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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2626
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Fos
Name: Fos proto-oncogene, AP-1 transcription factor subunit
Acc ID: CHEBI:17243
Term: mono(2-ethylhexyl) phthalate
Definition: The mono(2-ethylhexyl) ester of benzene-1,2-dicarboxylic acid.
Chemical ID: MESH:C016599
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Fosincreases expressionEXP 6480464CTDmono-(2-ethylhexyl)phthalate results in increased expression of FOS mRNAPMID:16809437
Fosincreases expressionISOFos (Mus musculus)6480464CTDmono-(2-ethylhexyl)phthalate results in increased expression of FOS mRNAPMID:8764118
Fosmultiple interactionsISOFos (Mus musculus)6480464CTDmono-(2-ethylhexyl)phthalate inhibits the reaction [GDNF protein results in increased expression of FOS mRNA]; mono-(2-ethylhexyl)phthalate inhibits the reaction [GDNF protein results in increased expression of FOS protein]PMID:22564763
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