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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2626 Species: Rattus norvegicus RGD Object: Gene Symbol: Fos Name: FBJ osteosarcoma oncogene

Acc ID: CHEBI:18295 Term: histamine Definition: A 1H-imidazol-4-yl group substituted at position C-4 by a 2-aminoethyl group. CasRN: 51-45-6 Chemical ID: MESH:D006632

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
multiple interactions	ISO	RGD:735729	6480464	CTD	[Histamine binds to and results in increased activity of HRH2 protein] which results in increased expression of FOS mRNA Famotidine inhibits the reaction [[Histamine binds to and results in increased activity of HRH2 protein] which results in increased expression of FOS mRNA]	PMID:9187264