FOS (Fos proto-oncogene, AP-1 transcription factor subunit) - Rat Genome Database

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Gene: FOS (Fos proto-oncogene, AP-1 transcription factor subunit) Sus scrofa
Analyze
Symbol: FOS
Name: Fos proto-oncogene, AP-1 transcription factor subunit
RGD ID: 13921310
Description: ENCODES a protein that exhibits DNA binding (ortholog); DNA-binding transcription factor activity (ortholog); double-stranded DNA binding (ortholog); INVOLVED IN cellular response to calcium ion (ortholog); cellular response to epidermal growth factor stimulus (ortholog); cellular response to hormone stimulus (ortholog); PARTICIPATES IN endothelin signaling pathway; fibroblast growth factor signaling pathway; forkhead class A signaling pathway; ASSOCIATED WITH Aberrant Crypt Foci (ortholog); acute myocardial infarction (ortholog); alcohol dependence (ortholog); FOUND IN endoplasmic reticulum (ortholog); nuclear matrix (ortholog); nucleoplasm (ortholog); INTERACTS WITH 1-(5-isoquinolinesulfonyl)-2-methylpiperazine; 5-(2-methylpiperazine-1-sulfonyl)isoquinoline; actinomycin D
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: c-fos; cellular oncogene fos; proto-oncogene c-Fos; proto-oncogene protein c-fos; transcription factor AP-1 subunit c-Fos; v-fos FBJ murine osteosarcoma viral oncogene homolog
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Sscrofa11.1 - Pig Sscrofa11.1 Assembly
Position:
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl798,449,349 - 98,455,554 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1798,449,508 - 98,451,971 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.27104,293,828 - 104,296,291 (+)NCBISscrofa10.2Sscrofa10.2susScr3
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
Aberrant Crypt Foci  (ISO)
acute myocardial infarction  (ISO)
alcohol dependence  (ISO)
alcohol use disorder  (ISO)
alcohol withdrawal syndrome  (ISO)
Alcohol-Related Disorders  (ISO)
Alcoholic Intoxication  (ISO)
amphetamine abuse  (ISO)
amyotrophic lateral sclerosis type 1  (ISO)
Animal Disease Models  (ISO)
anxiety disorder  (ISO)
autosomal dominant polycystic kidney disease  (ISO)
Binge Drinking  (ISO)
Brain Injuries  (ISO)
Breast Neoplasms  (ISO)
cervical squamous cell carcinoma  (ISO)
cocaine abuse  (ISO)
cocaine dependence  (ISO)
Cocaine-Related Disorders  (ISO)
Colonic Neoplasms  (ISO)
colorectal adenocarcinoma  (ISO)
colorectal adenoma  (ISO)
Colorectal Neoplasms  (ISO)
congenital hypothyroidism  (ISO)
congestive heart failure  (ISO)
degenerative disc disease  (ISO)
depressive disorder  (ISO)
endometriosis  (ISO)
epilepsy  (ISO)
Experimental Arthritis  (ISO)
Experimental Liver Cirrhosis  (ISO)
extrahepatic cholestasis  (ISO)
Fetal Growth Retardation  (ISO)
Fibrous Dysplasia of Bone  (ISO)
gastric ulcer  (ISO)
genetic disease  (ISO)
glomerulonephritis  (ISO)
Heat Stroke  (ISO)
Hematuria  (ISO)
hemolytic-uremic syndrome  (ISO)
Hemorrhage  (ISO)
hepatocellular carcinoma  (ISO)
Hyperalgesia  (ISO)
