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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2626
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Fos
Name: Fos proto-oncogene, AP-1 transcription factor subunit
Acc ID: CHEBI:27899
Term: cisplatin
Definition: A diamminedichloroplatinum compound in which the two ammine ligands and two chloro ligands are oriented in a cis planar configuration around the central platinum ion. An anticancer drug that interacts with, and forms cross-links between, DNA and proteins, it is used as a neoplasm inhibitor to treat solid tumours, primarily of the testis and ovary. Commonly but incorrectly described as an alkylating agent due to its mechanism of action (but it lacks alkyl groups).
Chemical ID: MESH:D002945
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Fosdecreases expressionEXP 6480464CTDCisplatin results in decreased expression of FOS mRNAPMID:22023808
Fosincreases expressionEXP 6480464CTDCisplatin results in increased expression of FOS mRNA; Cisplatin results in increased expression of FOS proteinPMID:18172885 PMID:19383537 PMID:19710391
Fosmultiple interactionsEXP 6480464CTDdecitabine inhibits the reaction [FOS protein results in decreased susceptibility to Cisplatin]PMID:18314485
Fosaffects expressionISOFos (Mus musculus)6480464CTDCisplatin affects the expression of FOS proteinPMID:37769865
Fosaffects response to substanceISOFOS (Homo sapiens)6480464CTDFOS protein affects the susceptibility to CisplatinPMID:16217747
Fosincreases expressionISOFos (Mus musculus)6480464CTDCisplatin results in increased expression of FOS mRNAPMID:19428948 PMID:19833167 PMID:21151649 PMID:23384965
Fosincreases expressionISOFOS (Homo sapiens)6480464CTDCisplatin results in increased expression of FOS mRNA; Cisplatin results in increased expression of FOS proteinPMID:16082193 PMID:19383537 PMID:33545341
Fosmultiple interactionsISOFos (Mus musculus)6480464CTD1,3-dimethylthiourea inhibits the reaction [Cisplatin results in increased expression of FOS mRNA]; Cisplatin inhibits the reaction [[9,10-Dimethyl-1,2-benzanthracene co-treated with Croton Oil] results in increased expression of FOS mRNA]; Cisplatin promotes the reaction [NPPC protein inhibits the reaction [[9,10-Dimethyl-1,2-benzanthracene co-treated with Croton Oil] results in increased expression of FOS mRNA]]; MIR155 gene mutant form promotes the reaction [Cisplatin results in increased expression of FOS mRNA]; MIR155 gene mutant form promotes the reaction [Cisplatin results in increased expression of FOS protein]; NPPC protein promotes the reaction [Cisplatin inhibits the reaction [[9,10-Dimethyl-1,2-benzanthracene co-treated with Croton Oil] results in increased expression of FOS mRNA]]PMID:23384965 PMID:25015656 PMID:37352108
Fosmultiple interactionsISOFOS (Homo sapiens)6480464CTD[Cisplatin co-treated with Quercetin] results in increased expression of FOS mRNA; Cisplatin promotes the reaction [Quercetin results in increased expression of FOS protein]; Quercetin promotes the reaction [Cisplatin results in increased expression of FOS protein]PMID:16082193 PMID:27514524
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