 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13694742
Promoter ID:EPDNEW_R5267
Type:single initiation site
Name:Fos_1
Description:Fos proto-oncogene, AP-1 transcription factor subunit
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.06109,300,435 - 109,300,495EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2626 AgrOrtholog
BioCyc Gene G2FUF-36778 BioCyc
Ensembl Genes ENSRNOG00000008015 Ensembl, UniProtKB/Swiss-Prot
  ENSRNOG00055025291 UniProtKB/Swiss-Prot
  ENSRNOG00060023383 UniProtKB/Swiss-Prot
  ENSRNOG00065024997 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000010712.4 UniProtKB/Swiss-Prot
  ENSRNOT00055043608 UniProtKB/Swiss-Prot
  ENSRNOT00060040477 UniProtKB/Swiss-Prot
  ENSRNOT00065042954 UniProtKB/Swiss-Prot
Gene3D-CATH 1.20.5.170 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro AP-1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  bZIP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  bZIP_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:314322 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene Fos ENTREZGENE
PANTHER PTHR23351 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR23351:SF4 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam bZIP_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Fos PhenoGen
PRINTS LEUZIPPRFOS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE BZIP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  BZIP_BASIC UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000008015 RatGTEx
  ENSRNOG00055025291 RatGTEx
  ENSRNOG00060023383 RatGTEx
  ENSRNOG00065024997 RatGTEx
SMART BRLZ UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF57959 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A6JE29 ENTREZGENE, UniProtKB/TrEMBL
  A6JE31_RAT UniProtKB/TrEMBL
  FOS_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  Q4FDN1 ENTREZGENE
  Q5G6W2_RAT UniProtKB/TrEMBL
  Q5G6W3_RAT UniProtKB/TrEMBL
  Q5U7E3_RAT UniProtKB/TrEMBL
  Q5U873_RAT UniProtKB/TrEMBL
  Q5U874_RAT UniProtKB/TrEMBL
  Q5U875_RAT UniProtKB/TrEMBL
UniProt Secondary Q4FDN1 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2017-03-07 Fos  Fos proto-oncogene, AP-1 transcription factor subunit  Fos  FBJ osteosarcoma oncogene  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-02-15 Fos  FBJ osteosarcoma oncogene  Fos  FBJ murine osteosarcoma viral oncogene homolog  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-02-28 Fos  FBJ murine osteosarcoma viral oncogene homolog  c-fos  c-fos oncogene  Data merged from RGD:735054 737654 APPROVED
2005-01-20 Fos  FBJ murine osteosarcoma viral oncogene homolog    v-fos FBJ murine osteosarcoma viral oncogene homolog  Name updated 1299863 APPROVED
2002-06-10 Fos  v-fos FBJ murine osteosarcoma viral oncogene homolog      Name updated 70585 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_function may play a role in androgen regulated apoptosis 70259
gene_physical_interaction forms heterodimeric complexes with proteins of the Jun family which then bind to the AP-1 gene promoter site to regulate gene expression 1302797
gene_process increases the intracellular calcium ion levels which helps in the degradation of phosphatidyl inositol and activation of protein kinase C 70259
gene_process increases transcription associated with cell death in prostate regression 70259
gene_regulation expression is induced in response to airpuff startle in hypothalamus, thalamus, midbrain, pons and medulla 1358971