Hyperkinesis  (ISO)
hypertension  (ISO)
Inhalant Abuse  (ISO)
intellectual disability  (ISO)
juvenile rheumatoid arthritis  (ISO)
Kidney Reperfusion Injury  (ISO)
Lung Neoplasms  (ISO)
middle cerebral artery infarction  (ISO)
morphine dependence  (ISO)
morphine withdrawal syndrome  (ISO)
myocardial infarction  (ISO)
Neoplastic Cell Transformation  (ISO)
nervous system disease  (ISO)
nicotine dependence  (ISO)
obesity  (ISO)
ovarian carcinoma  (ISO)
Pick's disease  (ISO)
post-traumatic stress disorder  (ISO)
rectal benign neoplasm  (ISO)
Reperfusion Injury  (ISO)
status epilepticus  (ISO)
Tendon Injuries  (ISO)
Tongue Neoplasms  (ISO)
tongue squamous cell carcinoma  (ISO)
toxic encephalopathy  (ISO)
trigeminal neuralgia  (ISO)
Wernicke encephalopathy  (ISO)
withdrawal disorder  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
cellular response to cadmium ion  (IEA)
cellular response to calcium ion  (IEA,ISO)
cellular response to epidermal growth factor stimulus  (ISO)
cellular response to hormone stimulus  (ISO)
cellular response to hypoxia  (ISO)
cellular response to parathyroid hormone stimulus  (ISO)
cellular response to phorbol 13-acetate 12-myristate  (ISO)
cellular response to prolactin  (ISO)
cellular response to reactive oxygen species  (IEA)
cellular response to transforming growth factor beta stimulus  (ISO)
cellular response to tumor necrosis factor  (ISO)
cellular response to zinc ion starvation  (ISO)
cerebral cortex development  (ISO)
conditioned taste aversion  (ISO)
female pregnancy  (ISO)
mononuclear cell differentiation  (ISO)
myoblast proliferation  (ISO)
nervous system development  (IEA,ISO)
neuron differentiation  (ISO)
obsolete cellular response to extracellular stimulus  (IEA)
osteoclast differentiation  (IEA,ISO)
positive regulation of DNA-templated transcription  (IEA)
positive regulation of miRNA transcription  (IEA)
positive regulation of osteoclast differentiation  (IEA,ISO)
positive regulation of transcription by RNA polymerase II  (IEA,ISO)
regulation of DNA-templated transcription  (IEA,ISO)
regulation of gene expression  (IEA,ISO)
regulation of transcription by RNA polymerase II  (IBA,IEA)
response to activity  (ISO)
response to cAMP  (ISO)
response to corticosterone  (ISO)
response to cytokine  (ISO)
response to ethanol  (ISO)
response to gravity  (ISO)
response to immobilization stress  (ISO)
response to insulin  (ISO)
response to light stimulus  (ISO)
response to lipopolysaccharide  (ISO)
response to mechanical stimulus  (ISO)
response to muscle stretch  (IEA,ISO)
response to organic cyclic compound  (ISO)
response to progesterone  (ISO)
response to steroid hormone  (ISO)
response to toxic substance  (ISO)
response to xenobiotic stimulus  (IEA,ISO)
skeletal muscle cell differentiation  (IEA,ISO)
skeletal muscle cell proliferation  (ISO)
SMAD protein signal transduction  (IEA)
transcription by RNA polymerase II  (IEA,ISO)
transforming growth factor beta receptor signaling pathway  (IEA)

