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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2626
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Fos
Name: Fos proto-oncogene, AP-1 transcription factor subunit
Acc ID: CHEBI:78734
Term: tropan-3alpha-yl 3-hydroxy-2-phenylpropanoate
Definition: A tropane alkaloid that is (1R,5)-8-methyl-8-azabicyclo[3.2.1]octane substituted by a (3-hydroxy-2-phenylpropanoyl)oxy group at position 3.
Chemical ID: MESH:D001285
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Fosincreases expressionEXP 6480464CTDAtropine results in increased expression of FOS proteinPMID:8281324
Fosmultiple interactionsEXP 6480464CTD[asoxime chloride co-treated with Atropine co-treated with Diazepam] affects the reaction [Soman results in increased expression of FOS protein]; Atropine inhibits the reaction [Pilocarpine results in increased expression of FOS mRNA]PMID:21971501 PMID:7968354
Fosmultiple interactionsISOFOS (Homo sapiens)6480464CTDAtropine inhibits the reaction [Paraoxon results in increased expression of FOS mRNA]PMID:21787676
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