RGD Reference Report - Antidepressant effect of electroacupuncture on modulating the expression of c-Fos/AP-1 through the JNK signaling pathway. - Rat Genome Database

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Antidepressant effect of electroacupuncture on modulating the expression of c-Fos/AP-1 through the JNK signaling pathway.

Authors: Li, Xiang  Qi, Si-Min  Wang, Yu  Jiang, Hui-Wu  Li, Ya-Huan  Zhao, Bing-Cong  Zhang, Tao  Sun, Yang  Gao, Xing-Zhou  Quan, Song-Xiao  Liu, Peng-Fei  Li, Wen-Shan  Wu, Ji-Hong  Bao, Tu-Ya  Jiang, Hui-Li 
Citation: Li X, etal., Anat Rec (Hoboken). 2021 Nov;304(11):2480-2493. doi: 10.1002/ar.24740. Epub 2021 Aug 25.
RGD ID: 405650599
Pubmed: PMID:34431619   (View Abstract at PubMed)
DOI: DOI:10.1002/ar.24740   (Journal Full-text)

The effectiveness and safety of electroacupuncture (EA) for depression have been identified by abundant clinical trials and experimental findings. The c-Jun-NH(2)-terminal kinase (JNK) signaling pathway is considered to be involved in the antidepressant mechanism of EA. However, the antidepressant effect of EA via modulating the expression of c-Fos/activator protein-1 (AP-1) under the condition of JNK inhibition remains unexplored. In this study, we investigated the antidepressant effect and possible mechanism of EA in regulating the expression of c-Fos/AP-1 under the condition of JNK inhibition by SP600125 in rats exposed to chronic unpredictable mild stress (CUMS). The depression-like behaviors were evaluated by the body weight, sucrose preference test (SPT), and open field test (OFT). The expression levels of c-Jun in the hypothalamus, c-Fos in the pituitary gland, and c-Fos and AP-1 in the serum of CUMS induced rat model of depression were detected by ELISA. The results indicated that treatment with EA and fluoxetine can reverse the CUMS-induced depression-like behaviors in rats and can up-regulate the expression levels of c-Jun in the hypothalamus, c-Fos in the pituitary gland, and c-Fos and AP-1 in the serum. Of note, the data demonstrated that SP600125, the inhibitor of JNK signaling pathway, can exert synergistic effect with EA in regulating CUMS-induced abnormal activation of the JNK signaling pathway. The antidepressant effect of EA might be mediated by modulating the expression of c-Fos/AP-1.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
depressive disorder treatmentISOFos (Rattus norvegicus)405650599; 405650599 RGD 
depressive disorder treatmentIEP 405650599 RGD 

Objects Annotated

Genes (Rattus norvegicus)
Fos  (Fos proto-oncogene, AP-1 transcription factor subunit)

Genes (Mus musculus)
Fos  (FBJ osteosarcoma oncogene)

Genes (Homo sapiens)
FOS  (Fos proto-oncogene, AP-1 transcription factor subunit)


Additional Information