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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2626
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Fos
Name: Fos proto-oncogene, AP-1 transcription factor subunit
Acc ID: CHEBI:28748
Term: doxorubicin
Definition: An anthracycline antibiotic that has formula C27H29NO11.
Chemical ID: MESH:D004317
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Fosaffects expressionISOFOS (Homo sapiens)6480464CTDDoxorubicin affects the expression of FOS mRNAPMID:15205334 PMID:31470548
Fosdecreases expressionISOFOS (Homo sapiens)6480464CTDDoxorubicin results in decreased expression of FOS mRNAPMID:26320837 PMID:29803840
Fosincreases expressionISOFos (Mus musculus)6480464CTDDoxorubicin results in increased expression of FOS mRNAPMID:21040762 PMID:22712078
Fosincreases expressionISOFOS (Homo sapiens)6480464CTDDoxorubicin results in increased expression of FOS mRNAPMID:16900372
Fosmultiple interactionsISOFos (Mus musculus)6480464CTD[[MT1 protein co-treated with MT2 protein] affects the susceptibility to Doxorubicin] which affects the expression of FOS mRNA; Lovastatin inhibits the reaction [Doxorubicin results in increased expression of FOS mRNA]PMID:21040762 PMID:22712078
Fosmultiple interactionsISOFOS (Homo sapiens)6480464CTDbisphenol A affects the reaction [Doxorubicin affects the expression of FOS mRNA]; bisphenol A inhibits the reaction [Doxorubicin results in decreased expression of FOS mRNA]PMID:26320837 PMID:31470548
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