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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2626 Species: Rattus norvegicus RGD Object: Gene Symbol: Fos Name: FBJ osteosarcoma oncogene

Acc ID: CHEBI:10110 Term: zidovudine Definition: A pyrimidine 2',3'-dideoxyribonucleoside compound having a 3'-azido substituent and thymine as the nucleobase. CasRN: 30516-87-1 Chemical ID: MESH:D015215

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
multiple interactions	ISO	RGD:10596	6480464	CTD	EPO protein inhibits the reaction [Zidovudine results in decreased expression of FOS mRNA] IL3 protein promotes the reaction [EPO protein inhibits the reaction [Zidovudine results in decreased expression of FOS mRNA]]	PMID:7646543
decreases expression	ISO	RGD:10596	6480464	CTD	Zidovudine results in decreased expression of FOS mRNA	PMID:7646543