Cellular Component

References
Additional References at PubMed
PMID:8793856   PMID:8898353   PMID:10894939   PMID:14681463   PMID:22301074   PMID:23164930   PMID:30032202  


Genomics

Comparative Map Data
FOS
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl798,449,349 - 98,455,554 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1798,449,508 - 98,451,971 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.27104,293,828 - 104,296,291 (+)NCBISscrofa10.2Sscrofa10.2susScr3
FOS
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381475,278,828 - 75,282,230 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1475,278,826 - 75,282,230 (+)EnsemblGRCh38hg38GRCh38
GRCh371475,745,531 - 75,748,933 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361474,815,284 - 74,818,666 (+)NCBINCBI36Build 36hg18NCBI36
Build 341474,815,283 - 74,818,666NCBI
Celera1455,783,567 - 55,787,023 (+)NCBICelera
Cytogenetic Map14q24.3NCBI
HuRef1455,913,924 - 55,917,380 (+)NCBIHuRef
CHM1_11475,683,266 - 75,686,721 (+)NCBICHM1_1
T2T-CHM13v2.01469,488,228 - 69,491,630 (+)NCBIT2T-CHM13v2.0
Fos
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391285,520,664 - 85,524,048 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1285,520,664 - 85,524,047 (+)EnsemblGRCm39 Ensembl
GRCm381285,473,890 - 85,477,274 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1285,473,890 - 85,477,273 (+)EnsemblGRCm38mm10GRCm38
MGSCv371286,814,851 - 86,818,219 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361286,363,004 - 86,366,372 (+)NCBIMGSCv36mm8
Celera1286,933,225 - 86,936,593 (+)NCBICelera
Cytogenetic Map12D2NCBI
cM Map1239.7NCBI
Fos
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr86110,852,188 - 110,855,054 (+)NCBIGRCr8
mRatBN7.26105,121,170 - 105,124,036 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl6105,121,170 - 105,124,036 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx6105,290,640 - 105,293,508 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.06105,589,531 - 105,592,399 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.06104,959,176 - 104,962,044 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.06109,300,433 - 109,303,299 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl6109,300,433 - 109,303,299 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.06116,249,742 - 116,252,608 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.46109,559,135 - 109,562,001 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.16109,562,609 - 109,566,002 (+)NCBI
Celera6102,942,464 - 102,945,330 (+)NCBICelera
Cytogenetic Map6q31NCBI
Fos
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955523305,728 - 310,728 (-)EnsemblChiLan1.0
ChiLan1.0NW_004955523307,181 - 310,728 (-)NCBIChiLan1.0ChiLan1.0
FOS
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21576,362,508 - 76,366,629 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11475,579,607 - 75,583,133 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01455,832,570 - 55,835,984 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11474,676,316 - 74,679,766 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1474,676,316 - 74,679,766 (+)Ensemblpanpan1.1panPan2
FOS
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1848,330,856 - 48,334,273 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl848,331,026 - 48,333,467 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha848,014,730 - 48,018,137 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0848,558,356 - 48,561,763 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl848,558,343 - 48,561,758 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1848,229,017 - 48,232,423 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0848,250,295 - 48,253,702 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0848,649,028 - 48,652,435 (+)NCBIUU_Cfam_GSD_1.0
Fos
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440864027,680,843 - 27,684,228 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364884,384,705 - 4,388,122 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364884,384,710 - 4,388,118 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
FOS
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12452,497,465 - 52,501,161 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2452,497,521 - 52,501,514 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605340,725,132 - 40,728,594 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Fos
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473426,423,079 - 26,427,732 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473426,424,053 - 26,427,431 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in FOS
72 total Variants

Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system hemolymphoid system musculoskeletal system nervous system renal system reproductive system respiratory system
High
Medium 9 2 1 7 1 1 2
Low 1 4 1 5 1 16 1 2 1
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSSSCT00000002650   ⟹   ENSSSCP00000002583
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl798,449,363 - 98,455,554 (+)Ensembl
RefSeq Acc Id: ENSSSCT00000060279   ⟹   ENSSSCP00000043744
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl798,449,349 - 98,451,971 (+)Ensembl
RefSeq Acc Id: ENSSSCT00000081591   ⟹   ENSSSCP00000070926
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl798,449,365 - 98,452,775 (+)Ensembl
RefSeq Acc Id: ENSSSCT00000084794   ⟹   ENSSSCP00000068601
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl798,449,349 - 98,451,238 (+)Ensembl
RefSeq Acc Id: NM_001123113   ⟹   NP_001116585
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1798,449,508 - 98,451,971 (+)NCBI
Sequence:
Reference Protein Sequences
RefSeq Acc Id: NP_001116585   ⟸   NM_001123113
- UniProtKB: A0A140TAJ8 (UniProtKB/TrEMBL),   A0A4X1TB96 (UniProtKB/TrEMBL),   K4JEE4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSSSCP00000002583   ⟸   ENSSSCT00000002650
RefSeq Acc Id: ENSSSCP00000043744   ⟸   ENSSSCT00000060279
RefSeq Acc Id: ENSSSCP00000068601   ⟸   ENSSSCT00000084794
RefSeq Acc Id: ENSSSCP00000070926   ⟸   ENSSSCT00000081591
Protein Domains
bZIP


