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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2626
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Fos
Name: Fos proto-oncogene, AP-1 transcription factor subunit
Acc ID: CHEBI:16236
Term: ethanol
Definition: A primary alcohol that is ethane in which one of the hydrogens is substituted by a hydroxy group.
Chemical ID: MESH:D000431
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Fosdecreases expressionEXP 6480464CTDEthanol results in decreased expression of FOS mRNAPMID:34547370
Fosincreases expressionEXP 6480464CTDEthanol results in increased expression of FOS mRNA; Ethanol results in increased expression of FOS proteinPMID:11860963 PMID:12065697 PMID:12217933 PMID:14741756 PMID:15234257 PMID:21999510
Fosmultiple interactionsEXP 6480464CTD[Chlorpyrifos results in decreased expression of FOS protein] which affects the susceptibility to Ethanol; Cocaine promotes the reaction [Ethanol results in increased expression of FOS protein]; Ethanol promotes the reaction [Cocaine results in increased expression of FOS protein]PMID:14741756 PMID:17190973
Fosaffects expressionISOFos (Mus musculus)6480464CTDEthanol affects the expression of FOS mRNA; Ethanol deficiency affects the expression of FOS proteinPMID:27126842 PMID:30319688
Fosincreases expressionISOFos (Mus musculus)6480464CTDEthanol results in increased expression of FOS mRNAPMID:20067348
Fosmultiple interactionsISOFOS (Homo sapiens)6480464CTD[[Gasoline co-treated with Ethanol] results in increased abundance of [Particulate Matter co-treated with Polycyclic Aromatic Hydrocarbons]] which results in increased expression of FOS mRNAPMID:29432896
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