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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2626
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Fos
Name: Fos proto-oncogene, AP-1 transcription factor subunit
Acc ID: CHEBI:64090
Term: tert-butyl hydroperoxide
Definition: An alkyl hydroperoxide in which the alkyl group is tert-butyl. It is widely used in a variety of oxidation processes.
Chemical ID: MESH:D020122
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Fosdecreases expressionISOFOS (Homo sapiens)6480464CTDtert-Butylhydroperoxide results in decreased expression of FOS mRNAPMID:12419474
Fosincreases expressionISOFos (Mus musculus)6480464CTDtert-Butylhydroperoxide results in increased expression of FOS mRNAPMID:15105052
Fosincreases expressionISOFOS (Homo sapiens)6480464CTDtert-Butylhydroperoxide results in increased expression of FOS mRNAPMID:27509014
Fosincreases methylationISOFOS (Homo sapiens)6480464CTDtert-Butylhydroperoxide results in increased methylation of FOS genePMID:27509014
Fosmultiple interactionsISOFos (Mus musculus)6480464CTDCAT protein inhibits the reaction [tert-Butylhydroperoxide results in increased expression of FOS mRNA]; Glutathione inhibits the reaction [tert-Butylhydroperoxide results in increased expression of FOS mRNA]; Thiourea inhibits the reaction [tert-Butylhydroperoxide results in increased expression of FOS mRNA]PMID:15105052
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