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GENE - TERM ANNOTATION REPORT

RGD ID: 13921310
Species: Sus scrofa
RGD Object: Gene
Symbol: FOS
Name: Fos proto-oncogene, AP-1 transcription factor subunit
Acc ID: GO:0035976
Term: transcription factor AP-1 complex
Definition: A heterodimeric transcription factor complex composed of proteins from the c-Fos, c-Jun, activating transcription factor (ATF) or JDP families. The subunits contain a basic leucine zipper (bZIP) domain that is essential for dimerization and DNA binding. Jun-Fos heterodimers bind preferentially to a heptamer consensus sequence (TPA responsive element (TRE)), whereas Jun-ATF dimers bind the cyclic AMP responsive element (CRE) to regulate transcription of target genes.
Definition Source(s): GOC:bf, GOC:BHF, GOC:rl, PMID:20060892, PMID:9069263, Wikipedia:AP-1_transcription_factor
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
FOSlocated_inISOFOS (Homo sapiens)9068941ComplexPortal PMID:7816143 PMID:9510247

PMID:7816143 PMID:9510247
FOSpart_ofIEAUniProtKB:P01100 or UniProtKB:P01101 or ensembl:ENSMUSP00000021674 or ensembl:ENSP00000306245150520179Ensembl GO_REF:0000107
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