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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2626
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Fos
Name: Fos proto-oncogene, AP-1 transcription factor subunit
Acc ID: CHEBI:4027
Term: cyclophosphamide
Definition: A phosphorodiamide that is 1,3,2-oxazaphosphinan-2-amine 2-oxide substituted by two 2-chloroethyl groups at the amino nitrogen atom.
Chemical ID: MESH:D003520
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Fosincreases expressionEXP 6480464CTDCyclophosphamide results in increased expression of FOS proteinPMID:10749792 PMID:15099680 PMID:15217452 PMID:17240043 PMID:7498375 PMID:8801120 PMID:8808730 PMID:9776515
Fosmultiple interactionsEXP 6480464CTDalfuzosin inhibits the reaction [Cyclophosphamide results in increased expression of FOS protein]; Capsaicin inhibits the reaction [Cyclophosphamide results in increased expression of FOS protein]; resiniferatoxin inhibits the reaction [Cyclophosphamide results in increased expression of FOS protein]PMID:10749792 PMID:15217452 PMID:17240043
Fosincreases expressionISOFos (Mus musculus)6480464CTDCyclophosphamide results in increased expression of FOS mRNAPMID:18093676
Fosmultiple interactionsISOFos (Mus musculus)6480464CTDCapsaicin inhibits the reaction [Cyclophosphamide results in increased expression of FOS mRNA]PMID:18093676
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