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSSCG00000002383 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCG00005034950 UniProtKB/TrEMBL
  ENSSSCG00025046805 UniProtKB/TrEMBL
  ENSSSCG00030035767 UniProtKB/TrEMBL
  ENSSSCG00035021787 UniProtKB/TrEMBL
  ENSSSCG00040051188 UniProtKB/TrEMBL
  ENSSSCG00045036994 UniProtKB/TrEMBL
  ENSSSCG00050062963 UniProtKB/TrEMBL
  ENSSSCG00055002084 UniProtKB/TrEMBL
  ENSSSCG00065061666 UniProtKB/TrEMBL
  ENSSSCG00070007778 UniProtKB/TrEMBL
Ensembl Transcript ENSSSCT00000002650 ENTREZGENE
  ENSSSCT00000002650.4 UniProtKB/TrEMBL
  ENSSSCT00000060279.3 UniProtKB/TrEMBL
  ENSSSCT00000081591.1 UniProtKB/TrEMBL
  ENSSSCT00000084794.1 UniProtKB/TrEMBL
  ENSSSCT00005056104.1 UniProtKB/TrEMBL
  ENSSSCT00025063672.1 UniProtKB/TrEMBL
  ENSSSCT00025063909.1 UniProtKB/TrEMBL
  ENSSSCT00025063968.1 UniProtKB/TrEMBL
  ENSSSCT00030049643.1 UniProtKB/TrEMBL
  ENSSSCT00035028424.1 UniProtKB/TrEMBL
  ENSSSCT00035028426.1 UniProtKB/TrEMBL
  ENSSSCT00035028434.1 UniProtKB/TrEMBL
  ENSSSCT00040069474.1 UniProtKB/TrEMBL
  ENSSSCT00045063757.1 UniProtKB/TrEMBL
  ENSSSCT00045063784.1 UniProtKB/TrEMBL
  ENSSSCT00045063829.1 UniProtKB/TrEMBL
  ENSSSCT00050085766.1 UniProtKB/TrEMBL
  ENSSSCT00055003910.1 UniProtKB/TrEMBL
  ENSSSCT00055003924.1 UniProtKB/TrEMBL
  ENSSSCT00055003954.1 UniProtKB/TrEMBL
  ENSSSCT00065084540.1 UniProtKB/TrEMBL
  ENSSSCT00065084584.1 UniProtKB/TrEMBL
  ENSSSCT00065084593.1 UniProtKB/TrEMBL
  ENSSSCT00070015046.1 UniProtKB/TrEMBL
  ENSSSCT00070015049.1 UniProtKB/TrEMBL
  ENSSSCT00070015056.1 UniProtKB/TrEMBL
Gene3D-CATH 1.20.5.170 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro AP-1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  bZIP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  bZIP_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report ssc:100144486 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene FOS ENTREZGENE
PANTHER PTHR23351 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR23351:SF4 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam bZIP_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PRINTS LEUZIPPRFOS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE BZIP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  BZIP_BASIC UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART BRLZ UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF57959 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A140TAJ8 ENTREZGENE, UniProtKB/TrEMBL
  A0A287AIM1_PIG UniProtKB/TrEMBL
  A0A4X1TAK4_PIG UniProtKB/TrEMBL
  A0A4X1TAR5_PIG UniProtKB/TrEMBL
  A0A4X1TB96 ENTREZGENE, UniProtKB/TrEMBL
  A0A5G2RHQ3_PIG UniProtKB/TrEMBL
  A0A8D0K056_PIG UniProtKB/TrEMBL
  FOS_PIG UniProtKB/Swiss-Prot
  K4JEE4 ENTREZGENE, UniProtKB/TrEMBL
  O97930 ENTREZGENE
UniProt Secondary A0A5G2QUH7 UniProtKB/TrEMBL