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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2626
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Fos
Name: Fos proto-oncogene, AP-1 transcription factor subunit
Acc ID: CHEBI:17688
Term: (S)-nicotine
Definition: A 3-(1-methylpyrrolidin-2-yl)pyridine in which the chiral centre has S-configuration. The naturally occurring and most active enantiomer of nicotine, isolated from Nicotiana tabacum.
Chemical ID: MESH:D009538
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Fosdecreases expressionEXP 6480464CTDNicotine results in decreased expression of FOS mRNAPMID:16690037
Fosincreases expressionEXP 6480464CTDNicotine results in increased expression of FOS mRNA; Nicotine results in increased expression of FOS proteinPMID:16251992 PMID:16690037 PMID:17287824 PMID:20426880
Fosmultiple interactionsEXP 6480464CTDAcetaldehyde promotes the reaction [Nicotine results in increased expression of FOS mRNA]; Saponins inhibits the reaction [Nicotine results in increased expression of FOS protein]PMID:16251992 PMID:17287824
Fosaffects expressionISOFos (Mus musculus)6480464CTDNicotine deficiency affects the expression of FOS proteinPMID:27126842
Fosincreases expressionISOFos (Mus musculus)6480464CTDNicotine results in increased expression of FOS mRNA; Nicotine results in increased expression of FOS proteinPMID:15857624 PMID:17456735
Fosincreases expressionISOFOS (Homo sapiens)6480464CTDNicotine results in increased expression of FOS; Nicotine results in increased expression of FOS mRNA; Nicotine results in increased expression of FOS proteinPMID:11425648 PMID:17003101 PMID:17151781
Fosincreases phosphorylationISOFOS (Homo sapiens)6480464CTDNicotine results in increased phosphorylation of FOS proteinPMID:34171359 PMID:34890707
Fosmultiple interactionsISOFOS (Homo sapiens)6480464CTD[U 0126 results in decreased activity of [MAPK1 protein co-treated with MAPK3 protein]] inhibits the reaction [Nicotine results in increased expression of FOS protein]; SB 203580 inhibits the reaction [Nicotine results in increased phosphorylation of FOS protein]; Tubocurarine inhibits the reaction [Nicotine results in increased expression of FOS]PMID:11425648 PMID:17003101 PMID:34171359
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