Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models   new Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources

GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2626
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Fos
Name: Fos proto-oncogene, AP-1 transcription factor subunit
Acc ID: CHEBI:30621
Term: diarsenic trioxide
Definition: An arsenic oxide in which arsenic and oxygen atoms are present in the ratio 2:3.
Chemical ID: MESH:C006632
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Fosdecreases expressionEXP 6480464CTDArsenic Trioxide results in decreased expression of FOS mRNAPMID:29223816
Fosaffects expressionISOFOS (Homo sapiens)6480464CTDArsenic Trioxide affects the expression of FOS mRNA; Arsenic Trioxide affects the expression of FOS proteinPMID:12749819 PMID:19444595
Fosdecreases activityISOFos (Mus musculus)6480464CTDArsenic Trioxide results in decreased activity of FOS proteinPMID:29049341
Fosdecreases expressionISOFos (Mus musculus)6480464CTDArsenic Trioxide results in decreased expression of FOS mRNAPMID:19410645 PMID:35676786
Fosdecreases expressionISOFOS (Homo sapiens)6480464CTDArsenic Trioxide results in decreased expression of FOS mRNAPMID:20458559
Fosincreases expressionISOFOS (Homo sapiens)6480464CTDArsenic Trioxide results in increased expression of FOS mRNA; Arsenic Trioxide results in increased expression of FOS proteinPMID:11678611 PMID:14682389 PMID:18822310 PMID:23883479 PMID:24956101 PMID:25258189 PMID:25574600 PMID:25791921 PMID:27829220 PMID:29633893
Fosmultiple interactionsISOFOS (Homo sapiens)6480464CTD[Arsenic Trioxide results in increased phosphorylation of and results in increased activity of FOS protein] promotes the reaction [FOS protein binds to CDKN1A promoter]; [Arsenic Trioxide results in increased phosphorylation of and results in increased activity of FOS protein] promotes the reaction [FOS protein results in increased expression of CDKN1A mRNA]; Arsenic Trioxide promotes the reaction [[FOS protein binds to JUN promoter] which binds to CDKN1A promoter]; Arsenic Trioxide promotes the reaction [[FOS protein binds to JUN protein] which results in increased expression of CDKN1A mRNA]; Arsenic Trioxide promotes the reaction [FOS protein binds to CDKN1A promoter]; Arsenic Trioxide promotes the reaction [MAPK1 protein promotes the reaction [FOS protein binds to CDKN1A promoter]]; Arsenic Trioxide promotes the reaction [MAPK3 protein promotes the reaction [FOS protein binds to CDKN1A promoter]]; Arsenic Trioxide promotes the reaction [nilotinib results in increased expression of FOS mRNA]; Arsenic Trioxide promotes the reaction [nilotinib results in increased expression of FOS protein]; Arsenic Trioxide results in increased expression of and results in increased phosphorylation of FOS protein; Atrazine promotes the reaction [Arsenic Trioxide results in increased expression of FOS mRNA]; U 0126 inhibits the reaction [Arsenic Trioxide results in increased expression of and results in increased phosphorylation of FOS protein]; U 0126 inhibits the reaction [Arsenic Trioxide results in increased expression of FOS mRNA]; U 0126 inhibits the reaction [Arsenic Trioxide results in increased expression of FOS protein]PMID:11678611 PMID:18822310 PMID:23883479 PMID:25791921
Go Back to source page   Continue to Ontology report