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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2626 Species: Rattus norvegicus RGD Object: Gene Symbol: Fos Name: FBJ osteosarcoma oncogene

Acc ID: CHEBI:28694 Term: copper atom Definition: A copper group element atom that has formula Cu. CasRN: 7440-50-8 Chemical ID: MESH:D003300

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
multiple interactions	ISO	RGD:735729	6480464	CTD	Copper promotes the reaction [pyrrolidine dithiocarbamic acid promotes the reaction [[JUN protein binds to FOS protein] which results in increased expression of and results in increased activity of CP protein]]	PMID:17032174
multiple interactions	ISO	RGD:735729	6480464	CTD	[NSC 689534 binds to Copper] which results in increased expression of FOS mRNA	PMID:20971185
increases expression	EXP		6480464	CTD	Copper results in increased expression of FOS mRNA	PMID:22465980
decreases expression	ISO	RGD:735729	6480464	CTD	Copper results in decreased expression of FOS mRNA	PMID:16391388 PMID:16246896
decreases expression	ISO	RGD:735729	6480464	CTD	Copper results in decreased expression of FOS mRNA	PMID:16246896 PMID:16391388