RGD Reference Report - Distinctive features of Egr transcription factor regulation and DNA binding activity in CA1 of the hippocampus in synaptic plasticity and consolidation and reconsolidation of fear memory.

General

Distinctive features of Egr transcription factor regulation and DNA binding activity in CA1 of the hippocampus in synaptic plasticity and consolidation and reconsolidation of fear memory.
Authors:	Cheval, H Chagneau, C Levasseur, G Veyrac, A Faucon-Biguet, N Laroche, S Davis, S
Citation:	Cheval H, etal., Hippocampus. 2011 Mar 18. doi: 10.1002/hipo.20926.
RGD ID:	5131650
Pubmed:	PMID:21425206 (View Abstract at PubMed)
DOI:	DOI:10.1002/hipo.20926 (Journal Full-text)
Activity-dependent regulation of Egr1/Zif268, a transcription factor (TF) of the Egr family, is essential for stabilization of dentate gyrus synaptic plasticity and consolidation and reconsolidation of several forms of memory. The gene can be rapidly induced in selective brain circuits after certain types of learning or after recall. Here, we focused on area CA1 and examined regulation of Egr1, Egr2, and Egr3 mRNA and protein, and their DNA binding activity to the Egr response element (ERE) at different times after LTP in vivo and after learning and recall of a fear memory. We found LTP in CA1 leads to rapid induction of the three Egrs, however only Egr1 protein was overexpressed without a co-ordinated change in binding activity, indicating a fundamental difference between CA1 and dentate gyrus LTP. Our investigations in fear memory reveal that both learning and retrieval lead to an increase in binding of constitutively expressed Egr1 and Egr3 to the ERE, but not Egr2. Memory recall was also associated with increased Egr1 protein translation. The nature and temporal dynamics of these changes and tests for interactions between TFs suggest that in addition to ERE-mediated transcription, Egr1 in CA1 may interact with the TF c-Fos to regulate genes via other DNA response elements. (c) 2011 Wiley-Liss, Inc.

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Biological Process

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Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
long-term synaptic potentiation		IEP		5131650		RGD

Molecular Function

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Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
transcription factor binding		IPI	Fos (Rattus norvegicus)	5131650		RGD
transcription factor binding		IPI	Egr1 (Rattus norvegicus)	5131650		RGD

Objects Annotated

Genes (Rattus norvegicus)

Egr1 (early growth response 1)

Fos (Fos proto-oncogene, AP-1 transcription factor subunit)

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Distinctive features of Egr transcription factor regulation and DNA binding activity in CA1 of the hippocampus in synaptic plasticity and consolidation and reconsolidation of fear memory.