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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2626 Species: Rattus norvegicus RGD Object: Gene Symbol: Fos Name: FBJ osteosarcoma oncogene

Acc ID: CHEBI:2663 Term: amiodarone Definition: An organoiodine compound that has formula C25H29I2NO3. CasRN: 1951-25-3 Chemical ID: MESH:D000638

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
increases expression	ISO	RGD:735729	6480464	CTD	Amiodarone results in increased expression of FOS mRNA	PMID:19774075
multiple interactions	ISO	RGD:735729	6480464	CTD	[FOS protein co-treated with JUN protein] promotes the reaction [Amiodarone results in increased expression of AGT mRNA]	PMID:17214612